Results 131 to 140 of about 6,907,046 (350)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Few-Shot Learning for Crop Mapping from Satellite Image Time Series

Remote Sensing
Recently, deep learning methods have achieved promising crop mapping results. Yet, their classification performance is constrained by the scarcity of labeled samples.
Sina Mohammadi, Mariana Belgiu, Alfred Stein   +2 more
doaj   +1 more source

Miscellaneous applications of deep learning based multi-sensor Earth observation

Multi-sensor Earth observation offers significant potential across several fields by combining data from diverse sources, providing an understanding of the Earth's dynamics.
Ahmad, Tahir, Yadav, Ashish, Saha, Sudipan   +2 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Responsible AI for Earth Observation

CoRR
The convergence of artificial intelligence (AI) and Earth observation (EO) technologies has brought geoscience and remote sensing into an era of unparalleled capabilities. AI's transformative impact on data analysis, particularly derived from EO platforms, holds great promise in addressing global challenges such as environmental monitoring, disaster ...
Pedram Ghamisi, Weikang Yu, Andrea Marinoni, Caroline M. Gevaert, Claudio Persello, Sivasakthy Selvakumaran, Manuela Girotto, Benjamin P. Horton, Philippe Rufin, Patrick Hostert, Fabio Pacifici, Peter M. Atkinson   +11 more
openaire   +3 more sources

Earth observation using SAR and social media images [PDF]

, 2017
Earth Observation (EO) is mostly carried out through centralized optical and synthetic aperture radar (SAR) missions. Despite the controlled quality of their products, such observation is restricted by the characteristics of the sensor platform, e.g.
Wang, Yuanyuan, Yuanyuan Wang, Zhu, Xiao Xiang, Xiao Xiang Zhu   +3 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source