Results 1 to 10 of about 3,723 (172)

The Potential Use of Ebselen in Treatment-Resistant Depression

Pharmaceuticals, 2022
Ebselen is an organoselenium compound developed as an antioxidant and subsequently shown to be a glutathione peroxidase (GPx) mimetic. Ebselen shows some efficacy in post-stroke neuroprotection and is currently in trial for the treatment and prevention ...
Philip Cowen, Beata Godlewska, Fitri Fareez Ramli   +2 more
exaly   +6 more sources

Broad-spectrum antiviral activity of ebselen [PDF]

Scientific Reports
Broad-spectrum antivirals are essential for pandemic preparedness, helping reduce mortality and mitigate social disruption. Ebselen, a synthetic organoselenium compound, is under investigation for treating various conditions, including viral infections ...
Kunlakanya Jitobaom, Usa Boonyuen, Chompunuch Boonarkart, Thanyaporn Sirihongthong, Prasert Auewarakul   +4 more
doaj   +4 more sources

Effects of acute ebselen add-on treatment on resting state function connectivity in depressed patients with inadequate response to antidepressants [PDF]

Scientific Reports
Ebselen has been shown to induce a positive emotional processing bias and brain neurochemistry in healthy volunteers. However, little is known about its effects on resting-state functional connectivity (rs-FC) in depressed patients who show inadequate ...
Fitri Fareez Ramli, Luca M. Villa, Marieke A. G. Martens, Nisha Singh, Catherine J. Harmer, Philip J. Cowen, Beata R. Godlewska   +6 more
doaj   +3 more sources

Insights into the complexity of SARS-CoV-2 Mpro inhibition: Ebselen and its derivatives impair dimerisation of the enzyme [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
The SARS-CoV-2 Main Protease (Mpro), a key enzyme for viral replication, represents a highly attractive target for the development of broad-spectrum anti-coronavirus therapeutics.
Simone Fabbian, Silvia Fabi, Laurin Schwarz, Giovanni Preto, Chiara Schiavinato, Cristiano Salata, Letizia Crocetti, Roberto Battistutta, Barbara Gatto, Alice Sosic   +9 more
doaj   +2 more sources

Ebselen Alleviates Sepsis‐Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress, Apoptosis, and Oxidative Stress [PDF]

Veterinary Medicine and Science
Acute kidney injury (AKI) is one of the most serious complications of sepsis, with substantial morbidity and mortality, and no effective treatment exists.
İhsan Karaboğa, Hamza Malik Okuyan, Serdar Doğan, Şeyda Öznur Ayçiçek, Hüseyin Çakıroğlu   +4 more
doaj   +2 more sources

Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Microbiology Spectrum, 2021
Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB by covalently binding to their cysteine protease domains. It was suggested that ebselen lacked antimicrobial activity against Clostridioides difficile.
Ravi K. R. Marreddy, Abiola O. Olaitan, Jordan N. May, Min Dong, Julian G. Hurdle   +4 more
doaj   +1 more source

Ebselen Inhibits the Growth of Lung Cancer Cells via Cell Cycle Arrest and Cell Death Accompanied by Glutathione Depletion

Molecules, 2023
Ebselen is a glutathione (GSH) peroxidase (GPx) mimic originally developed to reduce reactive oxygen species (ROS). However, little is known about its cytotoxicological effects on lung cells.
Woo Hyun Park
doaj   +1 more source

Evaluation of ebselen in resolving a methicillin-resistant Staphylococcus aureus infection of pressure ulcers in obese and diabetic mice.

PLoS ONE, 2021
Pressure ulcers (PUs) are a source of morbidity in individuals with restricted mobility including individuals that are obese or diabetic. Infection of PUs with pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), impairs ulcers from ...
Haroon Mohammad, Nader S Abutaleb, Alexandra M Dieterly, L Tiffany Lyle, Mohamed N Seleem   +4 more
doaj   +1 more source

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

Scientific Reports, 2023
Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (Mpro, 3CLpro) and papain-like protease (PLpro) are responsible for viral polyprotein cleavage—a process crucial for viral survival
Mikolaj Zmudzinski, Wioletta Rut, Kamila Olech, Jarosław Granda, Mirosław Giurg, Małgorzata Burda-Grabowska, Rafał Kaleta, Michala Zgarbova, Renata Kasprzyk, Linlin Zhang, Xinyuanyuan Sun, Zongyang Lv, Digant Nayak, Malgorzata Kesik-Brodacka, Shaun K. Olsen, Jan Weber, Rolf Hilgenfeld, Jacek Jemielity, Marcin Drag   +18 more
doaj   +1 more source

Topical Therapeutic Efficacy of Ebselen Against Multidrug-Resistant Staphylococcus aureus LT-1 Targeting Thioredoxin Reductase

Frontiers in Microbiology, 2020
As a thiol-dependent enzyme, thioredoxin reductase (TrxR) is a promising antibacterial drug target. Ebselen, an organo-selenium with well-characterized toxicology and pharmacology, was recently reported to have potent antibacterial activity against ...
Chuanjiang Dong, Jingxuan Zhou, Peng Wang, Peng Wang, Tao Li, Ying Zhao, Xiaoyuan Ren, Jun Lu, Jun Wang, Jun Wang, Arne Holmgren, Lili Zou   +11 more
doaj   +1 more source