Results 61 to 70 of about 301,374 (236)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Interplanetary Mission Performance Assessment of a TANDEM Electric Thruster-Based Spacecraft

Applied Sciences
The aim of this paper is to analyze the transfer performance of a spacecraft equipped with a TANDEM electric propulsion system in a classical interplanetary mission scenario targeting Mars, Venus, or a near-Earth asteroid. The TANDEM concept is a coaxial,
Alessandro A. Quarta
doaj   +1 more source

Plants as Aristotelian Substances [PDF]

, 1991
published or submitted for ...
Sprague, Rosemary Kent
core  

On the reliability of the so far performed tests for measuring the Lense-Thirring effect with the LAGEOS satellites

, 2005
In this paper we will show in detail that the performed attempts aimed at the detection of the general relativistic Lense-Thirring effect in the gravitational field of the Earth with the existing LAGEOS satellites are often presented in an optimistic and
Allison, Casotto, Cheng, Ciufolini, Ciufolini, Ciufolini, Ciufolini, Ciufolini, Ciufolini, Ciufolini, Ciufolini, Eanes, Everitt, Gruber, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Iorio, Kaula, Lense, Lucchesi, Lucchesi, Lucchesi, Lucchesi, Lucchesi, Lucchesi, Lämmerzahl, Lämmerzahl, Mashhoon, Nordtvedt, Pavlis, Pavlis, Reigber, Reigber, Reigber, Reigber, Ries, Ruggiero, Schiff, Schäfer, Tapley, Tapley, Vespe, Will   +53 more
core   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Nature, origin and significance of a clayey cave deposit: Relationship between karst and Oligocene/Miocene tephra (NW Dinarides)

The Depositional Record
A limestone cave filled with montmorillonite clay was found in a hill above the karst plateau on the north‐eastern edge of the Adriatic Sea. The cave fill shows no correlation with sediments found in the surrounding caves or other known caves of the ...
Nadja Zupan Hajna, Pavel Bosák, Andrej Mihevc, Michał Banaś, Jiří Filip, Lukáš Krmíček, Lenka Lisá, Šárka Matoušková, Jan Rohovec, Roman Skála, Jiří Sláma, Martin Šťastný, Jaromír Ulrych   +12 more
doaj   +1 more source

Investigation of Lateral Stress Relief on theStability of PHI = 0 DEG Slopes Using Laboratory, Fracture Mechanics, and Finite Element Method Approaches [PDF]

, 2011
Total stress analyses of purely cohesive cut slopes utilize the undrained shear strength for slope stability analyses. These slopes can have an in-situ lateral earth pressure that is greater than the vertical pressure.
Kutschke, Walter
core  

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source