Results 51 to 60 of about 116,653 (132)

Expression of Calcification and Extracellular Matrix Genes in the Cardiovascular System of the Healthy Domestic Sheep (Ovis aries)

Frontiers in Genetics, 2020
The maintenance of a healthy cardiovascular system requires expression of genes that contribute to essential biological activities and repression of those that are associated with functions likely to be detrimental to cardiovascular homeostasis. Vascular
Hiu-Gwen Tsang, Emily L. Clark, Greg R. Markby, Stephen J. Bush, Stephen J. Bush, David A. Hume, Brendan M. Corcoran, Vicky E. MacRae, Kim M. Summers, Kim M. Summers   +9 more
doaj   +1 more source

The PROPHECI trial: a phase II, double-blind, placebo-controlled, randomized clinical trial for the treatment of pseudoxanthoma elasticum with oral pyrophosphate

Trials
Background /aims. Pseudoxanthoma Elasticum (PXE, OMIM 264800) is an autosomal, recessive, metabolic disorder characterized by progressive ectopic calcification in the skin, the vasculature and Bruch’s membrane.
Laetitia Clotaire, Isabelle Rubera, Christophe Duranton, Jocelyn Gal, Emmanuel Chamorey, Hélène Humeau, Samir Yamani, Christine Chiaverini, Serge Willoteaux, Bernard Padovani, Laurie Mourozeau, Adam Mainguy, Stéphanie Baillif, Ludovic Martin, Georges Leftheriotis   +14 more
doaj   +1 more source

The molecular and physiological roles of ABCC6: more than meets the eye

Frontiers in Genetics, 2012
Abnormal mineralization occurs in the context of several common conditions, including advanced age, diabetes, hypercholesterolemia, chronic renal failure and certain genetic conditions. Metabolic, mechanical, infectious, and inflammatory injuries promote
Olivier eLe Saux, Ludovic eMartin, Zouhair eAherrahrou, Georges eLeftheriotis, Andras eVaradi, Christopher N. Brampton   +5 more
doaj   +1 more source

Inhibition of the DNA Damage Response Attenuates Ectopic Calcification in Pseudoxanthoma Elasticum

, 2022
Pseudoxanthoma elasticum (PXE) is a heritable ectopic calcification disorder with multiorgan clinical manifestations. The gene at default, ABCC6, encodes an efflux transporter, ABCC6, which is a critical player regulating the homeostasis of inorganic ...
Qiaoli Li, Jouni Uitto, Uitto, Jouni, Douglas Ralph, Ralph, Douglas, Quaglino, Daniela, Daniela Quaglino, Huang, Jianhe, Jianhe Huang, Li, Qiaoli, Federica Boraldi, Boraldi, Federica   +11 more
core   +1 more source

The liver regulates ectopic calcification in Abcc6-deficient models of pseudoxanthoma elasticum

The Journal of Clinical Investigation
Pseudoxanthoma Elasticum (PXE) is a rare disease caused by loss of function of the ATP-binding cassette C (ABC) member 6 (Abcc6) gene and characterized by ectopic calcification of multiple tissues, but the physiological reasons underlying ectopic ...
Yijie Wang, Baiming Sun, Feiyang Ma, Bo Tao, Yiqian Gu, Zhiqiang Zhou, Jason Kim, Linlin Zhang, Zhihao Liu, Johanna ten Hoeve, Linsey Stiles, Lucia Fernandez del Rio, Calvin Pan, Orian Shirihai, Shili Xu, Thomas G. Graeber, Tamer Sallam, Matteo Pellegrini, Aldons J. Lusis, Arjun Deb   +19 more
doaj   +1 more source

Vascular calcifying progenitor cells possess bidirectional differentiation potentials. [PDF]

PLoS Biology, 2013
Vascular calcification is an advanced feature of atherosclerosis for which no effective therapy is available. To investigate the modulation or reversal of calcification, we identified calcifying progenitor cells and investigated their calcifying ...
Hyun-Ju Cho, Hyun-Jai Cho, Ho-Jae Lee, Myung-Kang Song, Ji-Yun Seo, Yeon-Hee Bae, Ju-Young Kim, Hae-Young Lee, Whal Lee, Bon-Kwon Koo, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim   +12 more
doaj   +1 more source

Does the Location of Fat Accumulation Affect the Degree of Aortic and Renal Arterial Calcification?

