Results 71 to 80 of about 3,624 (175)

N-(2-Methylphenyl)-1,2-benzoselenazol-3(2H)-one

Acta Crystallographica Section E, 2013
In the title Ebselen [systematic name: (2-phenyl-1,2-benzoisoselenazol-3-(2H)-one)] analogue, C14H11NOSe, the benzisoselenazolyl moiety (r.m.s. deviation = 0.0209 Å) is nearly perpendicular to the N-arenyl ring, making a dihedral angle of 78 ...
Xu Zhu, Ying Xu, Hongfei Han, Zhiqiang Guo, Xuehong Wei   +4 more
doaj   +1 more source

Synthesis, anticancer activity and molecular modeling of new NSAIDs-Ebselen derivatives as potential TrxR1 inhibitor

Results in Chemistry
Thioredoxin reductase 1 (TrxR1) is a key anticancer drug target whose inhibition can trigger reactive oxygen species (ROS)-mediated apoptosis in human cancer cells.
Min Zhong, Yingxue Bi, Jiaxu Zhang, Shaolei Li, Yousong Nie, Xianran He, Liang Li   +6 more
doaj   +1 more source

Discovery of Ebselen as an Inhibitor of 6PGD for Suppressing Tumor Growth

Cancer Management and Research, 2020
Qi Feng,1 Xiuru Li,1 Wenjing Sun,1 Yubo Li,2 Yu Yuan,2 Baozhang Guan,1 Shuai Zhang3 1The First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of China; 2Tianjin ...
Feng Q, Li X, Sun W, Li Y, Yuan Y, Guan B, Zhang S   +6 more
doaj  

The Comparasion of The Effects of Novel Antioxidant Compounds Ebselen, Isorhamnetin, and Genistein on the Cardiovascular System

Recent Trends in Pharmacology
Purpose: This study evaluated the effects of antioxidants Ebselen (EBS), Isorhamnetin (ISO), and Genistein (GEN) on oxidative stress (OS), hemodynamic parameters, and cardiovascular histopathology in rats.Methods: Forty adult Wistar rats were randomized ...
Onural Özhan, Ahmet Acet, Azibe Yıldız, Necip Ermiş, Burhan Ateş, Nigar Vardı, Cemil Çolak, Mehmet Gunata, Hakan Parlakpınar   +8 more
doaj   +1 more source

Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs

Drug Design, Development and Therapy, 2017
Yuren Wang,1 Jason Wallach,2 Stephanie Duane,1 Yuan Wang,1 Jianghong Wu,1 Jeffrey Wang,1 Adeboye Adejare,2 Haiching Ma1 1Reaction Biology Corp., Malvern, 2Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the ...
Wang Y, Wallach J, Duane S, Wang Y, Wu J, Wang J, Adejare A, Ma H   +7 more
doaj  

Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimics. [PDF]

ACS Med Chem Lett
Yu Z, Shi W, Qian Z, Mei X, Huang X, Chen X, Wang W, Zhang T, Chen X, Li Z, Zheng C.   +10 more
europepmc   +1 more source

Fructose 1-phosphate inhibits mannose phosphate isomerase to suppress hepatocellular carcinogenesis. [PDF]

Signal Transduct Target Ther
Wang Y, Zhang X, Wang N, Jiang H, Liang N, Du C, Yin C, Li R, Zhang L, Tu Q, Lv J, Ma H, Xu X, Kong X, Chen X, Liu G, Chen S, Xu H, Qin J, Li S, Tao Y, Zeng S, Shen H, Goncalves MD, Zhong S, Yin H.   +25 more
europepmc   +1 more source

Obesity-driven phosphatidylethanolamine dysregulation impairs neuroimmune crosstalk and accelerates Alzheimer's pathogenesis. [PDF]

Mol Neurodegener
Yang L, Sheng J, Qi S, Yin Z, Chan M, Cao Y, Zhao H, Wan Z, Chan B, Ahn JY, Yu X, Vasquez M, Xu S, Han X, Xia W, Hsueh WA, Wong STC.   +16 more
europepmc   +1 more source

Establishment of a green fluorescent protein (GFP)-based reporter for picornaviral 3C proteases. [PDF]

J Virol
Hirano J, Hayashi T, Someya Y, Okada K, Uemura K, Yeh MT, Ono C, Taguwa S, Matsuura Y.   +8 more
europepmc   +1 more source

Ebselen Suppresses Breast Cancer Tumorigenesis by Inhibiting YTHDF1-Mediated c-Fos Expression. [PDF]

Int J Mol Sci
Vasukutty A, Bhattarai PY, Choi HS.
europepmc   +1 more source