Results 141 to 150 of about 119,488 (298)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Early Post-TAVI Physical Activity After Eccentric Training Compared to Standard Practice – Results of a Feasibility Study

Clinical Interventions in Aging
Anja Haase-Fielitz,1– 3 Josefine Stoll,4 Tilman Engel,4 Claudia Beckendorf,4 Michael Haase,5– 7 Tanja Kücken,1,2 Michael Neuß,1,2 Christian Butter1,2 1Department of Cardiology, University Hospital Heart Centre Brandenburg, Brandenburg Medical School (MHB)
Haase-Fielitz A, Stoll J, Engel T, Beckendorf C, Haase M, Kücken T, Neuß M, Butter C   +7 more
doaj  

ACOUSTIC STUDY OF NIGHTTIME DELIVERIES IN STOCKHOLM WITHIN THE PROJECT CIVITAS ECCENTRIC

, 2020
The present contribution reports part of the study conducted in the context of the CIVITAS ECCENTRIC European project, focused on the investigation of the conditions for silent deliveries in the city of Stockholm, Sweden.In particular, the methodology ...
Venkataraman, Siddharth,, Rumpler, Romain,   +1 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Examining the Impact of Supramaximal Eccentric and Long-Lever Isometric Training Protocols on Isometric Hamstring Strength, Nordic Hamstring Performance, and Sprint Speed. [PDF]

Eur J Sport Sci
Sundh AE, VerVoort DS, Ripley NJ, Lamb AJ, Comfort P.   +4 more
europepmc   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Hamstring Injury Mechanisms and Eccentric Training-Induced Muscle Adaptations: Current Insights and Future Directions

Hamstring injuries are a major concern in sports owing to their high incidence and recurrence rates, highlighting the need for a deeper understanding of their mechanisms and prevention.
Shield, Anthony J., Andrews, Max H., Pincheira, Patricio A., Lichtwark, Glen A.   +3 more
core   +1 more source