Results 51 to 60 of about 34,736 (238)

Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays

Advanced Science, EarlyView.
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen, Yuman Li, Chenyu Deng, Leran Li, Zhewen Hu, Boon Chin Heng, Yuting Niu, Shiyu Sun, Min Gao, Xiaopei Chi, Ying He, Mingming Xu, Ying Huang, Xuliang Deng   +13 more
wiley   +1 more source

Body Cavity Development Is Guided by Morphogen Transfer between Germ Layers

Cell Reports, 2018
Summary: The body cavity is a space where internal organs develop and are placed. Despite the importance of this internal space, how the body cavity forms specifically within the mesoderm remains largely unknown.
Jan Schlueter, Takashi Mikawa
doaj   +1 more source

Ectoderm-derived frontal bone mesenchymal stem cells promote traumatic brain injury recovery by alleviating neuroinflammation and glutamate excitotoxicity partially via FGF1

Stem Cell Research & Therapy, 2022
Background Traumatic brain injury (TBI) leads to cell and tissue impairment, as well as functional deficits. Stem cells promote structural and functional recovery and thus are considered as a promising therapy for various nerve injuries.
Qiaozhen Qin, Ting Wang, Zhenhua Xu, Shuirong Liu, Heyang Zhang, Zhangzhen Du, Jianing Wang, Yadi Wang, Zhenning Wang, Shanshan Yuan, Jiamei Wu, Wenyan He, Changzhen Wang, Xinlong Yan, Yan Wang, Xiaoxia Jiang   +15 more
doaj   +1 more source

Dental crown morphological variation and heterodonty in carcharhiniform sharks

The Anatomical Record, EarlyView.
Abstract Elasmobranch teeth are highly mineralized structures that constitute the majority of the fossil record for this group. Despite their taxonomic and evolutionary significance, detailed descriptions of dental morphology remain scarce. The order Carcharhiniformes, the most diverse among sharks, comprises 304 valid species that display remarkable ...
Flávia Zanini, Karla D. A. Soares
wiley   +1 more source

Early stages of tooth development in the harbor porpoise Phocoena phocoena

The Anatomical Record, EarlyView.
Abstract Here we describe the stages of tooth development in toothed whales on the basis of the harbor porpoise (Phocoena phocoena). The aim of the study was to find out whether these stages are identical to those of other mammals analyzed so far although toothed whales are homodont and monophyodont.
Lasse M. Mathes, Lennart Müller‐Thomsen, Stefan Huggenberger   +2 more
wiley   +1 more source

Differential genetic mutations of ectoderm, mesoderm, and endoderm-derived tumors in TCGA database

Cancer Cell International, 2020
Background In terms of biological behavior, gene regulation, or signaling pathways, there is a certain similarity between tumorigenesis and embryonic development of humans. Three germ layer structure exhibits the distinct ability to form specific tissues
Xingjie Gao, Xiaoteng Cui, Xinxin Zhang, Chunyan Zhao, Nan Zhang, Yan Zhao, Yuanyuan Ren, Chao Su, Lin Ge, Shaoyuan Wu, Jie Yang   +10 more
doaj   +1 more source

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, EarlyView.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Three-Dimensional Trilineage Differentiation Conditions for Human Induced Pluripotent Stem Cells

Bioengineering
Human induced pluripotent stem cells (hiPSCs) hold great potential for regenerative medicine. However, optimizing their differentiation into specific lineages within three-dimensional (3D) scaffold-based culture systems that mimic in vivo environments ...
Md Sharifur Rahman, Guangyan Qi, Quan Li, Xuming Liu, Jianfa Bai, Mingshun Chen, Anthony Atala, Xiuzhi Susan Sun   +7 more
doaj   +1 more source

Ectodermal dysplasia [PDF]

Česká stomatologie a praktické zubní lékařství, 2013
Background: Ectodermal dysplasia is a rare, genetically determined disease, which is characterized by alterations in two or more ectodermal structures, at least one of these involving alterations in hair, teeth, nails, or sweat glands. It is estimated that about seven in 10 000 births are affected with a form ectodermal dysplasia.
L. Kramerová, E. Kaplová
openaire   +2 more sources

Modern competency‐based teaching of human sexual development

Anatomical Sciences Education, EarlyView.
Abstract Embryology is an integral part of anatomy and a key subject in basic medical education. The development of the sexual tract, which is closely associated with the formation of the urinary tract and the organs of continence, is particularly complex and relevant for many medical disciplines.
Elisabeth Eppler, Alessandro Bilella, Christian M. Hammer   +2 more
wiley   +1 more source