Results 41 to 50 of about 3,723 (172)

Ebselen improves fungal keratitis through exerting anti-inflammation, anti-oxidative stress, and antifungal effects

Redox Biology
Fungal keratitis is a severely vision-threatening corneal infection, where the prognosis depends on both fungal virulence and host immune defense. Inappropriate host responses can induce substantial inflammatory damage to the cornea.
Bing Yu, Qian Wang, Lina Zhang, Jing Lin, Zhuhui Feng, Ziyi Wang, Lingwen Gu, Xue Tian, Songying Luan, Cui Li, Guiqiu Zhao   +10 more
doaj   +1 more source

Characterization of synergistic antibacterial effect of silver nanoparticles and ebselen

Artificial Cells, Nanomedicine, and Biotechnology, 2019
The emerging and spreading of multi-drug resistant (MDR) bacteria have been becoming one of the most severe threats to human health. Enhancing oxidative stress as mimicking immune system was considered as a potential strategy to fight against infection ...
Xueqing Chen, Heming Chen, Hongying Zhang, Yanjuan Peng, Fuchang Deng, Jiye Gao, Chunli Chai, Song Tang, Xin Zuo, Jun Lu, Huamao Du   +10 more
doaj   +1 more source

In vitro activity of non-antibiotic drugs against Staphylococcus aureus clinical strains

Journal of Global Antimicrobial Resistance, 2021
: Objectives: We hypothesised that one or more of the non-antibiotic candidates selected for this study would demonstrate antibiotic activity against Staphylococcus aureus.
Natalie K. Boyd, Grace C. Lee, Chengwen Teng, Christopher R. Frei   +3 more
doaj   +1 more source

Nanoparticles in Periodontology and Implant Dentistry: From Mechanisms to Clinical Applications

Journal of Periodontal Research, EarlyView.
Nanotechnology holds significant promise in improving dental care, yet there is a need for more reliable clinical studies to validate its effectiveness and safety. ABSTRACT Recent advances in nanotechnology are reshaping the landscape of periodontology and implant dentistry, particularly through the application of nanoparticles (NPs).
Chun Xu, Yuan Chen, Mario Romandini, Håvard Jostein Haugen, Sašo Ivanovski   +4 more
wiley   +1 more source

Paeonol Alleviate Cisplatin‐ and Noise‐Induced Hearing Loss by Preserving Hair Cell Ribosome Biogenesis

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Paeonol protects against cisplatin‐ and noise‐induced hearing loss by mitigating oxidative damage and preserving protein homeostasis in cochlear hair cells, revealing a novel mechanism involving ribosome biogenesis. ABSTRACT Background Hearing loss primarily results from irreversible cochlear hair cell (HC) damage caused by factors such as noise, aging,
Minhui Xia, Tianshi Sun, Wenyu Hou, Yiyun Lou, Yunjie Li, Hua Jiang, Hui Chai, Jiaoyao Ma, Mingyu Xia   +8 more
wiley   +1 more source

Nucleophile Exchange Mechanistic Paths in Chalcogenolate‐Dichalcogenide Systems: Insight From Computational Chemistry

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
The change of the chalcogen! This computational study explores trends in Group 16 nucleophile exchange model reactions, providing mechanistic insight in gas phase and in solvent as well as biological implications, which can guide the design of improved biomimetic catalysts.
Alessandro Rubbi, Andrea Trovato, Laura Orian   +2 more
wiley   +1 more source

Repurposing High-Throughput Screening Identifies Unconventional Drugs with Antibacterial and Antibiofilm Activities against Pseudomonas aeruginosa under Experimental Conditions Relevant to Cystic Fibrosis

Microbiology Spectrum, 2023
Pseudomonas aeruginosa is the most common pathogen infecting cystic fibrosis (CF) lungs, causing acute and chronic infections. Intrinsic and acquired antibiotic resistance allow P.
Giovanni Di Bonaventura, Veronica Lupetti, Andrea Di Giulio, Maurizio Muzzi, Alessandra Piccirilli, Lisa Cariani, Arianna Pompilio   +6 more
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Synergistic antibacterial effect of silver and ebselen against multidrug‐resistant Gram‐negative bacterial infections

EMBO Molecular Medicine, 2017
Multidrug‐resistant (MDR) Gram‐negative bacteria account for a majority of fatal infections, and development of new antibiotic principles and drugs is therefore of outstanding importance.
Lili Zou, Jun Lu, Jun Wang, Xiaoyuan Ren, Lanlan Zhang, Yu Gao, Martin E Rottenberg, Arne Holmgren   +7 more
doaj   +1 more source

In Vitro Activity of Ebselen and Diphenyl Diselenide Alone and in Combination with Drugs against Trichophyton mentagrophytes Strains

Pharmaceutics, 2022
Background: Dermatophytoses are one of the most prevalent infectious diseases in the world for which the pace of developing new drugs has not kept pace with the observed therapeutic problems.
Sebastian Gnat, Dominik Łagowski, Mariusz Dyląg, Grzegorz Jóźwiak, Aleksandra Trościańczyk, Aneta Nowakiewicz   +5 more
doaj   +1 more source