Results 31 to 40 of about 2,318,785 (281)

Plasticity of the Ecdysone Receptor DNA Binding Domain [PDF]

open access: bronzeMolecular Endocrinology, 2004
Ecdysteroids coordinate molting and metamorphosis in insects via a heterodimer of two nuclear receptors, the ecdysone receptor (EcR) and the ultraspiracle (Usp) protein. Here we show how the DNA-recognition alpha-helix and the T box region of the EcR DNA-binding domain (EcRDBD) contribute to the specific interaction with the natural response element ...
Marek Orłowski   +10 more
openalex   +3 more sources

The nuclear receptors of Biomphalaria glabrata and Lottia gigantea: Implications for developing new model organisms [PDF]

open access: yes, 2015
© 2015 Kaur et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Antebi   +131 more
core   +10 more sources

Improved ecdysone receptor‐based inducible gene regulation system [PDF]

open access: yesEuropean Journal of Biochemistry, 2003
To develop an ecdysone receptor (EcR)‐based inducible gene regulation system, several constructs were prepared by fusing DEF domains of Choristoneura fumiferana EcR (CfEcR), C. fumiferana ultraspiracle (CfUSP), Mus musculus retinoid X receptor (MmRXR) to either GAL4 DNA binding domain (DBD) or VP16 activation domain.
Subba R, Palli   +3 more
openaire   +4 more sources

Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2016
BACKGROUND:A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic ...
Amruta S Mhashilkar   +8 more
doaj   +1 more source

Larval diapause termination in the bamboo borer, Omphisa fuscidentalis. [PDF]

open access: yesPLoS ONE, 2017
In insects, juvenile hormone (JH) and 20-hydroxyecdysone (20E) regulate larval growth and molting. However, little is known about how this cooperative control is terminating larval diapause especially in the bamboo borer, Omphisa fuscidentalis.
Suphawan Suang   +7 more
doaj   +1 more source

The ecdysone receptor promotes or suppresses proliferation according to ligand level

open access: yesbioRxiv, 2023
Steroid hormones control various cellular activities in a context-dependent manner. For example, ecdysone, which acts through a type II nuclear receptor, has seemingly opposite effects in Drosophila wing precursors, promoting proliferation during larval ...
Gantas Perez-Mockus   +5 more
semanticscholar   +1 more source

Molecular evidence for a functional ecdysone signaling system in Brugia malayi. [PDF]

open access: yesPLoS Neglected Tropical Diseases, 2010
BACKGROUND:Filarial nematodes, including Brugia malayi, the causative agent of lymphatic filariasis, undergo molting in both arthropod and mammalian hosts to complete their life cycles.
George Tzertzinis   +7 more
doaj   +1 more source

Home - About - Disclaimer - Privacy