Results 31 to 40 of about 3,624 (175)

The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Lens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this site are referred as LEDGF-IN inhibitors (LEDGINs).
Da-Wei Zhang, Hao-Li Yan, Xiao-Shuang Xu, Lei Xu, Zhi-Hui Yin, Shan Chang, Heng Luo   +6 more
doaj   +1 more source

Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats

Biomolecules & Biomedicine, 2015
Ebselen is an organoselenium compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of ebselen pretreatment in rats with experimental sciatic nerve ischemia-reperfusion (I/R) injury.
Filiz Ozyigit, Aysegul Kucuk, Sezer Akcer, Murat Tosun, Emel Fatma Kocak, Cengiz Kocak, Ahmet Kocak, Hasan Metineren, Osman Genc   +8 more
doaj   +1 more source

Spray-Dried Inhalable Microparticles Combining Remdesivir and Ebselen against SARS-CoV-2 Infection

Pharmaceutics, 2023
There is a continuous effort to develop efficient treatments for coronavirus disease 2019 (COVID-19) and other viral respiratory diseases. Among the different strategies, inhaled treatment is considered one of the most logical and efficient approaches to
Tushar Saha, Shubhra Sinha, Rhodri Harfoot, Miguel E. Quiñones-Mateu, Shyamal C. Das   +4 more
doaj   +1 more source

Ebselen in Acute Ischemic Stroke [PDF]

Stroke, 1998
Background and Purpose —The effect of ebselen, a seleno-organic compound with antioxidant activity through a glutathione peroxidase–like action, on the outcome of acute ischemic stroke was evaluated in a multicenter, placebo-controlled, double-blind clinical trial. Methods —Patients
Takenori Yamaguchi, Keiji Sano, Kintomo Takakura, Isamu Saito, Yukito Shinohara, Takao Asano, Hajime Yasuhara   +6 more
openaire   +1 more source

Ebselen oxide and derivatives are new allosteric HER2 inhibitors for HER2‐positive cancers

Molecular Oncology, 2023
Human epidermal growth factor receptor 2 (ErbB2/HER2) is a tyrosine kinase receptor that is overexpressed in 25% of primary human breast cancers, as well as in multiple other cancers. HER2‐targeted therapies improved progression‐free and overall survival
Lucas Blasquez, Haniaa Bouzinba‐Segard, Sandrine Bourdoulous, Camille Faure   +3 more
doaj   +1 more source

Discovery of ebselen as an inhibitor of Cryptosporidium parvum glucose-6-phosphate isomerase (CpGPI) by high-throughput screening of existing drugs

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Cryptosporidium parvum is a water-borne and food-borne apicomplexan pathogen. It is one of the top four diarrheal-causing pathogens in children under the age of five in developing countries, and an opportunistic pathogen in immunocompromised individuals.
Rana Eltahan, Fengguang Guo, Haili Zhang, Lixin Xiang, Guan Zhu   +4 more
doaj   +1 more source

Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems

The Chemical Record, EarlyView.
Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Romelly Eugenia Rojas Ramírez, Tielle Moraes de Almeida, Daiani Canabarro Leite, Gilson Zeni   +3 more
wiley   +1 more source

Ebselen Optimized the Therapeutic Effects of Silver Nanoparticles for Periodontal Treatment

International Journal of Nanomedicine, 2023
Ye Liang,1– 4,* Bing Wang,1– 4,* Qing Yu,1– 4 Weijia Wang,1– 4 Shaohua Ge,1– 4 Jinlong Shao1– 4 1Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People’s Republic ...
Liang Y, Wang B, Yu Q, Wang W, Ge S, Shao J   +5 more
doaj  

In vitro activity of non-antibiotic drugs against Staphylococcus aureus clinical strains

Journal of Global Antimicrobial Resistance, 2021
: Objectives: We hypothesised that one or more of the non-antibiotic candidates selected for this study would demonstrate antibiotic activity against Staphylococcus aureus.
Natalie K. Boyd, Grace C. Lee, Chengwen Teng, Christopher R. Frei   +3 more
doaj   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source