Results 131 to 140 of about 158,991 (313)

Analysis of Lava from the Cumbre Vieja Volcano Using Remote Sensing Data from DESIS and Sentinel-2

Remote Sensing
On 19th September 2021, a protracted eruption of the Cumbre Vieja Volcano on the Canary Island of La Palma commenced and continued for a duration of 12 weeks. Lava flows starting from the rift zone at the mid-western flank of Cumbre Vieja advanced toward
Raquel De Los Reyes, Rudolf Richter, Simon Plank, David Marshall   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

China's Earth observing satellites for building a Digital Earth

International Journal of Digital Earth, 2012
Digital Earth is the inevitable outcome of the space era and evolutionary development of the information society, characterized by global coverage by Earth observing satellites.
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Monitoring Diesel Spills in Freezing Seawater under Windy Conditions Using C-Band Polarimetric Radar

Remote Sensing
The risk of oil spills in the Arctic is growing rapidly as anthropogenic activities increase due to climate-driven sea ice loss. Detecting and monitoring fuel spills in the marine environment is imperative for enacting an efficient response to mitigate ...
Mahdi Zabihi Mayvan, Elvis Asihene, Durell Desmond, Leah Hicks, Katarzyna Polcwiartek, Gary A. Stern, Dustin Isleifson   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Using colored dissolved organic matter fluorescence to trace Pacific-derived water in the Eastern Canadian Arctic

Scientific Reports
Low-salinity Pacific Water (PW) entering the Arctic Ocean through the Bering Strait is the second largest source of freshwater to the Arctic Ocean and dominates the freshwater inventory of Baffin Bay due to PW advection through Nares Strait and the ...
Igor A. Dmitrenko, Colin A. Stedmon, David G. Babb, Bert Rudels, Sergei A. Kirillov, Jens Ehn, Tonya Burgers, Dorthe Dahl-Jensen   +7 more
doaj   +1 more source

Application of remotely sensed data and landscape metrics to understand the impacts of rapid urban expansion on wetland ecosystems

Cogent Social Sciences
The rapid expansion of urban landscapes in less developed countries is causing severe ecological impacts on important ecosystems such as wetlands.
Mark Zvidzai, Sallie Yokwanda Mathema, Ratidzo Blessing Mapfumo, Knowledge K. Mawere, Aldridge N. Mazhindu, Kudzai Chirenje, Hardlife Muhoyi   +6 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source