Results 11 to 20 of about 13,941 (262)
Evocalcet prevents ectopic calcification and parathyroid hyperplasia in rats with secondary hyperparathyroidism. [PDF]
PLoS ONE, 2020 BACKGROUND:Elevated parathyroid hormone (PTH) levels in secondary hyperparathyroidism (SHPT) lead to vascular calcification, which is associated with cardiovascular events and mortality.
Mariko Sakai +7 more
doaj +3 more sources
Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies [PDF]
International Journal of Molecular Sciences, 2023 Ectopic calcification refers to the pathological accumulation of calcium ions in soft tissues and is often the result of a dysregulated action or disrupted function of proteins involved in extracellular matrix mineralization.
João Miguel Almeida Santos +2 more
exaly +4 more sources
Hexasodium Fytate (SNF472 or CSL525) Inhibits Ectopic Calcification in Various Pseudoxanthoma Elasticum and Calcinosis Cutis Animal Models [PDF]
PharmaceuticalsBackground/Objectives: Ectopic calcification is a pathological condition characterized by the mineralization of soft tissues due to the deposition of calcium phosphate crystals.
Miguel D. Ferrer +11 more
doaj +4 more sources
Novel Treatments for PXE: Targeting the Systemic and Local Drivers of Ectopic Calcification [PDF]
International Journal of Molecular Sciences, 2023 Pseudoxanthoma elasticum (PXE) is a heritable multisystem ectopic calcification disorder. The gene responsible for PXE, ABCC6, encodes ABCC6, a hepatic efflux transporter regulating extracellular inorganic pyrophosphate (PPi), a potent endogenous ...
Qiaoli Li, Li Qiaoli
exaly +4 more sources
Future treatments for the arteriopathy of ectopic calcification disorders [PDF]
Frontiers in Drug Discovery, 2023 Ectopic calcification disorders, including Generalized Arterial Calcification of Infancy (GACI) and Pseudoxanthoma Elasticum are rare but impactful on individuals, healthcare and society, with significant associated morbidity, mortality and healthcare ...
Benjamin M. Davies +6 more
doaj +2 more sources
Minocycline Counteracts Ectopic Calcification in a Murine Model of Pseudoxanthoma Elasticum: A Proof-of-Concept Study [PDF]
International Journal of Molecular Sciences, 2022 Pseudoxanthoma elasticum (PXE) is an intractable Mendelian disease characterized by ectopic calcification in skin, eyes and blood vessels. Recently, increased activation of the DNA damage response (DDR) was shown to be involved in PXE pathogenesis, while
Lukas Nollet +2 more
exaly +3 more sources
Bone Reports, 2021 Equilibrative nucleoside transporter 1 (ENT1) transfers nucleosides, such as adenosine, across plasma membranes. We reported previously that mice lacking ENT1 (ENT1−/−) exhibit progressive ectopic calcification of spinal tissues—a phenotype resembling ...
Dale E. Fournier +5 more
doaj +2 more sources
Fetuin-a-based theranostics in ectopic calcification
, 2023 Published by RWTH Aachen University ...
Dzhanaev, Robert
openaire +4 more sources
Life, 2023 Visceral and ectopic fat accumulation might have an impact on the atherosclerotic calcification of abdominal arteries. The pattern of calcification of the abdominal aorta and its branches is not fully investigated.
Ivan Ordulj +7 more
doaj +2 more sources
Journal of Pharmacological Sciences, 2021 Since aortic valve stenosis (AVS) is the most frequent and serious valvular heart disease in the elderly, and is accompanied by irreversible valve calcification, medicinal prevention of AVS is important.
Xu Liu +8 more
doaj +2 more sources