Results 11 to 20 of about 139,269 (266)
The Role of Sclerostin in Bone and Ectopic Calcification [PDF]
International Journal of Molecular Sciences, 2020 Sclerostin, a 22-kDa glycoprotein that is mainly secreted by the osteocytes, is a soluble inhibitor of canonical Wnt signaling. Therefore, when present at increased concentrations, it leads to an increased bone resorption and decreased bone formation. Serum sclerostin levels are known to be increased in the elderly and in patients with chronic kidney ...
Anja Verhulst +2 more
exaly +8 more sources
Ectopic Calcification: What Do We Know and What Is the Way Forward? [PDF]
J Clin Med, 2023 Ectopic calcification, or ectopic mineralization, is a pathologic condition in which calcifications develop in soft tissues [...]
Snijders BMG, Peters MJL, Koek HL.
europepmc +6 more sources
Novel Treatments for PXE: Targeting the Systemic and Local Drivers of Ectopic Calcification [PDF]
International Journal of Molecular Sciences, 2023 Pseudoxanthoma elasticum (PXE) is a heritable multisystem ectopic calcification disorder. The gene responsible for PXE, ABCC6, encodes ABCC6, a hepatic efflux transporter regulating extracellular inorganic pyrophosphate (PPi), a potent endogenous ...
Qiaoli Li, Ida Joely Jacobs
exaly +4 more sources
ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions. [PDF]
Int J Mol Sci, 2021 Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic disorders. Pseudoxanthoma elasticum (PXE), a multi-organ disease affecting dermal, ocular, and cardiovascular tissues, is a model for ectopic mineralization disorders ...
Shimada BK +5 more
europepmc +5 more sources
Gitelman syndrome and ectopic calcification in the retina and joints. [PDF]
Clin Kidney J, 2021 Abstract Gitelman syndrome is a rare inherited renal tubular disorder with features that resemble thiazide use, including a hypokalemic metabolic alkalosis, hypomagnesemia, hypocalciuria and a low or normal blood pressure, hyperreninemia and hyperaldosteronism. Treatment is primarily correction of the potassium and magnesium levels.
Ham Y +4 more
europepmc +6 more sources
Future treatments for the arteriopathy of ectopic calcification disorders [PDF]
Frontiers in Drug Discovery, 2023 Ectopic calcification disorders, including Generalized Arterial Calcification of Infancy (GACI) and Pseudoxanthoma Elasticum are rare but impactful on individuals, healthcare and society, with significant associated morbidity, mortality and healthcare ...
Benjamin M. Davies +6 more
doaj +2 more sources
The role of sodium phosphate cotransporters in ectopic calcification [PDF]
Endokrynologia Polska, 2019 Phosphate plays a critical role in many vital cellular processes. Deviations from normal serum phosphate levels, including alterations in the extracellular phosphate/pyrophosphate ratio, can cause severe consequences, such as ectopic calcification. Cellular phosphate levels are tightly controlled by sodium phosphate cotransporters, underscoring their ...
Sergio, Gonzalo, Ricardo, Villa-Bellosta
openaire +4 more sources
Fetuin-a-based theranostics in ectopic calcification
, 2023 Published by RWTH Aachen University ...
Dzhanaev, Robert
openaire +4 more sources
Ectopic calcification in diabetic vascular disease
Expert Opinion on Therapeutic Targets, 2014 Cardiovascular diseases represent over one-half of all deaths in both type 1 and type 2 diabetes mellitus. In diabetic patients, vascular calcifications are more frequently observed than in people without diabetes. In particular, elevated degrees of coronary artery and valvular calcifications are reported in populations with diabetes.We will present ...
AVOGARO, ANGELO +2 more
openaire +4 more sources
KIF26B Silencing Prevents Osseous Transdifferentiation of Progenitor/Stem Cells and Attenuates Ectopic Calcification in a Murine Model [PDF]
Journal of Bone and Mineral Research, 2022 Matthew J Silva +2 more
exaly +2 more sources