Results 31 to 40 of about 3,723 (172)

Different dose-dependent effects of ebselen in sciatic nerve ischemia-reperfusion injury in rats

Biomolecules & Biomedicine, 2015
Ebselen is an organoselenium compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of ebselen pretreatment in rats with experimental sciatic nerve ischemia-reperfusion (I/R) injury.
Filiz Ozyigit, Aysegul Kucuk, Sezer Akcer, Murat Tosun, Emel Fatma Kocak, Cengiz Kocak, Ahmet Kocak, Hasan Metineren, Osman Genc   +8 more
doaj   +1 more source

The selenium-containing drug ebselen potently disrupts LEDGF/p75-HIV-1 integrase interaction by targeting LEDGF/p75

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Lens-epithelium-derived growth-factor (LEDGF/p75)-binding site on HIV-1 integrase (IN), is an attractive target for antiviral chemotherapy. Small-molecule compounds binding to this site are referred as LEDGF-IN inhibitors (LEDGINs).
Da-Wei Zhang, Hao-Li Yan, Xiao-Shuang Xu, Lei Xu, Zhi-Hui Yin, Shan Chang, Heng Luo   +6 more
doaj   +1 more source

Mechanistic Insight into SARS-CoV-2 M^pro Inhibition by Organoselenides: The Ebselen Case Study

Applied Sciences, 2021
The main protease (Mpro) of SARS-CoV-2 is a current target for the inhibition of viral replication. Through a combined Docking and Density Functional Theory (DFT) approach, we investigated in-silico the molecular mechanism by which ebselen (IUPAC: 2 ...
Andrea Madabeni, Pablo Andrei Nogara, Folorunsho Bright Omage, João Batista Teixeira Rocha, Laura Orian   +4 more
doaj   +1 more source

Spray-Dried Inhalable Microparticles Combining Remdesivir and Ebselen against SARS-CoV-2 Infection

Pharmaceutics, 2023
There is a continuous effort to develop efficient treatments for coronavirus disease 2019 (COVID-19) and other viral respiratory diseases. Among the different strategies, inhaled treatment is considered one of the most logical and efficient approaches to
Tushar Saha, Shubhra Sinha, Rhodri Harfoot, Miguel E. Quiñones-Mateu, Shyamal C. Das   +4 more
doaj   +1 more source

Discovery of ebselen as an inhibitor of Cryptosporidium parvum glucose-6-phosphate isomerase (CpGPI) by high-throughput screening of existing drugs

International Journal for Parasitology: Drugs and Drug Resistance, 2018
Cryptosporidium parvum is a water-borne and food-borne apicomplexan pathogen. It is one of the top four diarrheal-causing pathogens in children under the age of five in developing countries, and an opportunistic pathogen in immunocompromised individuals.
Rana Eltahan, Fengguang Guo, Haili Zhang, Lixin Xiang, Guan Zhu   +4 more
doaj   +1 more source

Ebselen oxide and derivatives are new allosteric HER2 inhibitors for HER2‐positive cancers

Molecular Oncology, 2023
Human epidermal growth factor receptor 2 (ErbB2/HER2) is a tyrosine kinase receptor that is overexpressed in 25% of primary human breast cancers, as well as in multiple other cancers. HER2‐targeted therapies improved progression‐free and overall survival
Lucas Blasquez, Haniaa Bouzinba‐Segard, Sandrine Bourdoulous, Camille Faure   +3 more
doaj   +1 more source

Ebselen in Acute Ischemic Stroke [PDF]

Stroke, 1998
Background and Purpose —The effect of ebselen, a seleno-organic compound with antioxidant activity through a glutathione peroxidase–like action, on the outcome of acute ischemic stroke was evaluated in a multicenter, placebo-controlled, double-blind clinical trial. Methods —Patients
Takenori Yamaguchi, Keiji Sano, Kintomo Takakura, Isamu Saito, Yukito Shinohara, Takao Asano, Hajime Yasuhara   +6 more
openaire   +1 more source

Ebselen Optimized the Therapeutic Effects of Silver Nanoparticles for Periodontal Treatment

International Journal of Nanomedicine, 2023
Ye Liang,1– 4,* Bing Wang,1– 4,* Qing Yu,1– 4 Weijia Wang,1– 4 Shaohua Ge,1– 4 Jinlong Shao1– 4 1Department of Periodontology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People’s Republic ...
Liang Y, Wang B, Yu Q, Wang W, Ge S, Shao J   +5 more
doaj  

Iso‐Tellurazole N‐Oxides Assemble Adaptively Folded Macrocyclic Dodecamers

Chemistry – A European Journal, EarlyView.
Te…O Chalcogen bonding links twelve molecules into a ring that wraps itself around molecular guests. ABSTRACT Self‐assembled macrocyclic dodecamers were found in the crystals of new pseudo‐polymorphs of iso‐tellurazole N‐oxides. These structures are formed by molecules connected by NTe…O chalcogen bonds and are folded in a pattern that defines 89–153 ...
Jin Z. Wang, Phillip MacDougall, Mich W. Zeng, James F. Britten, Ignacio Vargas‐Baca   +4 more
wiley   +1 more source

Turning Bonding Into Function: The Emerging Role of the Bioactive Selenium─Metal Motif in Toxicology and Medicinal Chemistry

Chemistry – A European Journal, EarlyView.
Balancing Act: Se─M bond serving as the fulcrum of the balance scale to compare the different weight of toxicity and therapeutic effects in biological environment. ABSTRACT The synthesis and characterization of organo‐selenium compounds have attracted considerable interest for decades, driven by the search for efficient catalysts and bioinspired ...
Matteo Filippi, Alessandro Rubbi, Pablo A. Nogara, Giovanni Ribaudo, Vito Lippolis, João B. T. Rocha, Laura Orian   +6 more
wiley   +1 more source