Results 111 to 120 of about 3,452,639 (298)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Solar wind origin of terrestrial water
, 2011 The origin of the Earth water reserves during the evolution of the planet is one of the big miracles in geophysics. Common explanations are storage of water in the Earth mantle at a time when the crust had not yet formed and depositing of water by comets
Fraenz, Markus, Merkl, Hans
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Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Eski Türklerde Şamanizm ve Günümüze Yansımaları
AhbarEski Türklerin manevi dünyası, günümüzde bile hala büyük bir merak ve ilgi konusudur. Bu ilginin odağında ise şamanizm yer alır. Şamanizm, sadece bir inanç sistemi olmanın ötesinde, eski Türk toplumlarının dünya görüşünü, yaşam biçimlerini ve evrenle ...
Melisa Çamurcuoğlu Tosun
doaj
Marco Polo: A near Earth object sample return mission [PDF]
, 2008 From Introduction: MARCO POLO is a joint European-Japanese sample return mission to a Near-Earth Object. In late 2007 this mission was selected by ESA, in the framework of COSMIC VISION 2015-2025, for an assessment scheduled to last until mid 2009.
Barucci, M. A. +17 more
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
, 1971 The organization, operations, functions, and objectives of NASA are outlined. Data include manned space flights, satellite weather observations, orbiting radio relays, and new views of the earth and beyond the earth as observed by satellites.
core +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Earth Care and Recovery in Kerri ní Dochartaigh’s Thin Places (2021) [PDF]
Estudios IrlandesesThin Places (2021) is a piece of work which defies categorization. It is partly a memoir filled with traumatic personal events, partly a reflection on loss in all its manifest forms (physical, familial, linguistic, environmental), and partly an uplifting
Fiona McCann
doaj
Optimisation of Low-Thrust and Hybrid Earth-Moon Transfers [PDF]
, 2016 This paper presents an optimization procedure to generate fast and low-∆v Earth-Moon transfer trajectories, by exploiting the multi-body dynamics of the Sun-Earth-Moon system.
Ceriotti, Matteo +3 more
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