P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles [PDF]
Frontiers in Pharmacology, 2022 Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral ...
Robin M. H. Rumney +6 more
doaj +7 more sources
Hexasodium Fytate (SNF472 or CSL525) Inhibits Ectopic Calcification in Various Pseudoxanthoma Elasticum and Calcinosis Cutis Animal Models [PDF]
PharmaceuticalsBackground/Objectives: Ectopic calcification is a pathological condition characterized by the mineralization of soft tissues due to the deposition of calcium phosphate crystals.
Miguel D. Ferrer +11 more
doaj +5 more sources
Liver-directed base editing of ABCC6 prevents ectopic calcification in a variant-humanized mouse model of pseudoxanthoma elasticum [PDF]
Molecular Therapy: Nucleic AcidsPseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries.
Lauren C. Testa +8 more
doaj +3 more sources
Evocalcet prevents ectopic calcification and parathyroid hyperplasia in rats with secondary hyperparathyroidism. [PDF]
PLoS ONE, 2020 BACKGROUND:Elevated parathyroid hormone (PTH) levels in secondary hyperparathyroidism (SHPT) lead to vascular calcification, which is associated with cardiovascular events and mortality.
Mariko Sakai +7 more
doaj +3 more sources
Activation of Nuclear Factor Erythroid 2-Related Factor 2 Transcriptionally Upregulates Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Expression and Inhibits Ectopic Calcification in Mice [PDF]
AntioxidantsCalcification plays a key role in biological processes, and breakdown of the regulatory mechanism results in a pathological state such as ectopic calcification.
Ida Tomomi +9 more
doaj +3 more sources
Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies [PDF]
International Journal of Molecular Sciences, 2023 Ectopic calcification refers to the pathological accumulation of calcium ions in soft tissues and is often the result of a dysregulated action or disrupted function of proteins involved in extracellular matrix mineralization.
Vincent Laizé +2 more
exaly +4 more sources
Anticalcification effects of DS-1211 in pseudoxanthoma elasticum mouse models and the role of tissue-nonspecific alkaline phosphatase in ABCC6-deficient ectopic calcification [PDF]
Scientific Reports, 2022 Pseudoxanthoma elasticum (PXE) is a multisystem, genetic, ectopic mineralization disorder with no effective treatment. Inhibition of tissue-nonspecific alkaline phosphatase (TNAP) may prevent ectopic soft tissue calcification by increasing endogenous ...
Kaori Soma +2 more
doaj +2 more sources
ENPP1 variants in patients with GACI and PXE expand the clinical and genetic heterogeneity of heritable disorders of ectopic calcification. [PDF]
PLoS Genetics, 2022 Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are clinically distinct genetic entities of ectopic calcification associated with differentially reduced circulating levels of inorganic pyrophosphate (PPi), a potent
Douglas Ralph +11 more
doaj +2 more sources
The liver regulates ectopic calcification in Abcc6-deficient models of pseudoxanthoma elasticum [PDF]
The Journal of Clinical InvestigationPseudoxanthoma Elasticum (PXE) is a rare disease caused by loss of function of the ATP-binding cassette C (ABC) member 6 (Abcc6) gene and characterized by ectopic calcification of multiple tissues, but the physiological reasons underlying ectopic ...
Yijie Wang +19 more
doaj +2 more sources
Weighing the Evidence for the Roles of Plasma Versus Local Pyrophosphate in Ectopic Calcification Disorders [PDF]
Journal of Bone and Mineral Research, 2023 José Luis Millán +2 more
exaly +2 more sources