Results 61 to 70 of about 183,658 (172)

The Paracrine Role of Endothelial Cells in Bone Formation via CXCR4/SDF-1 Pathway

Cells, 2020
Vascularization is a prerequisite for bone formation. Endothelial progenitor cells (EPCs) stimulate bone formation by creating a vascular network. Moreover, EPCs secrete various bioactive molecules that may regulate bone formation.
Tal Tamari, Rawan Kawar-Jaraisy, Ofri Doppelt, Ben Giladi, Nadin Sabbah, Hadar Zigdon-Giladi   +5 more
doaj   +1 more source

Long‐Term Expandable Periosteal Organoids Reconstruct a Functional Regenerative Niche That Support Hematopoietic Stem Cell Maintenance and Bone Repair

Advanced Science, EarlyView.
A robust periosteal organoid system enables long‐term expansion while preserving native cellular heterogeneity. These organoids recapitulate functional niche environments, support hematopoietic stem cell maintenance, and attenuate aging‐associated decline ex vivo.
Jia Qing, Lanxin Gu, Lipeng Fu, Xin Gao, Zechuan Li, Hui Zhang, Wenpeng Song, Huixin Lv, Yongsheng Zhou, Ping Zhang   +9 more
wiley   +1 more source

Fuyuan Huoxue Decoction Promotes Lumbar Interbody Fusion in Rats: Role of Macrophage‐Driven Inflammation and the TLR9/NF‐κB Pathway

Advanced Science, EarlyView.
Fuyuan Huoxue decoction improves lumbar interbody fusion in rats while reducing inflammatory macrophage activity and supporting bone‐forming stem cells. Experiments implicate extracellular DNA and TLR9/NF‐κB signaling in early responses. These findings point to coordinated control of inflammation and osteogenesis as a potential route to stronger spinal
Hongwei Gao, Han Wu, Shaorong Li, Weijian Wang, Yijian Guo, Shuai Cheng, Jiayi Sun, Jilong An, Wei Zhang   +8 more
wiley   +1 more source

Variable patterns of ectopic mineralization in Enpp1asj-2J mice, a model for generalized arterial calcification of infancy. [PDF]

, 2016
Generalized arterial calcification of infancy (GACI) is an autosomal recessive disorder characterized by early onset of extensive mineralization of the cardiovascular system. The classical forms of GACI are caused by mutations in the ENPP1 gene, encoding
Dyment, Nathaniel A., Rowe, David W., Rowe, David W, Siu, Sarah Y., Uitto, Jouni, Dyment, Nathaniel A, Sundberg, John P., Sundberg, John P, Li, Qiaoli, Siu, Sarah Y   +9 more
core   +2 more sources

A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. [PDF]

PLoS ONE, 2015
Ectopic calcification is a driving force for a variety of diseases, including kidney stones and atherosclerosis, but initiating factors remain largely unknown.
Thomas Chi, Man Su Kim, Sven Lang, Neelanjan Bose, Arnold Kahn, Lawrence Flechner, Sarah D Blaschko, Tiffany Zee, Gulinuer Muteliefu, Nichole Bond, Marysia Kolipinski, Sirine C Fakra, Neil Mandel, Joe Miller, Arvind Ramanathan, David W Killilea, Katja Brückner, Pankaj Kapahi, Marshall L Stoller   +18 more
doaj   +1 more source

Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6

, 2019
Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic mineralization disorders, is caused by mutations in the ABCC6 gene encoding a putative efflux transporter ABCC6.
Millan, Jose Luis, van Zelst, Bertrand D, Pinkerton, Anthony B, Uitto, Jouni, Huang, Jianhe, Sundberg, John P, Li, Qiaoli, Levine, Michael A, Li, QL, Uitto, J, Huang, JH, Pinkerton, AB, Millan, JL, van Zelst, Bertrand, Sundberg, JP, Levine, MA   +15 more
core   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype

Cellular & Molecular Biology Letters, 2017
Background Pseudoxanthoma elasticum (PXE) is characterized by progressive ectopic mineralization of elastic fibers in dermal, ocular and vascular tissues. No effective treatment exists.
Rocchina Miglionico, Angela Ostuni, Maria Francesca Armentano, Luigi Milella, Elvira Crescenzi, Monica Carmosino, Faustino Bisaccia   +6 more
doaj   +1 more source

Quantitative Trait Locus and Integrative Genomics Revealed Candidate Modifier Genes for Ectopic Mineralization in Mouse Models of Pseudoxanthoma Elasticum.

, 2019
Pseudoxanthoma elasticum, a prototype of heritable multisystem ectopic mineralization disorders, is caused by mutations in the ABCC6 gene encoding a putative efflux transporter, ABCC6.
Wiles, Michael V, Philip, Vivek M, Uitto, Jouni, Bubier, Jason A, Stearns, Timothy M, Sundberg, John P, Sundberg, Beth A, Li, Qiaoli, Low, Benjamin E, King, Benjamin L, Saeidian, Amir Hossein   +10 more
core   +1 more source

Development‐Informed Microsphere Assemblies Enable Spatiotemporally Programmed Bone–Vascular Organoid‐Like Constructs for Large Bone Defect Repair

Advanced Science, EarlyView.
Single‐cell‐guided prioritization of BMP4 and VEGFA is combined with temporally programmed BMSCs and a Matrigel‐free GelMA/PEO/bioactive‐glass assembled‐microsphere matrix to generate bone–vascular organoid‐like constructs. The platform coordinates osteogenic differentiation, endothelial activation, vascular‐like microchannel formation, and ...
Renhao Ni, Xinyi Shi, Tong Zhu, Guanrong Li, Lei Chang, Shengtao Li, Jingyi Chi, Chen Shi, Zeming Hu, Rong Xu, Yingchun Zhu, Yang Luo, Yichen Chen, Fan Yang, Yabin Zhu   +14 more
wiley   +1 more source