Results 11 to 20 of about 9,178 (186)

Overcoming Electrochemiluminescence Immunoassay (ECLIA) Limitations: Conformation-Independent Quantitation of a Therapeutic Antibody by LC–MS/MS [PDF]

Analytical Chemistry
Abstract Monoclonal antibody therapies have transformed cancer treatment by enabling targeted intervention even in advanced disease stages. However, reliable monitoring of circulating therapeutic antibody levels is critical to ensuring efficacy and patient safety.
Claudia Gaither, Robert Popp, Pradyumn Maheshwari, Mauricio Lemus, Julie Laurin, Mario Filion, Christoph H. Borchers   +6 more
europepmc   +4 more sources

Serum Neurofilament Light Chain and GFAP in Amyotrophic Lateral Sclerosis on a Commercial ECLIA Platform [PDF]

Muscle & Nerve
ABSTRACT Introduction/Aims In amyotrophic lateral sclerosis (ALS), SIMOA‐based studies show that baseline serum neurofilament light chain (NfL) predicts the revised ALS Functional Rating Scale (ALSFRS‐R) decline rate and survival.
Streicher NS.
europepmc   +4 more sources

Blood-Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications. [PDF]

Aging Med (Milton)
Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Li S, Huang L, Guo Q.
europepmc   +2 more sources

Comparative Analytical Performance and Clinical Agreement of Chemiluminescence Microparticle Immunoassay and Electrochemiluminescence Immunoassay for CA19-9: A Diagnostic Accuracy Study [PDF]

Diagnostics
Background: Carbohydrate antigen 19-9 (CA19-9) is widely used as a tumor marker for pancreatic and hepatobiliary malignancies. However, inter-assay variability may affect the interpretation of results.
Jongkonnee Wongpiyabovorn, Nasornthan Yutthakasaemsan, Sunida Vandelaer   +2 more
doaj   +2 more sources

Reference intervals for serum progastrin-releasing peptide in healthy Chinese adults with electrochemiluminescence immunoassay

The International Journal of Biological Markers, 2018
Background: Reliable reference intervals for serum progastrin-releasing peptide (ProGRP) in healthy Chinese adults with electrochemiluminescence immunoassay (ECLIA) are still lacking in the Chinese population.
Yuanqing Yang, Taiqing Zheng, Hongmin Jiang, Aiguo Tang, Zhongyuan Xiang   +4 more
doaj   +2 more sources

A deeper evaluation of cytokeratin fragment 21-1 as a lung cancer tumor marker and comparison of different assays

Biosensors and Bioelectronics: X
Studies show CYFRA 21-1 fragments of cytokeratin 19 (CK19) to be promising biomarkers for non-small cell lung cancer (NSCLC). Although previous literature identifies specific CYFRA 21-1 antibody binding epitopes, the exact molecular weight of the CK19 ...
Dianna J. Rowe, Timothy A. Khalil, Michael N. Kammer, Caroline M. Godfrey, Yong Zou, Cindy L. Vnencak-Jones, David Xiao, Stephen Deppen, Eric L. Grogan   +8 more
doaj   +2 more sources

Clinical performance of the Roche Elecsys SARS-CoV-2 antigen fully automated electrochemiluminescence immunoassay

Practical Laboratory Medicine, 2022
Objective: We assessed the clinical performance of novel Roche Elecsys SARS-CoV-2 Antigen fully automated electrochemiluminescence immunoassay (ECLIA). Design and methods: We tested 160 subjects, 110 (68.8%), with positive molecular test for SARS-CoV-2 ...
Gian Luca Salvagno, Laura Pighi, Simone De Nitto, Giuseppe Lippi   +3 more
doaj   +2 more sources

Low-level hepatitis B surface antigen by ECLIA stratifies early relapse risk in patients with interferon-based HBV functional cure [PDF]

Frontiers in Immunology
BackgroundCurrent definitions of functional cure in chronic hepatitis B (CHB) rely on conventional assays of HBsAg tested by enzyme-linked immunosorbent assay (ELISA-HBsAg), which may misclassify patients with low-level residual antigenemia as cured ...
Xiangyong Li, Baoer Wu, Huaping Xie, Hao Hu, Ting Liu, Xu You, Yanhua Bi, Yurong Gu   +7 more
doaj   +2 more sources

Sugammadex interference with serum progesterone measurement: an in-vitro study. [PDF]

Anaesthesia
Summary Introduction Sugammadex may interfere with serum progesterone immunoassays, potentially rendering measured concentrations and resulting recommendations unreliable. Methods We investigated the effect of a range of sugammadex concentrations on serum progesterone concentrations in samples from pre‐menopausal female volunteers.
Devoy T, Larkin T, Allan M, Mantik K, McShane M, Smith NA.   +5 more
europepmc   +2 more sources

Development of an ECLIA based assay for MeCP2 protein

, 2017
Background: Rett syndrome is a severe neurodevelopmental disease, occurring in one out of every 10.000 female births. It is mainly caused by mutations in the MeCP2 gene, leading to the corresponding protein’s loss of function. Potential therapeutical approaches still require research.
Schönegger, Anna Katharina
openaire   +2 more sources