Results 1 to 10 of about 342 (112)
P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles [PDF]
Frontiers in Pharmacology, 2022 Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral ...
Robin Rumney +2 more
exaly +6 more sources
Angiogenesis and Pericytes in the Initiation of Ectopic Calcification [PDF]
Circulation Research, 2005 Ectopic calcification of blood vessels, heart valves, and skeletal muscle is a major clinical problem. There is now good evidence that angiogenesis is associated with ectopic calcification in these tissues and that it is necessary, but not sufficient, for calcification to occur. Angiogenesis may regulate ectopic calcification in several ways.
A E Canfield
exaly +4 more sources
The Role of Sclerostin in Bone and Ectopic Calcification [PDF]
International Journal of Molecular Sciences, 2020 Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it leads to an increased bone resorption and decreased bone formation. Serum sclerostin levels are known to be increased in the elderly and in patients with chronic kidney ...
Anja Verhulst +2 more
exaly +4 more sources
Future treatments for the arteriopathy of ectopic calcification disorders
Frontiers in Drug Discovery, 2023 Ectopic calcification disorders, including Generalized Arterial Calcification of Infancy (GACI) and Pseudoxanthoma Elasticum are rare but impactful on individuals, healthcare and society, with significant associated morbidity, mortality and healthcare ...
Naren Vyavahare, Frank Rutsch
exaly +3 more sources
ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions [PDF]
International Journal of Molecular Sciences, 2021 Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic disorders. Pseudoxanthoma elasticum (PXE), a multi-organ disease affecting dermal, ocular, and cardiovascular tissues, is a model for ectopic mineralization disorders ...
Ludovic Martin +2 more
exaly +3 more sources
Role of carbonic anhydrase II in ectopic calcification [PDF]
Cardiovascular Pathology, 2009 Osteopontin (OPN) is a potent inhibitor of ectopic calcification. Previous studies suggested that, in addition to blocking apatite crystal growth, OPN promoted regression of ectopic calcification by inducing the expression of acid-generating carbonic anhydrase II (CAR2) in monocyte-derived cells.To test this hypothesis, OPN and CAR2 expression and ...
Rupak M, Rajachar +4 more
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PharmaceuticalsBackground/Objectives: Ectopic calcification is a pathological condition characterized by the mineralization of soft tissues due to the deposition of calcium phosphate crystals.
Qiaoli Li +2 more
exaly +3 more sources
Advances in Pseudoxanthoma Elasticum
罕见病研究, 2023 Pseudoxanthoma elasticum(PXE) is a rare, genetic, metabolic disease characterized by ectopic calcification of connective tissue that primarily affects the skin, retina and cardiovascular system, which characteristic histopathology is calcification and ...
WANG Huifen, ZHAI Zhifang
doaj +1 more source
The Case | Ectopic calcifications in a child [PDF]
Kidney International, 2015 A 9-year-old boy, born of third-degree consanguinity, presented with a hard left scapular swelling that had been persistent for 6 months. There was no history of fever, trauma, or weight loss. There was no pain, redness, or discharge. This mass was excised but recurred over the next 6 months (left panel of Figure 1). A similar swelling had been excised
Keskar, Vaibhav S. +6 more
openaire +2 more sources
Bone Reports, 2021 Equilibrative nucleoside transporter 1 (ENT1) transfers nucleosides, such as adenosine, across plasma membranes. We reported previously that mice lacking ENT1 (ENT1−/−) exhibit progressive ectopic calcification of spinal tissues—a phenotype resembling ...
Dale E. Fournier +5 more
doaj +1 more source