Results 231 to 240 of about 2,318,785 (281)

Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle

Nature, 1993
Ecdysone in Drosophila has been a paradigm for steroid hormones since its ability to induce gene activity directly was demonstrated by its effects on moulting and polytene chromosome puffing. The ecdysone receptor (EcR) was recently confirmed as a member of the nuclear receptor superfamily by cloning and characterization in a Drosophila cell line. Here
H E, Thomas, H G, Stunnenberg, A F, Stewart   +2 more
openaire   +2 more sources

Identification of 1‐phenyl‐4‐cyano‐5‐aminopyrazoles as novel ecdysone receptor ligands by virtual screening, structural optimization, and biological evaluations

Chemical Biology and Drug Design, 2020
Ecdysteroids initiate the molting process in insects by binding to the ecdysone receptor (EcR), which is a promising target for identifying insect growth regulators.
Xueping Hu, Xiaojuan Ma, Jialin Cui, Haishan Liu, Bin Zhu, Jingran Xie, P. Liang, Li Zhang   +7 more
semanticscholar   +1 more source

Comparative toxicity and ecdysone receptor affinity of non-steroidal ecdysone agonists and 20-hydroxyecdysone in Chironomus tentans

Insect Biochemistry and Molecular Biology, 2002
Ecdysone agonists belonging to the bisacylhydrazine class of compounds are a new generation of insecticidal compounds that cause premature lethal molts in susceptible intoxicated insects. While two of the bisacylhydrazines (coded as RH-5992 and RH-2485) are predominantly toxic to lepidopteran pests, RH-5849, which has not been commercialized, has a ...
Smagghe, Guy, Dhadialla, T., Lezzi, Markus   +2 more
openaire   +3 more sources

Nuclear localization and DNA binding of ecdysone receptor and ultraspiracle

Archives of Insect Biochemistry and Physiology, 2007
AbstractThe Ecdysone receptor (EcR) is distributed between cytoplasm and nucleus in CHO cells. Nuclear localization is increased by the ligand Muristerone A. The most important heterodimerization partner Ultraspiracle (Usp) is localized predominantly in the nucleus.
M V, Cronauer, S, Braun, Ch, Tremmel, K-D, Kröncke, M, Spindler-Barth   +4 more
openaire   +2 more sources

Drosophila ecdysone receptor functions as a constitutive activator in yeast

The Journal of Steroid Biochemistry and Molecular Biology, 1997
Transcriptional activation of the Drosophila ecdysone receptor (EcR) was studied in yeast cells, which carry a reporter plasmid containing the ecdysone response element in the absence or presence of its heterodimeric partners, ultraspiracle protein (USP) or human retinoid X receptor (RXRalpha).
F, Dela Cruz, P, Mak
openaire   +2 more sources

Molecular cloning, characterization and expression analysis of the ecdysone receptor from the spiny lobster Panulirus homarus (Linnaeus, 1758) (Decapoda, Palinuridae)

, 2020
The ecdysone receptor (EcR) is a crucial nuclear transcription factor that participates in ecdysteroid signalling. In this study, cDNA of EcR in Panulirus homarus (Linnaeus, 1758) (PhEcR) was cloned and characterized.
Hongbiao Zhuo, Huafang Liang, Cai X. Cai, Jia J. Luo, F. Liang, C. Wen   +5 more
semanticscholar   +1 more source

Increased Male–Male Courtship in Ecdysone Receptor Deficient Adult Flies

Behavior Genetics, 2007
Male-male courtship is infrequent among mature adult Drosophila melanogaster. After pairs of mature adult males expressing a temperature-sensitive allele of the ecdysone receptor (EcR) gene were treated at a restrictive temperature, however, they engaged in elevated levels of male-male courtship.
Geoffrey K, Ganter, Kelsey L, Walton, Jacob O, Merriman, Mark V, Salmon, Krista M, Brooks, Swathi, Maddula, Edward A, Kravitz   +6 more
openaire   +2 more sources

Chemical-Inducible, Ecdysone Receptor-Based Gene Expression System for Plants

Transgenic Research, 2003
We have developed an inducible gene expression system with potential for field application using the ecdysone receptor (EcR) from the spruce budworm and the non-steroidal EcR agonist, methoxyfenozide. Chimeric transcription activators were constructed with EcR ligand binding domain, GAL4 and LexA DNA binding domains, and VP16 activation domain.
Malla, Padidam, Michael, Gore, D Lily, Lu, Olga, Smirnova   +3 more
openaire   +2 more sources

Multidomain sumoylation of the ecdysone receptor (EcR) from Drosophila melanogaster

The Journal of Steroid Biochemistry and Molecular Biology, 2013
The 20-hydroxyecdysone receptor (EcR) is a transcription factor belonging to the nuclear receptor superfamily. Together with the ultraspiracle nuclear receptor (Usp) it coordinates critical biological processes in insects such as development and reproduction.
Justyna, Seliga, Katarzyna, Bielska, Elżbieta, Wieczorek, Marek, Orłowski, Rainer, Niedenthal, Andrzej, Ożyhar   +5 more
openaire   +2 more sources

Coordination of Drosophila Metamorphosis by Two Ecdysone-Induced Nuclear Receptors

Science, 1997
The functions of the ecdysone-induced DHR3 and E75B orphan nuclear receptors in the early stages of Drosophila metamorphosis were investigated. DHR3 represses the ecdysone induction of early genes turned on by the pulse of ecdysone that triggers metamorphosis.
K P, White, P, Hurban, T, Watanabe, D S, Hogness   +3 more
openaire   +2 more sources