Results 151 to 160 of about 158,991 (313)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Site-specific apparent optimum air temperature for vegetation photosynthesis across the globe

Scientific Data
The apparent optimum air temperature for vegetation photosynthesis (Topt) is a key temperature parameter in terrestrial ecosystem models estimating daily photosynthesis or gross primary production (GPP, g C/m2/day).
Li Pan, Xiangming Xiao, Yuan Yao, Baihong Pan, Chenglong Yin, Cheng Meng, Yuanwei Qin, Chenchen Zhang   +7 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Use of near real time earth observation data infrastructures and open source tools for water resources monitoring and assessment [PDF]

, 2014
Since several years, a rapid and ever increasing public use of geo-information data derived from earth observation satellites is noted. The use of Google and Microsoft Virtual Earth engines can be seen as generic examples of this trend.
Budde, P.E.; id_orcid, Budde, P.E., Mannaerts, C.M., Maathuis, B.H.P.   +3 more
core  

Towards enhanced Sargassum monitoring in the Caribbean Sea

Scientific Reports
Monitoring Sargassum along the coasts of the Greater Caribbean has become essential due to recurrent blooms since 2018, which bring severe ecological, economic, and social impacts that accumulate yearly.
Javier Arellano-Verdejo, Hugo E. Lazcano-Hernandez, Jorge Prado Molina, Uriel de Jesús Mendoza Castillo, Víctor Manuel Jiménez Escudero, Francisco Javier Osorno Covarrubias, Gabriela Gómez Rodríguez, José Antonio Quintero Pérez, Steven Czitrom Baus, Iván Penié Rodríguez, Guadalupe Tapia Varela, Ilma Maclovia Huy Domínguez   +11 more
doaj   +1 more source

Reflection Symmetry Detection in Earth Observation Data. [PDF]

Sensors (Basel), 2023
Podgorelec D, Lukač L, Žalik B.
europepmc   +1 more source

Earth Observations for Geohazards [PDF]

, 2017
Earth Observations (EO) encompasses different types of sensors (e.g., SAR, LiDAR, Optical and multispectral) and platforms (e.g., satellites, aircraft, and Unmanned Aerial Vehicles) and enables us to monitor and model geohazards over regions at different scales in which ground observations may not be possible due to physical and/or political ...
Zhenhong Li (Ed.), Roberto Tomás (Ed.)
openaire   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source