Results 231 to 240 of about 881,123 (277)

AI‐Powered, Temperature‐Resolved Centrifugal Microfluidics for Rapid 3D Phase‐Diagram Generation of Biomolecular Condensates

Advanced Science, EarlyView.
By merging centrifugal microfluidics, precise temperature control, and AI image recognition, T‐PhaseMap transforms biomolecular condensate phase mapping into a rapid, temperature‐resolved workflow. It generates 3D composition–temperature phase diagrams within 30 min, resolves four phase states, and uncovers temperature‐dependent heparin sodium ...
Jiashuo Li, Pengjie Li, Kaiting Zhang, Yongqi Guo, Peng Chen, Bi‐Feng Liu, Yiwei Li   +6 more
wiley   +1 more source

MethyAnno: An Interpretable Automated Annotation Method Leveraging Multi‐Scale Information and Metric Learning Framework for scDNAm Data

Advanced Science, EarlyView.
MethyAnno enables robust and interpretable annotation of single‐cell DNA methylation data by integrating multi‐scale epigenetic information, bidirectional cross‐attention, and prototype‐based metric learning. The framework resolves rare and novel cell types across datasets while revealing cell‐type‐specific epigenetic signatures associated with disease
Yuhang Jia, Siyu Li, Songming Tang, Keju Gu, Shengquan Chen   +4 more
wiley   +1 more source

Changes in Eating Disorder Symptoms in Perinatal US Military Servicewomen. [PDF]

Int J Eat Disord
Thompson KA, Schrag R, Thalheimer AJ, Mains A, Rioux S, Thomas V, Sinkford Z, Klein DA, Haigney M, Tanofsky-Kraff M, Lavender JM.   +10 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Circadian Rhythm and Lipid Metabolism: The Role of the Gut Microbiota. [PDF]

Life (Basel)
Lv X, Liu H, Liu M, Liu C, Li Y, Ma J.
europepmc   +1 more source

Highly‐Time‐Resolved Measurements of Tryptophan's Distribution and Homeostatic Regulation in Live, Intact Animals

Advanced Science, EarlyView.
Using a novel, aptamer‐based biosensor, here we have performed 20‐s‐resolved, in situ measurements of plasma‐free tryptophan in the jugular veins of live rats (blue). This unprecedented time‐resolution provides insights into the regulation of tryptophan metabolism in live, intact animals.
Yuyang Wu, Chelsea N. Brown, Zeki Duman, Rose Mery Bakestani, Carl M. Kirkpatrick, Joao Hespanha, Tod Kippin, Kevin W. Plaxco   +7 more
wiley   +1 more source

Time-restricted eating, immunomodulation and ketone metabolism in humans. [PDF]

Metabolism
Macheret NA, Thota GP, Hengist A, Courville A, Chen KY, Brychta RJ, Klein RJ, Malandrino N, Puchalska P, Crawford PA, Duan D, Huang A, Recupero TC, Sullivan BS, Sack MN, Chung ST.   +15 more
europepmc   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

The diversity and consistency of what and when people eat. [PDF]

Nat Metab
Tran T, Manoogian ENC, Hou ZJ, Varshney S, Sui J, Laing KL, Fleischer JG, Panda S.   +7 more
europepmc   +1 more source

Altered late semantic processing of food stimuli in female anorexia nervosa and atypical anorexia nervosa patients. [PDF]

Front Hum Neurosci
Loizou P, Kaimakami S, Tomazou A, Panayiotou G, Zanos P, Junghöfer M, Paraskevopoulos E.   +6 more
europepmc   +1 more source