Results 31 to 40 of about 116,653 (132)

A Drosophila model identifies a critical role for zinc in mineralization for kidney stone disease. [PDF]

PLoS ONE, 2015
Ectopic calcification is a driving force for a variety of diseases, including kidney stones and atherosclerosis, but initiating factors remain largely unknown.
Thomas Chi, Man Su Kim, Sven Lang, Neelanjan Bose, Arnold Kahn, Lawrence Flechner, Sarah D Blaschko, Tiffany Zee, Gulinuer Muteliefu, Nichole Bond, Marysia Kolipinski, Sirine C Fakra, Neil Mandel, Joe Miller, Arvind Ramanathan, David W Killilea, Katja Brückner, Pankaj Kapahi, Marshall L Stoller   +18 more
doaj   +1 more source

Matrix Metalloproteinases Contribute to the Calcification Phenotype in Pseudoxanthoma Elasticum

Biomolecules, 2023
Ectopic calcification and dysregulated extracellular matrix remodeling are prominent hallmarks of the complex heterogenous pathobiochemistry of pseudoxanthoma elasticum (PXE).
Ricarda Plümers, Christopher Lindenkamp, Michel Robin Osterhage, Cornelius Knabbe, Doris Hendig   +4 more
doaj   +1 more source

Activation of Nuclear Factor Erythroid 2-Related Factor 2 Transcriptionally Upregulates Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 Expression and Inhibits Ectopic Calcification in Mice

Antioxidants
Calcification plays a key role in biological processes, and breakdown of the regulatory mechanism results in a pathological state such as ectopic calcification.
Ida Tomomi, Hiroyuki Kanzaki, Miho Shimoyama, Syunnosuke Tohyama, Misao Ishikawa, Yuta Katsumata, Chihiro Arai, Satoshi Wada, Shugo Manase, Hiroshi Tomonari   +9 more
doaj   +1 more source

Runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligament. [PDF]

PLoS ONE, 2012
Ossification of the Posterior Longitudinal Ligament (OPLL) is a disease that is characterized by the ectopic calcification of the ligament; however, the pathogenesis of OPLL remains to be investigated.
Makiko Iwasaki, Jinying Piao, Ayako Kimura, Shingo Sato, Hiroyuki Inose, Hiroki Ochi, Yoshinori Asou, Kenichi Shinomiya, Atsushi Okawa, Shu Takeda   +9 more
doaj   +1 more source

Case report of a lithopedion of tubal location, in a young woman

Radiology Case Reports, 2023
Lithopedion is a rare situation, corresponding to an ectopic pregnancy which evolves beyond the first trimester toward death and fetal calcification. This ectopic pregnancy is most often abdominal in location. Through this case report, we report the case
Coumba Gueye, MD, Ibrahima Niang, MD, Ousmane Sano, MD, Moustapha Toure, MD, Serigne Talla Faye, MD, Khaoulah Talhaoui, MD, Hamidou Deme, PhD   +6 more
doaj   +1 more source

Heart Valve Calcification

, 2021
This chapter focuses on the calcification of heart valves. The extent of valve calcification may vary from mild sclerosis with no effects on valve function to the development of leaflets calcification which causes valve dysfunction. It is well known that
Koulaouzidis, George,, Pompilio Faggiano, Henein, Michael,, Michael Henein, George Koulaouzidis, Faggiano, Pompilio,   +5 more
core   +1 more source

Inorganic pyrophosphate plasma levels in patients with GGCX-associated PXE-like phenotypes

Frontiers in Genetics
IntroductionPseudoxanthoma elasticum (PXE) is an autosomal recessive ectopic calcification disorder clinically affecting the skin, eyes, and vascular system.
Qiaoli Li, Qiaoli Li, Catherine Troutman, Mary Peckiconis, Tamara Wurst, Sharon F. Terry   +5 more
doaj   +1 more source

Liver-directed base editing of ABCC6 prevents ectopic calcification in a variant-humanized mouse model of pseudoxanthoma elasticum

Molecular Therapy: Nucleic Acids
Pseudoxanthoma elasticum (PXE) is an autosomal recessive connective tissue disorder characterized by ectopic calcification of elastic fibers throughout the skin, retina, and arteries.
Lauren C. Testa, Dora Obiri-Yeboah, Hooda Said, Ping Qu, Michael A. Levine, Mohamad-Gabriel Alameh, Kiran Musunuru, Qiaoli Li, Xiao Wang   +8 more
doaj   +1 more source

Converging Mechanisms of Vascular and Cartilaginous Calcification

Biology
Physiological calcification occurs in bones and epiphyseal cartilage as they grow, whereas ectopic calcification occurs in blood vessels, cartilage, and soft tissues.
Simona R. Gheorghe, Alexandra M. Crăciun, Tamás Ilyés, Ioana Badiu Tisa, Lucia Sur, Iulia Lupan, Gabriel Samasca, Ciprian N. Silaghi   +7 more
doaj   +1 more source

Deciphering Ectopic Calcification: Contribution of the Rare, Inherited Disorder Pseudoxanthoma Elasticum [PDF]

, 2015
Soft connective tissue calcification is still an intriguing problem due to the high number of genes, proteins, and enzymes involved in the process. Numerous epidemiological and experimental studies of the ectopic calcification associated with metabolic ...
Ivonne Pasquali Ronchetti
core