Results 141 to 150 of about 158,991 (313)
Capacity Building in Earth Observation: from Outcomes to Impact and Sustainability : abstract + powerpoint [PDF]
, 2018 Spatial solutions play an increasingly important role in meeting many of humankind’s complex challenges, such as climate change, population growth, and related claims for sufficient and secure food, water, energy, health, land and housing provision ...
Nancy, Searby +4 more
core
Assessment of C-Band Polarimetric Radar for the Detection of Diesel Fuel in Newly Formed Sea Ice
Remote SensingThere is a heightened risk of an oil spill occurring in the Arctic, as climate change driven sea ice loss permits an increase in Arctic marine transportation.
Leah Hicks +6 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
GlobalBuildingMap — Unveiling the mystery of global buildings
Scientific DataUnderstanding how buildings are distributed globally is crucial to revealing the human footprint on our home planet. This built environment affects local climate, land surface albedo, resource distribution, and many other key factors that influence well ...
Xiao Xiang Zhu +6 more
doaj +1 more source
UnDER: Unsupervised Dense Point Cloud Extraction Routine for UAV Imagery Using Deep Learning
Remote SensingExtraction of dense 3D geographic information from ultra-high-resolution unmanned aerial vehicle (UAV) imagery unlocks a great number of mapping and monitoring applications.
John Ray Bergado, Francesco Nex
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Using ILWIS Software for teaching Core Operations in Earth Observation [PDF]
, 2018 Computational methods in GIS and Earth Observation are an important part of the curricula in Geo - informatics. Apart from the theoretical foundations students need to get acquainted with the practical application of these methods in software.
Retsios, V. +5 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source