Results 21 to 30 of about 165,346 (280)

Rapid bedside inactivation of Ebola virus for safe nucleic acid tests [PDF]

, 2016
Rapid bedside inactivation of Ebola virus would be a solution for the safety of medical and technical staff, risk containment, sample transport and high-throughput or rapid diagnostic testing during an outbreak.
Bragstad, Karoline, Dudman, Susanne Gjeruldsen, Fomsgaard, Anders, Karlberg, Helen, Kran, Anne Marte Bakken, Lindegren, Gunnel, Mirazimi, Ali, Rosenstierne, Maiken Wors\uf8e, Salata, Cristiano, Stoltz, Malin Lundahl   +9 more
core   +2 more sources

The deployment of mobile diagnostic laboratories for Ebola virus disease diagnostics in Sierra Leone and Guinea

African Journal of Laboratory Medicine, 2021
Background: Ebola virus emerged in West Africa in December 2013. The ease of mobility, porous borders, and lack of public health infrastructure led to the largest Ebola virus disease (EVD) outbreak to date.
Lance D. Presser, Jeanette Coffin, Lamine Koivogui, Allan Campbell, Julian Campbell, Fatmata Barrie, Jone Ngobeh, Zein Souma, Samuel Sorie, Doris Harding, Alimou Camara, Pepe Tohonamou, Basala Traore, Frank A. Hamill, Joe Bogan, Sharon Altmann, Casey Ross, Jay Mansheim, Robert Hegerty, Scott Poynter, Scott Shearrer, Carmen Asbun, Brendan Karlstrand, Phil Davis, Jane Alam, David Roberts, Paul D. Stamper, Jean Ndjomou, Nadia Wauquier, Mohamed Koroma, Alhaji Munu, Jason McClintock, Mar Mar, True Burns, Stephen Krcha   +34 more
doaj   +1 more source

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Nature, 2016
The most recent Ebola virus outbreak in West Africa, which was unprecedented in the number of cases and fatalities, geographic distribution, and number of nations affected, highlights the need for safe, effective, and readily available antiviral agents ...
Travis K Warren, R. Jordan, Michael K. Lo, A. Ray, R. Mackman, V. Soloveva, D. Siegel, M. Perron, R. Bannister, H. Hui, Nate Larson, R. Strickley, Jay B. Wells, Kelly S. Stuthman, Sean A. van Tongeren, N. Garza, G. Donnelly, A. Shurtleff, Cary J. Retterer, D. Gharaibeh, Rouzbeh Zamani, Tara A. Kenny, Brett Eaton, Elizabeth C. Grimes, Lisa S. Welch, L. Gomba, C. Wilhelmsen, D. Nichols, J. Nuss, Elyse R. Nagle, Jeffrey R. Kugelman, G. Palacios, Edward M. Doerffler, Sean Neville, Ernest A. Carra, M. Clarke, Lijun Zhang, W. Lew, B. Ross, Q. Wang, K. Chun, Lydia Wolfe, D. Babusis, Yeojin Park, Kirsten M. Stray, Iva Trancheva, Joy Y. Feng, O. Barauskas, Yili Xu, Pamela Wong, Molly R. Braun, M. Flint, L. McMullan, Shan-Shan Chen, R. Fearns, S. Swaminathan, D. Mayers, C. Spiropoulou, William A. Lee, S. Nichol, T. Cihlář, S. Bavari   +61 more
semanticscholar   +1 more source

The laboratory health system and its response to the Ebola virus disease outbreak in Liberia

African Journal of Laboratory Medicine, 2016
The laboratory system in Liberia has generally been fragmented and uncoordinatedAccordingly, the country’s Ministry of Health established the National Reference Laboratoryto strengthen and sustain laboratory services. However, diagnostic testing services
Stephen B. Kennedy, Christine L. Wasunna, John B. Dogba, Philip Sahr, Candace B. Eastman, Fatorma K. Bolay, Gloria T. Mason, Mark W.S. Kieh   +7 more
doaj   +1 more source

Ebola Contact Tracing Study data [PDF]

, 2019
The collection contains four datasets captured in the Ebola Contact Tracing Study: [1] 'summary_data_cases' contains details of the 41 confirmed Ebola cases included in the study; [2] 'app_data_contacts' contains details of the 646 Ebola contacts ...
Danquah, Lisa, Hasham, Nadia, MacFarlane, Matthew, Weiss, Helen   +3 more
core   +1 more source

