Results 81 to 90 of about 1,162,220 (312)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Earth systems and Earth science informatics [PDF]
Earth Science Informatics, 2008 Earth scientists collect, store, manage, process, and organize data about the different components of the Earth system, and about natural and simulated processes. The transition from data to information is achieved through computation, visualization, and other processes that make the data more meaningful to the scientists.
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Een inventariserend veldonderzoek door middel van boringen (IVO-O), verkennende en karterende fase
, 2017 Een inventariserend veldonderzoek door middel van boringen (IVO-O), verkennende en karterende ...
EARTH Integrated Archaeology B.V.
core +1 more source
Een archeologisch bureauonderzoek (BO)
, 2021 In maart 2021 heeft EARTH Integrated Archaeology een archeologisch bureauonderzoek (BO) uitgevoerd binnen een plangebied aan de Karolingersweg te Wijk bij Duurstede. Oorzaak zijn geplande grondverstorende werkzaamheden in het gebied.
Zijverden, Dr. W. van (EARTH Integrated Archaeology) +1 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Simulator Posisi Matahari dan Bulan Berbasis Web dengan WebGL
Jurnal Nasional Teknik Elektro, 2014 Moon as a satellite of the earth has an important role for the life of the earth. Apart from being a source of illumination, moon also has an effect on the earth both on land and at sea.
Kamshory, Syafii
doaj
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source