Results 41 to 50 of about 116,653 (132)

αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish

Cell Reports, 2019
Summary: The hormone αKlotho regulates lifespan in mice, as knockouts die early of what appears to be accelerated aging due to hyperphosphatemia and soft tissue calcification. In contrast, the overexpression of αKlotho increases lifespan.
Ajeet Pratap Singh, Maria X. Sosa, Jian Fang, Shiva Kumar Shanmukhappa, Alexis Hubaud, Caroline H. Fawcett, Gregory J. Molind, Tingwei Tsai, Paola Capodieci, Kristie Wetzel, Ellen Sanchez, Guangliang Wang, Matthew Coble, Wenlong Tang, Samuel M. Cadena, Mark C. Fishman, David J. Glass   +16 more
doaj   +1 more source

AGEs induce ectopic endochondral ossification in intervertebral discs [PDF]

European Cells & Materials, 2016
Ectopic calcifications in intervertebral discs (IVDs) are known characteristics of IVD degeneration that are not commonly reported but may be implicated in structural failure and dysfunctional IVD cell metabolic responses.
S Illien-Jünger, OM Torre, WF Kindschuh, X Chen, DM Laudier, JC Iatridis   +5 more
doaj   +1 more source

Surgical Excision of a Left Atrial Mobile Stalked Calcification Arising After Multiple Radiofrequency Ablations

JACC: Case Reports, 2023
We report a rare case of a mobile ectopic calcification in the left atrium requiring surgical excision 9 years after multiple atrial fibrillation ablations. (Level of Difficulty: Intermediate.)
Tadanori Nakata, MD, Naoyuki Miwa, MD, Yoshikazu Sato, MD, Kazuya Yamao, MD, Hitoshi Hachiya, MD   +4 more
doaj   +1 more source

Matrix Gla protein negatively regulates calcification of human aortic valve interstitial cells isolated from calcified aortic valves

Journal of Pharmacological Sciences, 2018
Calcified aortic valve stenosis (CAS) is a common heart valve disease in elderly people, and is mostly accompanied by ectopic valve calcification. We recently demonstrated that tumor necrosis factor-α (TNF-α) induces calcification of human aortic valve ...
Mari Chiyoya, Kazuhiko Seya, Zaiqiang Yu, Kazuyuki Daitoku, Shigeru Motomura, Tadaatsu Imaizumi, Ikuo Fukuda, Ken-Ichi Furukawa   +7 more
doaj   +1 more source

Petrified Ears: A Clue for Adrenal Insufficiency

Dermatopathology, 2021
Petrified ears is an uncommon clinical entity. It describes auricular cartilage hardening, due usually to ectopic calcification or, less commonly, ossification. The most common causes are frostbite and mechanical trauma.
Sebastiano Recalcati, Fabrizio Fantini
doaj   +1 more source

1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1

Journal of Pharmacological Sciences, 2016
An abnormally high serum phosphate level induces calcific aortic stenosis (CAS), which is characterized by ectopic valve calcification and stenosis of the orifice area.
Kazuhiko Seya, Ken-Ichi Furukawa, Mari Chiyoya, Zaiqiang Yu, Haruhisa Kikuchi, Kazuyuki Daitoku, Shigeru Motomura, Manabu Murakami, Yoshiteru Oshima, Ikuo Fukuda   +9 more
doaj   +1 more source

Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice. [PDF]

PLoS ONE, 2015
Intervertebral disc (IVD) degeneration and pathological spinal changes are major causes of back pain, which is the top cause of global disability. Obese and diabetic individuals are at increased risk for back pain and musculoskeletal complications ...
Svenja Illien-Jünger, Young Lu, Sheeraz A Qureshi, Andrew C Hecht, Weijing Cai, Helen Vlassara, Gary E Striker, James C Iatridis   +7 more
doaj   +1 more source

The Interplay Between Brain Vascular Calcification and Microglia

Frontiers in Aging Neuroscience, 2022
Vascular calcifications are characterized by the ectopic deposition of calcium and phosphate in the vascular lumen or wall. They are a common finding in computed tomography scans or during autopsy and are often directly related to a pathological ...
Upasana Maheshwari, Sheng-Fu Huang, Sucheta Sridhar, Sucheta Sridhar, Annika Keller, Annika Keller   +5 more
doaj   +1 more source

Oral administration of pyrophosphate inhibits connective tissue calcification

EMBO Molecular Medicine, 2017
Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI), which are caused by inactivating mutations in ABCC6 and ENPP1, respectively, present with extensive tissue calcification due to reduced ...
Dóra Dedinszki, Flóra Szeri, Eszter Kozák, Viola Pomozi, Natália Tőkési, Tamás Róbert Mezei, Kinga Merczel, Emmanuel Letavernier, Ellie Tang, Olivier Le Saux, Tamás Arányi, Koen van de Wetering, András Váradi   +12 more
doaj   +1 more source

The role of vitamins K and D in the processes of ectopic calcification in patients with chronic kidney disease: The current state of the problem

Український Журнал Нефрології та Діалізу, 2022
. The generalization of experimental and clinical data currently allows us to confirm the important pathogenetic role of vitamin K deficiency in cardiovascular calcification and atherosclerotic damage in chronic kidney disease (CKD).
O. Susla, O. Bushtynska, S. Danyliv, L. Logoyda, A. Gozhenko   +4 more
doaj   +1 more source