Results 31 to 40 of about 178,374 (209)
Apoptosis in the Extraosseous Calcification Process
Cells, 2021 Extraosseous calcification is a pathologic mineralization process occurring in soft connective tissues (e.g., skin, vessels, tendons, and cartilage). It can take place on a genetic basis or as a consequence of acquired chronic diseases. In this last case,
Federica Boraldi +2 more
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Frontiers in Cardiovascular Medicine, 2023 Generalized arterial calcification of infancy (GACI) is a rare genetic disease characterized by arterial calcifications or stenoses and hypertension.
Pengtao Lu +6 more
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Pseudoxanthoma Elasticum as a Paradigm of Heritable Ectopic Mineralization Disorders: Pathomechanisms and Treatment Development. [PDF]
Am J Pathol, 2019 Ectopic mineralization is a global problem and leading cause of morbidity and mortality. The pathomechanisms of ectopic mineralization are poorly understood. Recent studies on heritable ectopic mineralization disorders with defined gene defects have been helpful in elucidation of the mechanisms of ectopic mineralization in general.
Li Q, van de Wetering K, Uitto J.
europepmc +3 more sources
Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI. [PDF]
J Invest Dermatol, 2019 Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic mineralization disorders, is caused by mutations in the ABCC6 gene encoding a putative efflux transporter ABCC6.
Li Q +7 more
europepmc +2 more sources
Zebrafish Models of Ectopic Mineralization—The Paradigm of Pseudoxanthoma Elasticum [PDF]
Journal of Investigative Dermatology, 2018 Zebrafish represent a powerful model system with which to study human biology and pathology. Recently developed CRISPR/Cas9 technology enables genetic manipulation with precision. Using CRISPR/Cas9 methodology, van Gils et al. generated knockout zebrafish for abcc6a, the orthologue of human ABCC6 that is mutated in pseudoxanthoma elasticum.
Qiaoli, Li, Jouni, Uitto
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Heritable Ectopic Mineralization Disorders: Pathomechanisms and Potential Treatment [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2018 Pseudoxanthoma elasticum (PXE), a prototype of heritable ectopic mineralization disorders, is an autosomal recessive disease characterized by deposition of calcium hydroxyapatite in the skin, eyes, and cardiovascular system, with protean manifestations (Li et al., 2016; Li and Uitto, 2013; Neldner, 1988).
Qiaoli, Li, Jouni, Uitto
openaire +2 more sources
Serum biomarkers for arterial calcification in humans: A systematic review
Bone Reports, 2022 Aim: To clarify the role of mediators of ectopic mineralization as biomarkers for arterial calcifications. Methods: MEDLINE and Embase were searched for relevant literature, until January 4th 2022.
Nienke M.S. Golüke +5 more
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Arthritis Research & Therapy, 2023 Background Ectopic ossification is an important cause of disability in patients with ankylosing spondylitis (AS). Whether fibroblasts can transdifferentiate into osteoblasts and contribute to ossification remains unknown.
Qianmei Jin +8 more
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The molecular and physiological roles of ABCC6: more than meets the eye
Frontiers in Genetics, 2012 Abnormal mineralization occurs in the context of several common conditions, including advanced age, diabetes, hypercholesterolemia, chronic renal failure and certain genetic conditions. Metabolic, mechanical, infectious, and inflammatory injuries promote
Olivier eLe Saux +5 more
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Frontiers in Cell and Developmental Biology, 2022 Chronic low back pain is a highly prevalent health condition intricately linked to intervertebral disc degeneration. One of the prominent features of disc degeneration that is commonly observed with aging is dystrophic calcification. ATP-binding cassette
Paige K. Boneski +5 more
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