Results 11 to 20 of about 3,723 (172)

Chemistry Related to the Catalytic Cycle of the Antioxidant Ebselen

Molecules, 2023
The antioxidant drug ebselen has been widely studied in both laboratories and in clinical trials. The catalytic mechanism by which it destroys hydrogen peroxide via reduction with glutathione or other thiols is complex and has been the subject of ...
Kai N. Sands, Austin L. Burman, Esther Ansah-Asamoah, Thomas G. Back   +3 more
doaj   +3 more sources

Hormetic mechanism of ebselen: A general mechanistic hypothesis

Advances in Redox Research
Ebselen is a small organic molecule developed as a mimetic of the antioxidant enzyme GPx. Ebselen has been extensively studied in cellular models, animals and is now in clinical trials to treat several pathological conditions in which oxidative stress is
Thiago S. Freire, Milena S. Martins, Nadja C. de Souza-Pinto   +2 more
doaj   +2 more sources

Thioredoxin Reductase as a Target for Antibacterial Gold Compounds in Burkholderia cenocepacia: Disclosing the Molecular Basis of Enzyme Inhibition. [PDF]

Chembiochem
The molecular basis of thioredoxin reductase inhibition by antibacterial gold(I) compounds is disclosed. X‐ray crystallography and high‐resolution ESI‐MS reveal selective gold coordination to catalytically relevant cysteine residues of Bc‐TrxR, leading to stable protein–gold adducts and disruption of enzyme redox activity.
Zineddu S, de Azevedo-França JA, Aguanno M, Pecchioli V, Ferraro G, Cuomo V, Merlino A, Messori L.   +7 more
europepmc   +2 more sources

Unraveling the Physicochemical Landscape of Organoselenium Compounds in Nanocarrier Systems. [PDF]

Chem Rec
Main nanocarriers employed to enhance the bioavailability and transport of organoselenium compounds. The image illustrates the key interaction forces that stabilize these organoselenium species in solution, enabling their application in drug delivery systems, catalysis, photoelectronic devices, and sensing technologies. In recent years, publications on
Ramírez RER, Almeida TM, Leite DC, Zeni G.   +3 more
europepmc   +2 more sources

Antibacterial Activity of Ebselen

International Journal of Molecular Sciences, 2023
Ebselen is a low-molecular-weight organoselenium compound that has been broadly studied for its antioxidant, anti-inflammatory, and cytoprotective properties. These advantageous properties were initially associated with mimicking the activity of selenoprotein glutathione peroxidase, but the biomedical impact of this compound appear to be far more ...
Marta Maślanka, Artur Mucha
openaire   +2 more sources

Covalent Modulation of Protein Misfolding and Aggregation Processes in the Context of Neurodegenerative Diseases. [PDF]

Arch Pharm (Weinheim)
This review highlights strengths and pitfalls regarding the covalent inhibitors of misfolded protein aggregation processes in the context of neurodegenerative diseases, with the aim to enhance their potential role as valuable pharmacological tools and prospective therapeutics.
Basagni F, Roggiolani E, Minarini A, Rosini M.   +3 more
europepmc   +2 more sources

Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice

Cell & Bioscience, 2022
Highlights 1. High-throughput screening of ATG4B inhibitors based on FDA-approved drug library 2. Ebselen can covalently bind to ATG4B at Cys74 3. Ebselen can promote ATG4B oligomerization at Cys292 and Cys361 4.
Huazhong Xie, Pengfei Qiang, Yao Wang, Fan Xia, Peiqing Liu, Min Li   +5 more
doaj   +1 more source

Efficacy of Ebselen Against Invasive Aspergillosis in a Murine Model

Frontiers in Cellular and Infection Microbiology, 2021
Invasive aspergillosis is one of the major causes of morbidity and mortality among invasive fungal infections. The search for new antifungal drugs becomes imperative when existing drugs are not able to efficiently treat these infections.
Karina Mayumi Sakita, Isis Regina Grenier Capoci, Pollyanna Cristina Vincenzi Conrado, Franciele Abigail Vilugron Rodrigues-Vendramini, Daniella Renata Faria, Glaucia Sayuri Arita, Tânia Cristina Alexandrino Becker, Patricia de Souza Bonfim-Mendonça, Terezinha Inez Estivalet Svidzinski, Erika Seki Kioshima   +9 more
doaj   +1 more source

Inhibition mechanism of SARS-CoV-2 main protease by ebselen and its derivatives

Nature Communications, 2021
Ebselen is an organoselenium drug that inhibits the SARS-CoV-2 main protease (Mpro). Here, the authors co-crystallised Mpro with ebselen and an ebselen derivative and observed an enzyme bound organoselenium covalent adduct in the crystal structures ...
Kangsa Amporndanai, Xiaoli Meng, Weijuan Shang, Zhenmig Jin, Michael Rogers, Yao Zhao, Zihe Rao, Zhi-Jie Liu, Haitao Yang, Leike Zhang, Paul M. O’Neill, S. Samar Hasnain   +11 more
doaj   +1 more source

Repurposing Clinical Molecule Ebselen to Combat Drug Resistant Pathogens. [PDF]

PLoS ONE, 2015
Without a doubt, our current antimicrobials are losing the battle in the fight against newly-emerged multidrug-resistant pathogens. There is a pressing, unmet need for novel antimicrobials and novel approaches to develop them; however, it is becoming ...
Shankar Thangamani, Waleed Younis, Mohamed N Seleem   +2 more
doaj   +1 more source