Results 121 to 130 of about 158,108 (314)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Monitoring Diesel Spills in Freezing Seawater under Windy Conditions Using C-Band Polarimetric Radar

Remote Sensing
The risk of oil spills in the Arctic is growing rapidly as anthropogenic activities increase due to climate-driven sea ice loss. Detecting and monitoring fuel spills in the marine environment is imperative for enacting an efficient response to mitigate ...
Mahdi Zabihi Mayvan, Elvis Asihene, Durell Desmond, Leah Hicks, Katarzyna Polcwiartek, Gary A. Stern, Dustin Isleifson   +6 more
doaj   +1 more source

Observation Principles for an earth Observer

, 2014
Phenomenalism from the Greek phainomenon (appearance) philosophically means any system of thought that has to with appearances. If the descriptions and conclusions for an observation are altered in any way by conditions of perception due to phenomenalism, discombobulating science is created.
openaire   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Using colored dissolved organic matter fluorescence to trace Pacific-derived water in the Eastern Canadian Arctic

Scientific Reports
Low-salinity Pacific Water (PW) entering the Arctic Ocean through the Bering Strait is the second largest source of freshwater to the Arctic Ocean and dominates the freshwater inventory of Baffin Bay due to PW advection through Nares Strait and the ...
Igor A. Dmitrenko, Colin A. Stedmon, David G. Babb, Bert Rudels, Sergei A. Kirillov, Jens Ehn, Tonya Burgers, Dorthe Dahl-Jensen   +7 more
doaj   +1 more source

Application of remotely sensed data and landscape metrics to understand the impacts of rapid urban expansion on wetland ecosystems

Cogent Social Sciences
The rapid expansion of urban landscapes in less developed countries is causing severe ecological impacts on important ecosystems such as wetlands.
Mark Zvidzai, Sallie Yokwanda Mathema, Ratidzo Blessing Mapfumo, Knowledge K. Mawere, Aldridge N. Mazhindu, Kudzai Chirenje, Hardlife Muhoyi   +6 more
doaj   +1 more source

VCM throughput analysis for Earth Observation satellites in LEO orbit

, 2012
Since future systems will also be characterized by the on-board availability of a set of coding and modulation schemes at several spectral efficiencies and different SNR thresholds, the usage of Variable Coding Modulation (VCM) techniques can improve the
M. Bertinelli, M. Cossu, RIVA, CARLO GIUSEPPE, R. Roscigno, D. Capirone, D. Giancristofaro, G. Montorsi   +6 more
core  

Development and Validation of a Dense 18-Year Time Series of Surface Water Fraction Estimates from MODIS for the Mediterranean Region

, 2019
In this paper, we developed a time series of surface water fraction maps at 500 m spatial resolution and 8-day temporal resolution over 18 years (2000-2017) for the Mediterranean ...
Li, L (Faculty of Geo-Information Science and Earth Observation (ITC), University of Twente), Researcher
core   +1 more source

China's Earth observing satellites for building a Digital Earth

International Journal of Digital Earth, 2012
Digital Earth is the inevitable outcome of the space era and evolutionary development of the information society, characterized by global coverage by Earth observing satellites.
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source