Results 131 to 140 of about 119,488 (298)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Elliptic flow, eccentricity and eccentricity fluctuations

, 2007
Differential studies of elliptic flow are one of the most powerful tools in studying the initial conditions and dynamical evolution of heavy ion collisions. The comparison of data from Cu+Cu and Au+Au collisions taken with the PHOBOS experiment at RHIC provides new information on the interplay between initial geometry and initial particle density in ...
Loizides, Constantin, Alver, B., Back, B.B., Baker, M.D., Ballintijn, M., Barton, D.S., Betts, R.R., Bindel, R., Busza, W., Chai, Z., Chetluru, V., García, E., Gburek, T., Gulbrandsen, K., Hamblen, J., Harnarine, I., Henderson, C., Hofman, D.J., Hollis, R.S., Holynski, R., Holzman, B., Iordanova, A., Kane, J.L., Kulinich, P., Kuo, C.M., Li, W., Lin, W.T., Manly, S., Mignerey, A.C., Nouicer, R., Olszewski, A., Pak, R., Reed, C., Richardson, E., Roland, C., Roland, G., Sagerer, J., Sedykh, I., Smith, C.E., Stankiewicz, M.A., Steinberg, P., Stephans, G.S.F., Sukhanov, A., Szostak, A., Tonjes, M.B., Trzupek, A., van Nieuwenhuizen, G.J., Vaurynovich, S.S., Verdier, R., Veres, G.I., Walters, P., Wenger, E., Willhelm, D., Wolfs, F.L.H., Wosiek, B., Wozniak, K., Wyngaardt, S., Wyslouch, B.   +57 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Effects of Lift Velocity on Muscle Activation During Leg Extension [PDF]

, 2013
It is not known if manipulating velocity within a prescribed resistance training mode will improve muscle activation. Muscle activations of the Rectus Femoris (RF), Vastus Lateralis (VL), Vastus Medialis (VM) and Bicep Femoris (BF) were examined during a
Johnson, Scott, Hatzel, Brian, Glass, Stephen C., Sjoquist, Heather   +3 more
core  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Eccentric Exercise as a Training Modality: A Brief Review

, 2015
An eccentric muscle action involves the lengthening of a muscle due to an external load and occurs as a result of the mechanical disruption of action and myosin.
Bridgeman, L, Gill, N, McGuigan, M
core   +1 more source