Sources of Environmental Exposure to the Naturally Occurring Anabolic Steroid Ecdysterone in Horses [PDF]
AnimalsEcdysterone controls moulting and reproduction in insects, crustaceans, and helminths. It is also produced by many plants, probably as an insect deterrent. The steroid is not made by vertebrates but has anabolic effects in mammals and could be useful for
Martin N. Sillence +5 more
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Regulation of osteoblast autophagy based on PI3K/AKT/mTOR signaling pathway study on the effect of β-ecdysterone on fracture healing [PDF]
Journal of Orthopaedic Surgery and Research, 2021 Objectives To investigate the effects of β-ecdysterone on fracture healing and the underlying mechanism. Methods MTT assay was used to detect the cell viability. AO/PI and flow cytometry assays were used to determine the apoptotic rate.
Yanghua Tang +6 more
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Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? [PDF]
CellsThe 20-hydroxyecdysone (20E) has been used in traditional medicine for a long time and acquired attention in the last decade as a food supplement and stimulant in physical activities.
Ernő Zádor
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How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study [PDF]
Journal of the International Society of Sports NutritionIntroduction Phytosteroids like 20-hydroxyecdysone (20E) and diosgenin (DSG) have shown promising anabolic and performance-enhancing effects in in vitro, animal, and human studies.
Joshua Dissemond +8 more
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Ecdysterone Alleviates Atherosclerosis by Inhibiting NCF2 and Inhibiting Ferroptosis Mediated by the PI3K/Akt/Nrf2 Pathway [PDF]
Journal of Cellular and Molecular Medicine, Volume 29, Issue 5, March 2025.ABSTRACT Ecdysterone (Ecd), an active ingredient in trianthema, has a strong anti‐inflammatory effect. This study aimed to explore the potential mechanism by which Ecd improves atherosclerosis (AS). Here, we systematically investigated the mechanism of Ecd in human umbilical vein endothelial cells (HUVECs) treated with oxidised low‐density lipoprotein (
Zhenyu Wang +7 more
wiley +2 more sources
Phytochemical synergies in BK002: advanced molecular docking insights for targeted prostate cancer therapy [PDF]
Frontiers in PharmacologyAchyranthes japonica (Miq.) Nakai (AJN) and Melandrium firmum (Siebold and Zucc.) Rohrb. (MFR) are medicinal plants recognized for their bioactive phytochemicals, including ecdysteroids, anthraquinones, and flavonoids.
Moon Nyeo Park +11 more
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Eyestalk transcriptome analysis reveals sexually dimorphic host-parasite interactions: divergent molecular strategies of Polyascus sp. for reproductive and growth regulation in Eriocheir sinensis [PDF]
PeerJBackground The Chinese mitten crab (Eriocheir sinensis), an economically critical migratory species inhabiting both freshwater and marine environments, is susceptible to parasitization by the rhizocephalan barnacle Polyascus sp.
Jing Xie +4 more
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Genetic Evidence Prioritizes Neurocognitive Decline as a Causal Driver of Sleep Disturbances: A Multi-Omics Analysis Identifying Causal Genes and Therapeutic Targets [PDF]
Current Issues in Molecular BiologyTo resolve the ambiguous causal relationship between sleep disturbances and neurodegenerative diseases such as Alzheimer’s disease (AD), we conducted a multi-stage genetic and multi-omics investigation.
Yanan Du +8 more
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Effects of Dietary Supplementation Using Phytobiotics with Different Functional Properties on Expression of Immunity Genes, Intestinal Histology, Growth, and Meat Productivity of Broiler Chickens [PDF]
Veterinary SciencesThe aim of this study was to investigate the expression of immunity-related genes and morpho-histological features of the intestines, and the growth and meat production of broiler chickens when fed plant extracts with different functional components ...
Marina I. Selionova +4 more
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Simultaneous Determination of Fourteen Marker Compounds in the Traditional Herbal Prescription, Geumgwesingihwan, Using Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry [PDF]
Molecules, 2022 Geumgwesingihwan (GSH) is a traditional herbal prescription composed of eight medicinal herbs: Rehmannia glutinosa (Gaertn.) DC., Dioscorea japonica Thunb., Cornus officinalis Siebold and Zucc., Poria cocos Wolf, Paeonia suffruticosa Andrews, Alisma ...
Chang-Seob Seo, Mee-Young Lee
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