Results 21 to 30 of about 3,624 (175)
Cell Reports Medicine, 2020 Summary: Clostridium difficile infection (CDI) is an enteric bacterial disease that is increasing in prevalence worldwide. C. difficile capitalizes on gut inflammation and microbiome dysbiosis to establish infection, with symptoms ranging from watery ...
Megan Garland +7 more
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Ebselen Interferes with Alzheimer’s Disease by Regulating Mitochondrial Function
Antioxidants, 2022 (1) Background: With unknown causes and no effective treatment available, Alzheimer’s disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of ...
Xuexia Li +10 more
doaj +1 more source
Kinetic study of the reaction of ebselen with peroxynitrite [PDF]
FEBS Letters, 1996 The second‐order rate constant for the reaction of ebselen with peroxynitrite (ONOO−) is (2.0±0.1) × 106 M−1s−1 at pH ≥ 8 and 25°C, 3–4 orders of magnitude higher than the rate constants observed for cysteine, ascorbate, or methionine. The activation energy is relatively low, 12.8 kJ/mol.
Hiroshi Masumoto, +3 more
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Repurposing ebselen for decolonization of vancomycin-resistant enterococci (VRE). [PDF]
PLoS ONE, 2018 Enterococci represent one of the microbial world's most challenging enigmas. Colonization of the gastrointestinal tract (GIT) of high-risk/immunocompromised patients by enterococci exhibiting resistance to vancomycin (VRE) can lead to life-threating ...
Ahmed AbdelKhalek +3 more
doaj +1 more source
Convergent Synthesis of Two Fluorescent Ebselen-Coumarin Heterodimers
Pharmaceuticals, 2016 The organo-seleniumdrug ebselen exhibits a wide range of pharmacological effects that are predominantly due to its interference with redox systems catalyzed by seleno enzymes, e.g., glutathione peroxidase and thioredoxin reductase.
Jim Küppers +5 more
doaj +1 more source
The synergistic activity of SBC3 in combination with Ebselen against Escherichia coli infection
Frontiers in Pharmacology, 2022 Escherichia coli ranks as the number one clinical isolate in the past years in China according to The China Antimicrobial Surveillance Network (CHINET), and its multidrug-resistant (MDR) pathogenic strains account for over 160 million cases of dysentery ...
Hao Chen +30 more
doaj +1 more source
Open Medicine, 2023 Iron-overload-associated cardiomyopathy has been one of the primary causes of mortality in thalassemia patients with iron burden. There is growing evidence citing the beneficial effects of ebselen as an antioxidant selectively blocking the divalent metal
Ghazaiean Mobin +3 more
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A Novel Antioxidant Mechanism of Ebselen Involving Ebselen Diselenide, a Substrate of Mammalian Thioredoxin and Thioredoxin Reductase [PDF]
Journal of Biological Chemistry, 2002 The antioxidant mechanism of ebselen involves recently discovered reductions by mammalian thioredoxin reductase (TrxR) and thioredoxin (Trx) forming ebselen selenol. Here we describe a previously unknown reaction; ebselen reacts with its selenol forming an ebselen diselenide with a rate constant of 372 m(-1)s(-1). The diselenide also was a substrate of
Rong, Zhao, Arne, Holmgren
openaire +2 more sources
Advances in Pharmacological and Pharmaceutical Sciences, 2023 Increasing evidence highlights that excessive iron accumulation in the brain plays a vital role in neuronal senescence and is implicated in the pathogenesis of age-related neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s ...
Sirirak Mukem +3 more
doaj +1 more source
Mechanistic Insight into SARS-CoV-2 Mpro Inhibition by Organoselenides: The Ebselen Case Study
Applied Sciences, 2021 The main protease (Mpro) of SARS-CoV-2 is a current target for the inhibition of viral replication. Through a combined Docking and Density Functional Theory (DFT) approach, we investigated in-silico the molecular mechanism by which ebselen (IUPAC: 2 ...
Andrea Madabeni +4 more
doaj +1 more source