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

Viruses, 2019
Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug that shows broad-spectrum antiviral activity against several RNA viruses. This compound is currently under clinical development for the treatment of Ebola virus disease (
E. Tchesnokov, Joy Y. Feng, D. Porter, M. Götte   +3 more
semanticscholar   +1 more source

A review of strategies used to retain participants in clinical research during an infectious disease outbreak: The PREVAIL I Ebola vaccine trial experience

Contemporary Clinical Trials Communications, 2018
Introduction: This article describes a retrospective review of participant follow-up and retention strategies in the Partnership for Research on the Ebola Virus in Liberia (PREVAIL) I Vaccine Trial.
Sarah Browne, Tarweh Carter, Risa Eckes, Greg Grandits, Melvin Johnson, Irene Moore, Laura McNay   +6 more
doaj   +1 more source

Pre-Ebola virus disease laboratory system and related challenges in Liberia

African Journal of Laboratory Medicine, 2016
Prior to the Ebola virus disease outbreak in Liberia, the laboratory system was duplicativefragmented and minimally coordinated. The National Reference Laboratory was conceptualisedto address the existing challenges by promoting the implementation of ...
Stephen B. Kennedy, John B. Dogba, Christine L. Wasunna, Philip Sahr, Candace B. Eastman, Fatorma K. Bolay, Gloria T. Mason, Mark W.S. Kieh   +7 more
doaj   +1 more source

Real-time, portable genome sequencing for Ebola surveillance

Nature, 2016
The Ebola virus disease epidemic in West Africa is the largest on record, responsible for over 28,599 cases and more than 11,299 deaths. Genome sequencing in viral outbreaks is desirable to characterize the infectious agent and determine its evolutionary
J. Quick, N. Loman, S. Duraffour, J. Simpson, E. Severi, L. Cowley, J. A. Boré, Raymond Koundouno, G. Dudas, A. Mikhail, N. Ouédraogo, B. Afrough, A. Bah, J. H. Baum, B. Becker-Ziaja, J. Boettcher, Mar Cabeza-Cabrerizo, Alvaro Camino-Sanchez, Lisa L. Carter, J. Doerrbecker, T. Enkirch, Isabel Graciela García Dorival, Nicole Hetzelt, J. Hinzmann, Tobias Holm, L. Kafetzopoulou, Michel Koropogui, Abigail Kosgey, Eeva Kuisma, C. Logue, A. Mazzarelli, S. Meisel, M. Mertens, J. Michel, D. Ngabo, K. Nitzsche, Elisa Pallash, L. Patrono, J. Portmann, Johanna Repits, Natasha Y. Rickett, A. Sachse, Katrin Singethan, I. Vitoriano, Rahel L Yemanaberhan, E. Zekeng, Racine Trina, A. Bello, A. Sall, O. Faye, O. Faye, N. Magassouba, Cecelia V. Williams, Victoria Amburgey, L. Winona, E. Davis, J. Gerlach, F. Washington, V. Monteil, M. Jourdain, M. Bererd, Alimou Camara, H. Somlaré, Abdoulaye Camara, Marianne Gérard, G. Bado, Bernard Baillet, D. Delaune, K. Nebie, A. Diarra, Yacouba Savane, R. Pallawo, G. Gutierrez, N. Milhano, Isabelle Roger, Christopher J Williams, Facinet Yattara, Kuiama Lewandowski, Jamie Taylor, P. Rachwal, D. Turner, G. Pollakis, J. Hiscox, D. Matthews, M. O’Shea, A. Johnston, Duncan R. Wilson, E. Hutley, E. Smit, A. di Caro, R. Woelfel, K. Stoecker, E. Fleischmann, Martin Gabriel, S. Weller, L. Koivogui, B. Diallo, S. Keita, A. Rambaut, P. Formenty, S. Gunther, M. Carroll   +101 more
semanticscholar   +1 more source

The journey of remdesivir: from Ebola to COVID-19

Drugs in Context, 2020
Countries around the world are currently fighting the coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Joe Pardo, Ashutosh M. Shukla, Gajapathiraju Chamarthi, A. Gupte   +3 more
semanticscholar   +1 more source