Results 221 to 230 of about 2,318,785 (281)

New ecdysone receptor agonists: a computational approach for rational discovery of insecticides for crop protection

Molecular Systems Design & Engineering, 2021
Plant derived (C. deodara) in-house synthesized molecules with benzosuberene scaffolds as potential EcR agonists to target Hemiptera and Coleoptera.
Rahul Singh, Vijay Kumar Bhardwaj, P. Das, Rituraj Purohit   +3 more
semanticscholar   +1 more source

Steered molecular dynamics for studying ligand unbinding of ecdysone receptor

Journal of Biomolecular Structure and Dynamics, 2018
Ecdysone receptor (EcR) is an important target for pesticide design. Ligand binding regulates EcR transcriptional activity similar to other nuclear receptors; however, the pathways by which ligands enter and leave the EcR remain poorly understood.
Xueping Hu, Song Hu, Jiazhe Wang, Yawen Dong, Li Zhang, Yanhong Dong   +5 more
semanticscholar   +3 more sources

Ecdysone receptors and their biological actions

2000
Publisher Summary This chapter discusses the ecdysone receptors and their biological actions. It also summarizes the insect endocrinology and the roles of these steroids in the molting and metamorphosis. Natural hormones that lead to molting and metamorphosis are ecdysones.
L M, Riddiford, P, Cherbas, J W, Truman
openaire   +2 more sources

Ligand‐Binding Pocket of the Ecdysone Receptor

2005
The ecdysone receptor (EcR) belongs to the superfamily of nuclear receptors (NRs) that are ligand-dependent transcription factors. Ecdysone receptor is present only in invertebrates and plays a central role in regulating the expression of a vast array of genes during development and reproduction.
Isabelle M L, Billas, Dino, Moras
openaire   +2 more sources

RNA interference targeting ecdysone receptor blocks the larval–pupal transition in Henosepilachna vigintioctopunctata

Insect Science, 2020
Henosepilachna vigintioctopunctata is a serious insect pest which attacks a large number of nightshades and cucurbits in Asian countries, Brazil and Australia. Prolonged application of traditional pesticides has caused environmental pollution and exerted
Jian-Jian Wu, Li-li Mu, Wei-Nan Kang, Long-Ji Ze, Chen-Hui Shen, Lin Jin, A. A. Anjum, Guo-Qing Li   +7 more
semanticscholar   +1 more source

Ligand binding by recombinant domains from insect ecdysone receptors

Insect Biochemistry and Molecular Biology, 2007
The ligand binding domains (LBDs) from the EcR and USP proteins of four insect pests (Lucilia cuprina, Myzus persicae, Bemisia tabaci, Helicoverpa armigera) were purified as recombinant heterodimers. The K(d) values for [(3)H]-ponasterone A binding by LBD heterodimers that included the hinge regions (i.e., DE/F heterodimers) ranged 0.7-2.5 nM, with K(i)
L D, Graham, W M, Johnson, A, Pawlak-Skrzecz, R E, Eaton, M, Bliese, L, Howell, G N, Hannan, R J, Hill   +7 more
openaire   +2 more sources

Molecular characterization and functional analysis of the ecdysone receptor isoform (EcR) from the oriental fruit moth Grapholita molesta (Lepidoptera: Tortricidae).

Archives of Insect Biochemistry and Physiology
20-Hydroxyecdysone (20E) plays a vital role in a series of biological processes, via the nuclear receptors, EcR/USP by activating the ecdysone regulatory cascade.
Zhishan Cao, O. Bakumenko, Volodymyr Vlasenko, Weihai Li, Jinjun Cao   +4 more
semanticscholar   +1 more source

Ecdysone Receptors: From the Ashburner Model to Structural Biology

Annual Review of Entomology, 2013
In 1974, Ashburner and colleagues postulated a model to explain the control of the puffing sequence on Drosophila polytene chromosomes initiated by the molting hormone 20-hydroxyecdysone. This model inspired a generation of molecular biologists to clone and characterize elements of the model, thereby providing insights into the control of gene ...
Hill, Ronald J., Billas, Isabelle M. L., Bonneton, François, Graham, Lloyd D., Lawrence, Michael C.   +4 more
openaire   +3 more sources

Ecdysone receptor expression and activity in adult Drosophila melanogaster

Journal of Insect Physiology, 2011
Disrupting components of the ecdysone/EcR/USP signaling pathway in insects leads to morphological defects and developmental arrest. In adult Drosophila melanogaster decreased EcR function affects fertility, lifespan, behavior, learning, and memory; however we lack a clear understanding of how EcR/USP expression and activity impacts these phenotypes. To
Christoph, Schwedes, Siddharth, Tulsiani, Ginger E, Carney   +2 more
openaire   +2 more sources

Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation

Cell, 1992
The vertebrate retinoid X receptor (RXR) has been implicated in the regulation of multiple hormonal signaling pathways through the formation of heteromeric receptor complexes that bind DNA with high affinity. We now demonstrate that ultraspiracle (usp), a Drosophila RXR homolog, can substitute for RXR in stimulating the DNA binding of receptors for ...
T P, Yao, W A, Segraves, A E, Oro, M, McKeown, R M, Evans   +4 more
openaire   +2 more sources