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Broad-spectrum antiviral activity of ebselen [PDF]

Scientific Reports
Broad-spectrum antivirals are essential for pandemic preparedness, helping reduce mortality and mitigate social disruption. Ebselen, a synthetic organoselenium compound, is under investigation for treating various conditions, including viral infections ...
Kunlakanya Jitobaom, Usa Boonyuen, Chompunuch Boonarkart, Thanyaporn Sirihongthong, Prasert Auewarakul   +4 more
doaj   +2 more sources

Ebselen induces reactive oxygen species (ROS)‐mediated cytotoxicity inSaccharomyces cerevisiaewith inhibition of glutamate dehydrogenase being a target

FEBS Open Bio, 2014
Ebselen is a synthetic, lipid-soluble seleno-organic compound. The high electrophilicity of ebselen enables it to react with multiple cysteine residues of various proteins.
Gajendra Kumar Azad, Vikash Singh, Prabhat Singh   +2 more
exaly   +3 more sources

Ebselen Alleviates Sepsis‐Induced Acute Kidney Injury by Regulating Endoplasmic Reticulum Stress, Apoptosis, and Oxidative Stress [PDF]

Veterinary Medicine and Science
Acute kidney injury (AKI) is one of the most serious complications of sepsis, with substantial morbidity and mortality, and no effective treatment exists.
İhsan Karaboğa, Hamza Malik Okuyan, Serdar Doğan, Şeyda Öznur Ayçiçek, Hüseyin Çakıroğlu   +4 more
doaj   +2 more sources

Insights into the complexity of SARS-CoV-2 Mpro inhibition: Ebselen and its derivatives impair dimerisation of the enzyme [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
The SARS-CoV-2 Main Protease (Mpro), a key enzyme for viral replication, represents a highly attractive target for the development of broad-spectrum anti-coronavirus therapeutics.
Simone Fabbian, Silvia Fabi, Laurin Schwarz, Giovanni Preto, Chiara Schiavinato, Cristiano Salata, Letizia Crocetti, Roberto Battistutta, Barbara Gatto, Alice Sosic   +9 more
doaj   +2 more sources

The effect of three urease inhibitors on H. pylori viability, urease activity and urease gene expression [PDF]

Frontiers in Microbiology
BackgroundTreatment of Helicobacter pylori (H. pylori) infections is challenged by antibiotic resistance. The urease enzyme contributes to H. pylori colonization in the gastric acidic environment by producing a neutral microenvironment.
Hanaa Shaalan, Maya Azrad, Avi Peretz, Avi Peretz   +3 more
doaj   +2 more sources

Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing

Microbiology Spectrum, 2021
Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB by covalently binding to their cysteine protease domains. It was suggested that ebselen lacked antimicrobial activity against Clostridioides difficile.
Ravi K. R. Marreddy, Abiola O. Olaitan, Jordan N. May, Min Dong, Julian G. Hurdle   +4 more
doaj   +1 more source

Ebselen Inhibits the Growth of Lung Cancer Cells via Cell Cycle Arrest and Cell Death Accompanied by Glutathione Depletion

Molecules, 2023
Ebselen is a glutathione (GSH) peroxidase (GPx) mimic originally developed to reduce reactive oxygen species (ROS). However, little is known about its cytotoxicological effects on lung cells.
Woo Hyun Park
doaj   +1 more source

The Potential Use of Ebselen in Treatment-Resistant Depression

Pharmaceuticals, 2022
Ebselen is an organoselenium compound developed as an antioxidant and subsequently shown to be a glutathione peroxidase (GPx) mimetic. Ebselen shows some efficacy in post-stroke neuroprotection and is currently in trial for the treatment and prevention ...
Fitri Fareez Ramli, Philip J. Cowen, Beata R. Godlewska   +2 more
doaj   +1 more source

Evaluation of ebselen in resolving a methicillin-resistant Staphylococcus aureus infection of pressure ulcers in obese and diabetic mice.

PLoS ONE, 2021
Pressure ulcers (PUs) are a source of morbidity in individuals with restricted mobility including individuals that are obese or diabetic. Infection of PUs with pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), impairs ulcers from ...
Haroon Mohammad, Nader S Abutaleb, Alexandra M Dieterly, L Tiffany Lyle, Mohamed N Seleem   +4 more
doaj   +1 more source

Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase

Scientific Reports, 2023
Proteases encoded by SARS-CoV-2 constitute a promising target for new therapies against COVID-19. SARS-CoV-2 main protease (Mpro, 3CLpro) and papain-like protease (PLpro) are responsible for viral polyprotein cleavage—a process crucial for viral survival
Mikolaj Zmudzinski, Wioletta Rut, Kamila Olech, Jarosław Granda, Mirosław Giurg, Małgorzata Burda-Grabowska, Rafał Kaleta, Michala Zgarbova, Renata Kasprzyk, Linlin Zhang, Xinyuanyuan Sun, Zongyang Lv, Digant Nayak, Malgorzata Kesik-Brodacka, Shaun K. Olsen, Jan Weber, Rolf Hilgenfeld, Jacek Jemielity, Marcin Drag   +18 more
doaj   +1 more source