Results 61 to 70 of about 3,624 (175)

Ebselen nanoemulgel for the treatment of topical fungal infection

European Journal of Pharmaceutical Sciences, 2020
Superficial mycoses are the fungal infections of skin, hair and nail which affect thousands of people worldwide. Emerging resistance to azole antifungals is a common problem in the treatment of superficial or systemic fungal infection. Ebselen (EB), an organoselenium compound, has demonstrated promising activity against pathogenic yeasts.
Richa Vartak, Suvidha Menon, Manali Patki, Blase Billack, Ketan Patel   +4 more
openaire   +2 more sources

Use of ebselen as a neuroprotective agent in rat spinal cord subjected to traumatic injury

Neural Regeneration Research, 2019
Spinal cord injury (SCI) causes disturbances of motor skills. Free radicals have been shown to be essential for the development of spinal cord trauma. Despite some progress, until now no effective pharmacological therapies against SCI have been verified.
Wojciech Slusarczyk, Edyta Olakowska, Magdalena Larysz-Brysz, Izabella Woszczycka-Korczyńska, Daria Gendosz de Carrillo, Władysław P Węglarz, Joanna Lewin-Kowalik, Wiesław Marcol   +7 more
doaj   +1 more source

Cancer therapy‐induced ototoxicity: Current challenges and emerging management strategies

Animal Models and Experimental Medicine, Volume 9, Issue 4, Page 712-734, April 2026.
This review comprehensively examines the key risk factors for cancer therapy‐induced ototoxicity, including cumulative drug dose, genetic susceptibility, and combined treatment regimens. It highlights current challenges in ototoxicity monitoring, such as insufficient timeliness and limited clinical adoption, and advocates for standardized auditory ...
Yuqi Huang, Baoying Xu, Xinru Chen, Yu Chen, Dehong Yu   +4 more
wiley   +1 more source

The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

Nature Communications, 2018
Mutations in superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS). Here the authors present the SOD1 crystal structure bound to the small cysteine-reactive molecule ebselen and show that ebselen is a chaperone for SOD1.
Michael J. Capper, Gareth S. A. Wright, Letizia Barbieri, Enrico Luchinat, Eleonora Mercatelli, Luke McAlary, Justin J. Yerbury, Paul M. O’Neill, Svetlana V. Antonyuk, Lucia Banci, S. Samar Hasnain   +10 more
doaj   +1 more source

Cytotoxic, Genotoxic, and Mutagenic Effects of Organotellurane RF07 in Female Swiss Mice (Mus musculus)

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT The organotellurane RF07 (RF07) is an organic compound containing tellurium, a rare semi‐metal, and its leishmanicidal and antimalarial activity has already been reported in previous studies. This study evaluated the toxic effects of RF07 at 0.42, 21.37, and 42.75 mg/kg using comet assay, micronucleus test, and hematological/biochemical tests ...
Felipe Emannuel Alvino de Jesus, Octávio Augusto de Carvalho Maia, Rosália Maria Tôrres de Lima, Ag‐Anne Pereira Melo de Meneses, Audinei de Sousa Moura, Antonielly Campinho dos Reis, Maria Luísa Lima Barreto do Nascimento, Taline Alves Nobre, Athanara Alves de Sousa, Shamya Gabriella Corrêa Coelho, Glissia Lysandra dos Santos Marciel, Isabela Ribeiro de Sá Guimarães Nolêto, Adriana Maria Viana Nunes, Rodrigo Luiz Oliveira Rodrigues Cunha, Pedro Marcos de Almeida, Diego Di Felipe Ávila Alcantara, João Marcelo de Castro e Sousa   +16 more
wiley   +1 more source

Next‐Generation Antioxidant Strategies: From Nanoformulations to Gene‐Targeted Therapies

cScience, Volume 2, Issue 1, March 2026.
ABSTRACT Antioxidants play a pivotal role in neutralizing oxidative stress, a key factor in aging and chronic diseases such as cancer, cardiovascular disorders, and neurodegeneration. Although traditional antioxidants such as vitamins C and E, polyphenols, and endogenous enzymes have shown efficacy in laboratory and clinical studies, their therapeutic ...
Lina M. Shaker, Ahmed Al‐Amiery
wiley   +1 more source

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Cell Reports, 2020
Summary: Excessive iron accumulation in the heart causes iron overload cardiomyopathy (IOC), which initially presents as diastolic dysfunction and arrhythmia but progresses to systolic dysfunction and end-stage heart failure when left untreated. However,
June-Wha Rhee, Hyoju Yi, Dilip Thomas, Chi Keung Lam, Nadjet Belbachir, Lei Tian, Xulei Qin, Jessica Malisa, Edward Lau, David T. Paik, Youngkyun Kim, Beatrice SeungHye Choi, Nazish Sayed, Karim Sallam, Ronglih Liao, Joseph C. Wu   +15 more
doaj   +1 more source

Effects of ebselen addition on emotional processing and brain neurochemistry in depressed patients unresponsive to antidepressant medication

Translational Psychiatry
Lithium is an effective augmenting agent for depressed patients with inadequate response to standard antidepressant therapy, but numerous adverse effects limit its use.
Fitri Fareez Ramli, Nisha Singh, Uzay E. Emir, Luca M. Villa, Shona Waters, Catherine J. Harmer, Philip J. Cowen, Beata R. Godlewska   +7 more
doaj   +1 more source

Reduction of Diphenyl Diselenide and Analogs by Mammalian Thioredoxin Reductase Is Independent of Their Gluthathione Peroxidase-Like Activity: A Possible Novel Pathway for Their Antioxidant Activity

Molecules, 2010
Since the successful use of the organoselenium drug ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there have been concerted efforts geared towards understanding the precise mechanism of ...
João Batista Teixeira Rocha, Diego Alves, Lisiane Oliveira Porciúncula, Jéssie Haigert Sudati, Caroline Wagner, Andressa Sausen de Freitas, Alessandro de Souza Prestes, Ige Joseph Kade   +7 more
doaj   +1 more source