Results 91 to 100 of about 253,500 (286)

Earth Sciences Are the Model Sciences of the Anthropocene

open access: yesPerspectives of Earth and Space Scientists
After 4.5 billion years as an evolving and dynamic planet, the Earth continues to evolve but with human‐altered dynamics. Earth scientists have special opportunities and responsibilities to accelerate our understanding of Earth's changes that are ...
Daniel D. Richter   +44 more
doaj   +1 more source

From multi-hazard early warning systems (MHEWS) to all-vulnerability warning systems (AVWS)

open access: yesiScience
Summary: Science, policy, and practice have long accepted that disasters occur due to vulnerabilities rather than hazards, yet approaches to warnings still tend to be hazard-focused.
Ilan Kelman, Carina J. Fearnley
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

MINUTES OF THE EARTH SCIENCE SECTION [PDF]

open access: yesSchool Science and Mathematics, 1919
n ...
openaire   +3 more sources

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

open access: yesFEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Characterization of the thermophilic xylanase Fsa02490Xyn from the hyperthermophile Fervidibacter sacchari belonging to glycoside hydrolase family 10

open access: yesFEBS Open Bio, EarlyView.
Fervidibacter sacchari is a member of the bacterial phylum Armatimonadota, only a few of which have been cultivated. It is a hyperthermophilic polysaccharide degradation specialist. We show that a secreted enzyme, Fsa02490Xyn, is an endoxylanase belonging to glycoside hydrolase family 10.
Nicole Torosian   +10 more
wiley   +1 more source

Use of Mohr diagrams to predict fracturing in rock masses, with applications for predicting sub-surface behavior

open access: yesiScience
Summary: Mohr diagrams are a simple and effective method that can help geoscientists consider, model, and predict the ranges of mechanical properties of rock, stresses, fluid pressures, and the resultant fractures that are likely to occur in the sub ...
D.C.P. Peacock   +2 more
doaj   +1 more source

Matrix: a complex amalgam of structures and functions in tumor microenvironment

open access: yesFEBS Open Bio, EarlyView.
The matrix is a dynamic, intricate three‐dimensional mesh of biomolecules with both structural and functional properties. This review deals with the complexity of this ‘molecular amalgam’ in the tumor microenvironment and highlights its importance in the maintenance and evolution of tumors by describing certain matrix biomolecules, such as ...
Spyros S. Skandalis   +3 more
wiley   +1 more source

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