Results 1 to 10 of about 1,564 (197)

Echinacoside Ameliorates UVB-Induced Skin Damage Through Selective Inhibition of the Cutaneous TRPV3 Channel [PDF]

Molecules
Excessive exposure to ultraviolet B (UVB) radiation can lead to skin damage, such as erythema and swelling. Echinacoside is a key effective ingredient of medicinal plant Cistanche deserticola commonly used for therapies and treatments for anti-aging and ...
Shilun Mo, Xinying Yue, Yaxuan Qu, Guoji Zhang, Liqin Wang, Xiaoying Sun   +5 more
doaj   +3 more sources

Optimization of Fermentation Condition for Echinacoside Yield Improvement with Penicillium sp. H1, an Endophytic Fungus Isolated from Ligustrum lucidum Ait Using Response Surface Methodology

Molecules, 2018
(1) Background: Application of echinacoside has become increasingly important for its significant biological activities. However, there are many disadvantages in existing synthesis methods such as contaminating the environment, harsh reaction conditions ...
Hui Cao, Hong Guo, Xiaowei Cui
exaly   +4 more sources

Echinacoside ameliorates hepatic fibrosis and tumor invasion in rats with thioacetamide-induced hepatocellular carcinoma [PDF]

Biomolecules & Biomedicine
Hepatocellular carcinoma (HCC) affects approximately 800,000 individuals globally each year. Despite advancements in HCC treatments, there is still a pressing need to identify new drugs that can combat resistance. One potential option is echinacoside, a
Ajwan Z Albalawi, Areej S Alatawi, Shekha M Al-Atwi, Lama S Alhwyty, Kadi M Alharbi, Shahad A Alshehri, Wasayf A Almarwani, Khulud K Aljohani, Hanan M Hassan, Mohammed M H Al-Gayyar   +9 more
doaj   +4 more sources

Echinacoside prevents hypoxic pulmonary hypertension by regulating the pulmonary artery function

Journal of Pharmacological Sciences, 2020
Hypoxic pulmonary hypertension (HPH) is a progressive and irreversible disease that reduces survival. Echinacoside is a phenylethanoid glycoside from Tibetan herbs known for its vasorelaxant effect and for inhibiting the proliferation of rat pulmonary ...
Dianxiang Lu, Zhan-Qiang Li, Pengcheng Lin   +2 more
exaly   +5 more sources

Echinacoside Improves Pulmonary Vascular Remodeling by Regulating the L‐ and T‐Type Ca2+ Channels in the Prevention and Treatment of Pulmonary Hypertension [PDF]

Pulmonary Circulation
The typical pathology of pulmonary hypertension (PH) is characterized by pulmonary vasoconstriction and irreversible pulmonary vascular remodeling. Vascular remodeling is the process of structural changes and cellular rearrangement of blood vessels due ...
Yuefu Zhao, Jinyu Wang, Yujie Qiao, Xiangyun Gai, Jiacheng Hu, Hongmai Wang, Qingqing Xia, Qiuqin Hu, Zhanqiang Li, Cen Li, Hongtao Bi   +10 more
doaj   +3 more sources

Echinacoside Alleviates Cisplatin-Induced Acute Kidney Injury by Regulating Bap1 to Inhibit Ferroptosis [PDF]

Biomedicines
Background/Objectives: Cisplatin-induced acute kidney injury (AKI) is a major adverse complication restricting cisplatin-based chemotherapy. Ferroptosis contributes substantially to proximal tubular epithelial injury during AKI.
Lijia Chen, Mingjie Zhang, Miao Chi, Zehua Ye, Bojun Li, Songyuan Yang, Miao Zhang, Wei Dong, Haoyong Li, Xiangjun Zhou   +9 more
doaj   +2 more sources

Study on Echinacoside-Copper Metal–Phenolic Networks Hydrogel System Loaded with Diallyl Trisulfide for Local Treatment of Cervical Cancer [PDF]

Pharmaceutics
Background/Objectives: Cervical cancer cells evade chemotherapy by upregulating antioxidant defenses (e.g., glutathione (GSH)). A platform that simultaneously amplifies ROS and suppresses antioxidant defense is a low toxicity strategy.
Na Zhao, Xiaoqian Zhang, Jing Luo, Xiaoyue Zhang, Yonghong Zhao, Jiang Liu, Le Li, Chenglin Hong, Shiguo Sun   +8 more
doaj   +2 more sources

Total Phenylethanoid Glycosides from Cistanche tubulosa Alleviate 5-Fluorouracil-Induced Fatigue-Like Behavior and Skeletal Muscle Injury in Mice [PDF]

Biomedicines
Objectives: This study investigated the effects of total phenylethanoid glycosides from Cistanche tubulosa (CPhGs) on 5-fluorouracil (5-FU)-induced fatigue-like behavior and tissue injury in mice and examined associated molecular changes. Methods: Public
Jinjin Chen, Jianhua Yang, Yexia Cao, Limei Wen, Xufeng Su, Jiayuan Yan, Qiang Hou, Shilei Zhang, Junping Hu   +8 more
doaj   +2 more sources

Echinacoside reduces intracellular c-di-GMP levels and potentiates tobramycin activity against Pseudomonas aeruginosa biofilm aggregates [PDF]

npj Biofilms and Microbiomes
Cyclic diguanylate (c-di-GMP) is a central biofilm regulator in Pseudomonas aeruginosa, where increased intracellular levels promote biofilm formation and antibiotic tolerance.
Yu-Ming Cai, Feng Hong, Amber De Craemer, Jacob George Malone, Aurélie Crabbé, Tom Coenye   +5 more
doaj   +2 more sources

Echinacoside exerts antidepressant-like effects through enhancing BDNF-CREB pathway and inhibiting neuroinflammation via regulating microglia M1/M2 polarization and JAK1/STAT3 pathway

Frontiers in Pharmacology, 2023
The present study was performed to investigate the antidepressant effect of echinacoside (ECH) using chronic unpredictable mild stress (CUMS) induced depression mice and lipopolysaccharide (LPS)-stimulated N9 microglial cells.
Renrui Lu, Li Zhang, Li Zhang, Huihui Wang, Meng Li, Meng Li, Weisheng Feng, Weisheng Feng, Xiaoke Zheng, Xiaoke Zheng   +9 more
doaj   +1 more source