Results 81 to 90 of about 647,754 (283)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Bianchi-V string cosmological model and late time acceleration

, 2012
In the present work we have searched the existence of the late time acceleration of the universe with string fluid as source of matter in Bianchi V space-time.
Anil Kumar Yadav, Bali, Chakraborty, Kibble, Pogosian, Riess, Yadav, Zeldovich   +7 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Building the First Galaxies—Chapter 2. Starbursts Dominate the Star Formation Histories of 6 < z < 12 Galaxies

The Astrophysical Journal
We use SEDz* —a code designed to chart the star formation histories (SFHs) of 6 < z < 12 galaxies—to analyze the spectral energy distributions (SEDs) of 894 galaxies with deep JWST/NIRCam imaging by JADES in the GOODS-S field.
Alan Dressler, Marcia Rieke, Daniel Eisenstein, Daniel P. Stark, Chris Burns, Rachana Bhatawdekar, Nina Bonaventura, Kristan Boyett, Andrew J. Bunker, Stefano Carniani, Stephane Charlot, Ryan Hausen, Karl Misselt, Sandro Tacchella, Christopher Willmer   +14 more
doaj   +1 more source

Detection of early-universe gravitational-wave signatures and fundamental physics. [PDF]

Gen Relativ Gravit, 2022
Caldwell R, Cui Y, Guo HK, Mandic V, Mariotti A, No JM, Ramsey-Musolf MJ, Sakellariadou M, Sinha K, Wang LT, White G, Zhao Y, An H, Bian L, Caprini C, Clesse S, Cline JM, Cusin G, Fornal B, Jinno R, Laurent B, Levi N, Lyu KF, Martinez M, Miller AL, Redigolo D, Scarlata C, Sevrin A, Haghi BSE, Shu J, Siemens X, Steer DA, Sundrum R, Tamarit C, Weir DJ, Xie KP, Yang FW, Zhou S.   +37 more
europepmc   +1 more source