Results 51 to 60 of about 144 (134)

Mechanism of Jianpixiaoke Recipe in Treating Type 2 Diabetes Based on Network Pharmacology and Molecular Docking

open access: yesInternational Journal of Endocrinology, Volume 2025, Issue 1, 2025.
Objective Using network pharmacology and molecular docking technology to analyze the potential mechanism of the Jianpixiaoke recipe (JPXK recipe) in the treatment of type 2 diabetes mellitus (T2DM). Method This study searched and screened the active ingredients and corresponding T2DM‐related targets of different herbs in JPXK recipe from multiple ...
Huan Li   +5 more
wiley   +1 more source

Qi‐Gui‐Sheng‐Jiang‐San Decoction Regulating Hypoxia Response Through Non–Oxygen‐Dependent Pathway Improves Diabetic Kidney Disease: Coupling Network Pharmacology With Experimental Verification

open access: yesJournal of Diabetes Research, Volume 2025, Issue 1, 2025.
Background Diabetic kidney disease (DKD) is a major global cause of end‐stage renal disease. Emerging evidence suggests that hypoxia is a critical factor in the advancement of DKD. Traditional Chinese medicine (TCM) is an effective alternative therapy for DKD.
Yi-fan Liu   +11 more
wiley   +1 more source

Quality control method for Yao medicine Hongniuxi

open access: yesGuangxi Zhiwu
Yao medicine Hongniuxi is the root and rhizome of Achyranthes longifolia, which is a commonly used medicinal herb in Yao ethnic areas. Currently, only a few provinces and regions have recorded the method for quality control of Hongniuxi.
CHEN Song   +4 more
doaj   +1 more source

Immunomodulatory Mechanisms of Rehmanniae Radix Praeparata–Achyranthes Root–Chinese Angelica Root Combination in Nontraumatic Osteonecrosis of the Femoral Head: A Comprehensive Network Pharmacology and Molecular Docking Study Focusing on Immunological Pathways

open access: yesMediators of Inflammation, Volume 2025, Issue 1, 2025.
Objective Nontraumatic osteonecrosis of the femoral head (NONFH) is a devastating condition characterised by immune dysregulation and sterile inflammation, which are increasingly acknowledged as central pathogenic mechanisms. This study aims to identify the core herbal combination for NONFH and systematically explore its immunomodulatory effects and ...
Xin Li   +10 more
wiley   +1 more source

Stimulation of Protein Synthesis in Mouse Liver by Ecdysterone

open access: yesChemical and Pharmaceutical Bulletin, 1969
The effect of insect-moulting steroid, ecdysterone, on protein synthesis in mouse liver was studied. The administration of ecdysterone caused an early stimulation of protein synthesis, as indicated by the marked increase in the incorporation of 14C-chlorella hydrolysate into hot-acid insoluble protein, as early as 2 hr after the treatment as well as ...
OTAKA, TADAHIKO   +2 more
openaire   +3 more sources

Phytochemical Analysis and Anti‐inflammatory Potential of Floscopa Scandens Lour. and Exploring Ecdysterone as Promising Therapeutic Agent: An HR‐LCMS Screening and Molecular Docking Analysis

open access: yesChemistrySelect, Volume 9, Issue 40, October 25, 2024.
This study analyzed the bioactive compounds of Floscopa scandens Lour. using HR‐LCMS, isolating 21 phytoconstituents, including ecdysterone as the prominent. Molecular docking and molecular dynamic simulations revealed ecdysterone's anti‐inflammatory potential, confirming its therapeutic significance.
Sailaja Nambaaru   +5 more
wiley   +1 more source

Quinoa as phytopharmaceutical? Urinary elimination of ecdysterone after consumption of quinoa alone and in combination with spinach

open access: yesArchiv der Pharmazie, Volume 357, Issue 6, June 2024.
The phytosteroid ecdysterone and its metabolites were detected in reasonable amounts in humans after ingestion of quinoa. Future potential of therapeutical applications should be investigated. Abstract The phytosteroid ecdysterone is classified as an anabolic agent and has been included on the monitoring list of the World Anti‐Doping Agency since 2020.
Eduard Isenmann   +7 more
wiley   +1 more source

Annual banned‐substance review 16th edition—Analytical approaches in human sports drug testing 2022/2023

open access: yesDrug Testing and Analysis, Volume 16, Issue 1, Page 5-29, January 2024.
Abstract In this 16th edition of the annual banned‐substance review on analytical approaches in human sports drug testing, literature on recent developments in this particular section of global anti‐doping efforts that was published between October 2022 and September 2023 is summarized and discussed.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study

open access: yesJournal of the International Society of Sports Nutrition
Introduction Phytosteroids like 20-hydroxyecdysone (20E) and diosgenin (DSG) have shown promising anabolic and performance-enhancing effects in in vitro, animal, and human studies.
Joshua Dissemond   +8 more
doaj   +1 more source

Phytochemical synergies in BK002: advanced molecular docking insights for targeted prostate cancer therapy

open access: yesFrontiers in Pharmacology
Achyranthes japonica (Miq.) Nakai (AJN) and Melandrium firmum (Siebold and Zucc.) Rohrb. (MFR) are medicinal plants recognized for their bioactive phytochemicals, including ecdysteroids, anthraquinones, and flavonoids.
Moon Nyeo Park   +11 more
doaj   +1 more source

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