Biomedicines
The vascular risk associated with obesity is particularly associated with visceral adiposity, but recent studies suggest that ectopic fat might contribute to the increased risk of atherosclerotic cardiovascular disease.
Ivan Ordulj, Mirko Tandara, Kristian Jerković, Frano Šarić, Miodrag Beneš, Sanja Lovrić Kojundžić, Maja Marinović Guić, Danijela Budimir Mršić   +7 more
doaj   +1 more source

A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation

Marine Drugs, 2020
Worldwide diffused diseases such as osteoarthritis, atherosclerosis or chronic kidney disease are associated with a tissue calcification process which may involve unexpected local stem cell differentiation.
Pietro Marchese, Nipun Mahajan, Enda O’Connell, Howard Fearnhead, Maria Tuohy, Janusz Krawczyk, Olivier P. Thomas, Frank Barry, Mary J. Murphy   +8 more
doaj   +1 more source

Video3_P2X7 Purinoceptor Affects Ectopic Calcification of Dystrophic Muscles.AVI

, 2022
Ectopic calcification (EC) of myofibers is a pathological feature of muscle damage in Duchenne muscular dystrophy (DMD). Mineralisation of muscle tissue occurs concomitantly with macrophage infiltration, suggesting a link between ectopic mineral ...
Robin M. H. Rumney (4672501), Rasha Al-Khalidi (812573), Natalia Chira (5090891), Dariusz C. Górecki (635319), Justyna Róg (5090909), Alexander P. Kao (5794904)   +5 more
core   +1 more source

Accelerated Growth Plate Mineralization and Foreshortened Proximal Limb Bones in Fetuin-A Knockout Mice [PDF]

, 2012
PMCID: PMC3473050This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Himadri S Gupta, Stefanie Krauss, Philip Catalá-Lehnen, Willi Jahnen-Dechent, Busse, Björn, Michael Kerschnitzki (126715), Busse, B., Peter Fratzl (126726), Jahnen-Dechent Willi, Fratzl, P., Zaslansky, Paul, Jahnen-Dechent, W., Schäfer, Caro, Jong Seto (126700), Kerschnitzki, Michael, Schäfer, Cora, Admir Masic (126713), Kerschnitzki Michael, Gupta, H., Masic, A., Björn Busse, Stefanie Krauss (126706), Paul Zaslansky (126717), Seto Jong, Himadri S. Gupta (126704), Jahnen-Dechent, Willi, Bösecke, Peter, Peter Boesecke (126719), Gupta, Himradi S., John W. C. Dunlop (126709), Admir Masic, Thorsten Schinke, Catalá-Lehnen, Philip, Catalá-Lehnen Philip, Cora Schäfer (126705), Schaefer, C, Thorsten Schinke (126724), Masic, Admir, Willi Jahnen-Dechent (126728), John W C Dunlop, Kerschnitzki, M., Michael Kerschnitzki, Schäfer, C., Krauss, Stefanie, Fratzl, P, Catala-Lehnen, P, Boesecke Peter, Dunlop, J., Gupta Himadri S., Masic, A, Peter Boesecke, Schinke, T, Peter Fratzl, Jahnen-Dechent, W, Schinke Thorsten, Catala-Lehnen, P., Paul Zaslansky, Zaslansky, P., Philip Catalá-Lehnen (126722), Boesecke, Peter, Seto, Jong, Schinke, T., Busse, B, Krauss, S, Björn Busse (126702), Seto, J, Schäfer Cora, Boesecke, P., Gupta, Himadri S., Boesecke, P, Cora Schäfer, Krauss, S., Dunlop, John W. C., Dunlop John W. C., Jong Seto, Busse Björn, Schinke, Thorsten, Masic Admir, Krauss Stefanie, Zaslansky Paul, Gupta, HS, Kerschnitzki, M, Dunlop, JWC, Zaslansky, P, Fratzl, Peter, Seto, J., Jahnen-Dechent, Wilhelm, Fratzl Peter   +87 more
core   +2 more sources