Results 91 to 100 of about 250,403 (271)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Celebrating the Physics in Geophysics
, 2005 As 2005, the International Year of Physics, comes to an end, two physicists working primarily in geophysical research reflect on how geophysics is not an applied physics.
Anderson +4 more
core +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
The significance that space studies are making to all Earth sciences in the areas of geography, geodesy, cartography, geology, meteorology, oceanology, agronomy, and ecology is discussed.
Sidorenko, A. V.
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Latin American Journal of Sedimentology and Basin Analysis, 2021 The origin of Geomorphology can be referred to 2500 years ago when the ancient Greek, Roman, Arab and Chinese philosophers tried to comprehend the occurrence of earthquakes, volcanoes and the presence of seashells at high mountains elevations.
Diana G. Cuadrado
doaj +2 more sources
Transferring Google Earth observations to GIS-software : example from gully erosion study [PDF]
, 2013 High-resolution images available on Google Earth are increasingly being consulted in geographic studies. However, most studies limit themselves to visualizations or on-screen measurements.
Frankl, Amaury +3 more
core +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
How was it for you? A cross-disciplinary study of ‘troublesome knowledge’ as identified by undergraduate students and lecturers in Geography, Medical Science and Psychology [PDF]
, 2011 We carried out a small scale pilot study to determine whether participants would spontaneously identify Threshold Concepts (TC’s) and/or troublesome knowledge during open questioning on the characteristics of their disciplines.
Jamieson, Susan +2 more
core