Results 81 to 90 of about 3,452,639 (298)
, 2009 In a reference frame fixed to the solar system's center of mass, a satellite's energy will change as it is deflected by a planet. But a number of satellites flying by Earth have also experienced energy changes in the Earth-centered frame -- and that's a ...
Anderson, John D., Nieto, Michael Martin
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The road toward a general relativistic metric inside the Earth and its effect on neutrino travel from CERN to GRAN-SASSO Laboratory [PDF]
, 2012 In a first attempt to describe the effect on neutrino travel inside the Earth caused by general relativity in the case of a dense Earth, we have neglected the Earth's rotation, the Earth's ellipticity and also the surface terrain variation, nevertheless ...
Besida, Olivier
core +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Measurement of the earthshine polarization in the B, V, R, and I band as function of phase
, 2013 The characterization of the polarimetric properties of the planet Earth is important for the interpretation of expected observations and the planning of future instruments.
Bazzon, Andreas +2 more
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Correction to the references Nurhasan OY et al (2006) and Tseng KH et al (2020)
Earth, Planets and Space, 2021 Earth, Planets and Space
doaj +1 more source
The role of dynamics on the habitability of an Earth-like planet
, 2014 From the numerous detected planets outside the Solar system, no terrestrial planet comparable to our Earth has been discovered so far. The search for an Exo-Earth is certainly a big challenge which may require the detections of planetary systems ...
Pilat-Lohinger, E.
core +1 more source