Results 61 to 70 of about 3,723 (172)

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, Volume 2, Issue 2, June 2026.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, Volume 7, Issue 3, June 2026.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Ebselen nanoemulgel for the treatment of topical fungal infection

European Journal of Pharmaceutical Sciences, 2020
Superficial mycoses are the fungal infections of skin, hair and nail which affect thousands of people worldwide. Emerging resistance to azole antifungals is a common problem in the treatment of superficial or systemic fungal infection. Ebselen (EB), an organoselenium compound, has demonstrated promising activity against pathogenic yeasts.
Richa Vartak, Suvidha Menon, Manali Patki, Blase Billack, Ketan Patel   +4 more
openaire   +2 more sources

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Effects of ebselen addition on emotional processing and brain neurochemistry in depressed patients unresponsive to antidepressant medication

Translational Psychiatry
Lithium is an effective augmenting agent for depressed patients with inadequate response to standard antidepressant therapy, but numerous adverse effects limit its use.
Fitri Fareez Ramli, Nisha Singh, Uzay E. Emir, Luca M. Villa, Shona Waters, Catherine J. Harmer, Philip J. Cowen, Beata R. Godlewska   +7 more
doaj   +1 more source

Reduction of Diphenyl Diselenide and Analogs by Mammalian Thioredoxin Reductase Is Independent of Their Gluthathione Peroxidase-Like Activity: A Possible Novel Pathway for Their Antioxidant Activity

Molecules, 2010
Since the successful use of the organoselenium drug ebselen in clinical trials for the treatment of neuropathological conditions associated with oxidative stress, there have been concerted efforts geared towards understanding the precise mechanism of ...
João Batista Teixeira Rocha, Diego Alves, Lisiane Oliveira Porciúncula, Jéssie Haigert Sudati, Caroline Wagner, Andressa Sausen de Freitas, Alessandro de Souza Prestes, Ige Joseph Kade   +7 more
doaj   +1 more source

N-(2-Methylphenyl)-1,2-benzoselenazol-3(2H)-one

Acta Crystallographica Section E, 2013
In the title Ebselen [systematic name: (2-phenyl-1,2-benzoisoselenazol-3-(2H)-one)] analogue, C14H11NOSe, the benzisoselenazolyl moiety (r.m.s. deviation = 0.0209 Å) is nearly perpendicular to the N-arenyl ring, making a dihedral angle of 78 ...
Xu Zhu, Ying Xu, Hongfei Han, Zhiqiang Guo, Xuehong Wei   +4 more
doaj   +1 more source

Electrical Stimulation Degenerated Cochlear Synapses Through Oxidative Stress in Neonatal Cochlear Explants

Frontiers in Neuroscience, 2019
Neurostimulation devices use electrical stimulation (ES) to substitute, supplement or modulate neural function. However, the impact of ES on their modulating structures is largely unknown.
Qiong Liang, Qiong Liang, Na Shen, Na Shen, Na Shen, Bin Lai, Changjian Xu, Zengjun Sun, Zhengmin Wang, Zhengmin Wang, Shufeng Li, Shufeng Li   +11 more
doaj   +1 more source

Crucial Role of Selenium in the Virucidal Activity of Benzisoselenazol-3(2H)-ones and Related Diselenides

Molecules, 2010
Various N-substituted benzisoselenazol-3(2H)-ones and their non-selenium-containing analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity ...
Jacek Mlochowski, Magdalena Pietka-Ottlik, Piotr Potaczek, Egbert Piasecki   +3 more
doaj   +1 more source