Results 41 to 50 of about 183,658 (172)

Adenovirus-Mediated ABCC6 Gene Therapy for Heritable Ectopic Mineralization Disorders [PDF]

Journal of Investigative Dermatology, 2019
Loss-of-function mutations in the ABCC6 gene cause pseudoxanthoma elasticum and type 2 generalized arterial calcification of infancy, heritable ectopic mineralization disorders without effective treatment. ABCC6 encodes the putative efflux transporter ABCC6, which is predominantly expressed in the liver. Although the substrate of ABCC6 remains unknown,
Jianhe, Huang, Adam E, Snook, Jouni, Uitto, Qiaoli, Li   +3 more
openaire   +2 more sources

Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI) and pseudoxanthoma elasticum (PXE)

Disease Models & Mechanisms, 2014
In recent years it has become clear that, mechanistically, biomineralization is a process that has to be actively inhibited as a default state. This inhibition must be released in a rigidly controlled manner in order for mineralization to occur in ...
Alexander Apschner, Leonie F. A. Huitema, Bas Ponsioen, Josi Peterson-Maduro, Stefan Schulte-Merker   +4 more
doaj   +1 more source

Micropatterning biomineralization with immobilized mother of pearl proteins

Scientific Reports, 2021
In response to the drawbacks of autograft donor-site morbidity and bone morphogenetic protein type 2 (BMP2) carcinogenesis and ectopic bone formation, there has been an increased research focus towards developing alternatives capable of achieving spatial
Kristopher A. White, Vincent J. Cali, Ronke M. Olabisi   +2 more
doaj   +1 more source

Ectopic mineral formation in the prostate gland

Морфологія, 2011
This work analyzes the data of contemporary scientific literature regarding the ectopic mineralization in the prostate gland, its pathogenetic features are considered.The scientific literature of recent decades gives grounds to assert that the processes of concrement formation in the prostate gland are influenced by many factors, pathological ...
Moskalenko, R. A., Romanyuk, A. M., Zakorko, I-M. S., Piddubny, A. M.   +3 more
openaire   +4 more sources

Contribution of matrix vesicles and alkaline phosphatase to ectopic bone formation

Brazilian Journal of Medical and Biological Research, 2006
Endochondral calcification involves the participation of matrix vesicles (MVs), but it remains unclear whether calcification ectopically induced by implants of demineralized bone matrix also proceeds via MVs.
P. Ciancaglini, A.M.S. Simão, F.L. Camolezi, J.L. Millán, J.M. Pizauro   +4 more
doaj   +1 more source

Gingival epithelial cell-derived microvesicles activate mineralization in gingival fibroblasts

Scientific Reports, 2022
Soft tissue calcification occurs in many parts of the body, including the gingival tissue. Epithelial cell-derived MVs can control many functions in fibroblasts but their role in regulating mineralization has not been explored.
Shuichiro Kobayashi, Jiarui Bi, Gethin Owen, Nelli Larjava, Leeni Koivisto, Lari Häkkinen, Hannu Larjava   +6 more
doaj   +1 more source

Ectopic Bone Tissue Engineering in Mice Using Human Gingiva or Bone Marrow-Derived Stromal/Progenitor Cells in Scaffold-Hydrogel Constructs

Frontiers in Bioengineering and Biotechnology, 2021
Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation and bone regeneration capacity of mesenchymal stromal cells (MSC). Gingiva-derived progenitor cells (GPC) represent a less invasive alternative to bone marrow MSC (BMSC ...
Siddharth Shanbhag, Siddharth Shanbhag, Carina Kampleitner, Carina Kampleitner, Carina Kampleitner, Samih Mohamed-Ahmed, Mohammed Ahmad Yassin, Harsh Dongre, Harsh Dongre, Daniela Elena Costea, Daniela Elena Costea, Stefan Tangl, Stefan Tangl, Mohamad Nageeb Hassan, Andreas Stavropoulos, Andreas Stavropoulos, Anne Isine Bolstad, Salwa Suliman, Kamal Mustafa   +18 more
doaj   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

BAP31 Drives Cartilage Calcification through Disruption of Autophagosome–Lysosome Fusion in Osteoarthritis

Advanced Science, EarlyView.
Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu, Ruo‐xin Wang, Feng He, Qian Liu, Fu‐yin Li, Min Hui, Yu‐qian Shi, Yu Jiang, Qing‐hua Li, Jun‐wen Jing, Shi‐bin Yu, Li‐tian Ma, Qian‐nan Niu, Mian Zhang   +13 more
wiley   +1 more source

Ectopic calcification of the abdominal aorta and bone mineral content of vertebrae.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1989
The relationship between the ectopic calcification of abdominal aorta and the de-calcification of bone in 137 elderly patients was investigated by quantitative computed tomography. We calculated the index (CAI) of the calcification volume to the aorta volume in the lower abdominal aorta, and simultaneously estimated the bone mineral content (BMC) of ...
Sugihara, Nobuyuki, Matsuzaki, Masunori, Kato, Yukiko   +2 more
openaire   +3 more sources