Results 71 to 80 of about 3,723 (172)

Exploring the simultaneous σ-hole/π-hole bonding characteristics of a Br...π interaction in an ebselen derivative via experimental and theoretical electron-density analysis

IUCrJ, 2018
In this study, the nature and characteristics of a short Br...π interaction observed in an ebselen derivative, 2-(2-bromophenyl)benzo[d][1,2]selenazol-3(2H)-one, has been explored.
Rahul Shukla, Nicolas Claiser, Mohamed Souhassou, Claude Lecomte, Shah Jaimin Balkrishna, Sangit Kumar, Deepak Chopra   +6 more
doaj   +1 more source

Synthesis, anticancer activity and molecular modeling of new NSAIDs-Ebselen derivatives as potential TrxR1 inhibitor

Results in Chemistry
Thioredoxin reductase 1 (TrxR1) is a key anticancer drug target whose inhibition can trigger reactive oxygen species (ROS)-mediated apoptosis in human cancer cells.
Min Zhong, Yingxue Bi, Jiaxu Zhang, Shaolei Li, Yousong Nie, Xianran He, Liang Li   +6 more
doaj   +1 more source

Discovery of Ebselen as an Inhibitor of 6PGD for Suppressing Tumor Growth

Cancer Management and Research, 2020
Qi Feng,1 Xiuru Li,1 Wenjing Sun,1 Yubo Li,2 Yu Yuan,2 Baozhang Guan,1 Shuai Zhang3 1The First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of China; 2Tianjin ...
Feng Q, Li X, Sun W, Li Y, Yuan Y, Guan B, Zhang S   +6 more
doaj  

The effect of three urease inhibitors on H. pylori viability, urease activity and urease gene expression

Frontiers in Microbiology
BackgroundTreatment of Helicobacter pylori (H. pylori) infections is challenged by antibiotic resistance. The urease enzyme contributes to H. pylori colonization in the gastric acidic environment by producing a neutral microenvironment.
Hanaa Shaalan, Maya Azrad, Avi Peretz, Avi Peretz   +3 more
doaj   +1 more source

Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs

Drug Design, Development and Therapy, 2017
Yuren Wang,1 Jason Wallach,2 Stephanie Duane,1 Yuan Wang,1 Jianghong Wu,1 Jeffrey Wang,1 Adeboye Adejare,2 Haiching Ma1 1Reaction Biology Corp., Malvern, 2Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the ...
Wang Y, Wallach J, Duane S, Wang Y, Wu J, Wang J, Adejare A, Ma H   +7 more
doaj  

Perspective: Beta Cell Glucose Toxicity in Type 2 Diabetes: Nrf2 and the Endogenous Antioxidant Response. [PDF]

Antioxidants (Basel)
Robertson RP.
europepmc   +1 more source

Role of ROS, soluble guanylate cyclase and cGMP in mouse lung development during hyperoxia. [PDF]

Am J Physiol Heart Circ Physiol
Nguyen ML, Taylor JM, Dudley VJ, Waypa GB, Schumacker PT.   +4 more
europepmc   +1 more source

No Evidence of Moderated Impulsivity Following Administration of the IMPase Inhibitor Ebselen in Healthy Adults. [PDF]

Hum Psychopharmacol
John MPG, Earnshaw L, Shankar NG, Raja JS, Davies TJ, Cowen PJ, Sharp T, Salmoiraghi A, Rogers RD.   +8 more
europepmc   +1 more source

The Selenium Paradox: From Evolutionary Redox Chemistry to Medicinal Chemistry. [PDF]

Int J Mol Sci
Proto M, Giraldi C, Santi C.
europepmc   +1 more source

Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimics. [PDF]

ACS Med Chem Lett
Yu Z, Shi W, Qian Z, Mei X, Huang X, Chen X, Wang W, Zhang T, Chen X, Li Z, Zheng C.   +10 more
europepmc   +1 more source