Results 41 to 50 of about 164,374 (263)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis

Advanced Science
The photoreceptor cilium is vital for maintaining the structure and function of the retina. However, the molecular mechanisms underlying the photoreceptor cilium integrity and retinal homeostasis are largely unknown.
Jie Ran, Guizhi Guo, Sai Zhang, Yufei Zhang, Liang Zhang, Dengwen Li, Shian Wu, Yusheng Cong, Xiaohong Wang, Songbo Xie, Huijie Zhao, Hongbin Liu, Guangshuo Ou, Xueliang Zhu, Jun Zhou, Min Liu   +15 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Underrated Links Mitigate the Fragmentation‐Induced Mutualism Breakdown in a Large‐Fruited Species

Conservation Letters
Seed dispersal is threatened in fragmented landscapes by the loss of frugivores, significantly undermining the persistence of large‐fruited plant species that rely on large‐bodied animals.
Chen Zhu, Minghao Sun, Ahimsa Campos‐Arceiz, Wande Li, Di Zeng, Yao Shen, Guoqingzi Chen, Hongjun Xie, Ping Ding, Xingfeng Si   +9 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Warming overwhelms CO2-driven drought mitigation in alpine vegetation on the Qinghai-Tibetan Plateau

Communications Earth & Environment
Droughts have intensified under climate change, threatening ecosystem stability. While rising atmospheric CO2 concentrations may enhance vegetation drought resistance, the net effect remains uncertain amid concurrent warming.
He Lyu, Xueqian Zhang, Jian Su, David Wårlind, Jürgen Knauer, Lina Teckentrup, Jinfeng Chang, Xiyan Xu, Chen Chen, Juntao Zhu, Jian Ni, Stephen Sitch, Yongshuo Fu, Belinda Medlyn, Benjamin Smith, Yuanhe Yang, Mingkai Jiang   +16 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Evaluating the Impact of Environmental Factors on Bacterial Populations in Riverine, Estuarine, and Coastal Sediments

Diversity
Aquatic ecosystems, including rivers, estuaries, and coastal environments, are crucial for maintaining biodiversity, regulating nutrient cycles, and supporting human livelihoods. However, these ecosystems are increasingly being threatened by urbanization,
Ramganesh Selvarajan, Ming Yang, Henry J. O. Ogola, Timothy Sibanda, Akebe Luther King Abia   +4 more
doaj   +1 more source

An evolutionary approach to ecosystem functioning [PDF]

Proceedings of the National Academy of Sciences, 2001
The more diversified in habits and structure the descendants of our carnivorous animal became, the more places they would be enabled to occupy. What applies to one animal will apply throughout all time to all animals… So it will be with plants. It has been experimentally proved, that if a plot of ground be sown with several distinct genera of grasses ...
openaire   +2 more sources