Results 81 to 90 of about 1,446,705 (302)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Notas sobre luta, Encantados e o povo Pataxó Hãhãhãi

Argumentos
This article presents situations and reports of the relationships between the Pataxó Hãhãhãi People in the Caramuru-Paraguassu Indigenous Land, located between the municipalities of Pau Brasil, Itaju do Colônia and Camacã, in southern
Jurema Machado de Andrade Souza
doaj   +1 more source

První koncepce kulovité Země v antické kosmologii

Filosofický časopis, 2022
Although it is not until we get to Aristotle that we can be absolutely certain of finding a spherical Earth in ancient cosmology, Diogenes Laertios considers it to have been first conceived by Pythagoras and Parmenides.
Kočandrle, Radim
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Een inventariserend veldonderzoek door middel van boringen (IVO-O), verkennende fase

, 2017
Een inventariserend veldonderzoek door middel van boringen (IVO-O), verkennende ...
EARTH Integrated Archaeology B.V.
core   +1 more source

EARTH Integrated Archaeology Rapporten 144

, 2022
EARTH Integrated Archaeology B.V. heeft in maart-april 2020 een Inventariserend Veldonderzoek (IVO) karterende fase door middel van boringen uitgevoerd in plangebied Goudplevierweg- Kathedralenpad in Oosterwold, gemeente Almere.
Devriendt, Dr. I., Rumping, BSc S (EARTH Integrated Archaeology), Moor, Dr. J.J.W. de (EARTH Integrated Archaeology)   +2 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Een archeologisch en cultuurhistorisch bureauonderzoek (BO)

, 2022
In juni-november 2021 heeft EARTH Integrated Archaeology een archeologisch en cultuurhistorisch bureauonderzoek uitgevoerd voor drieplangebieden in de gemeenten Kaag en Braassem en Alphen aan den Rijn.
Vanderhoeven, Drs. T. (EARTH Integrated Archaeology), Jobse, MSc M. (EARTH Integrated Archaeology), Grothe, MSc K. (EARTH Integrated ArchaeologyEARTH Integrated Archaeology), Rumping, MSc S. (EARTH Integrated Archaeology), Bazuin-Zwart, MSc T. (EARTH Integrated Archaeology)   +4 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source