Results 21 to 30 of about 183,658 (172)
Down-regulation of TGF-β1 in Fibro-adipogenic Progenitors Initiates Muscle Ectopic Mineralization
, 2023 Supplementary materials for article Down-regulation of TGF-β1 in Fibro-adipogenic Progenitors Initiates Muscle Ectopic Mineralization.
La Li (16998495)
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Zebrafish Models of Ectopic Mineralization—The Paradigm of Pseudoxanthoma Elasticum [PDF]
Journal of Investigative Dermatology, 2018 Zebrafish represent a powerful model system with which to study human biology and pathology. Recently developed CRISPR/Cas9 technology enables genetic manipulation with precision. Using CRISPR/Cas9 methodology, van Gils et al. generated knockout zebrafish for abcc6a, the orthologue of human ABCC6 that is mutated in pseudoxanthoma elasticum.
Qiaoli, Li, Jouni, Uitto
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Zebrafish Models to Study Ectopic Calcification and Calcium-Associated Pathologies [PDF]
, 2023 Ectopic calcification refers to the pathological accumulation of calcium ions in soft tissues and is often the result of a dysregulated action or disrupted function of proteins involved in extracellular matrix mineralization.
Paulo J. Gavaia +12 more
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Research Progress in Pseudoxanthoma Elasticum and Related Ectopic Mineralization Disorders [PDF]
Journal of Investigative Dermatology, 2016 Heritable ectopic mineralization disorders represent a phenotypically diverse group of conditions characterized by deposition of calcium phosphate complexes in soft connective tissues. The prototype of such conditions is pseudoxanthoma elasticum, and related conditions with overlapping clinical features include generalized arterial calcification of ...
Li, Qiaoli +4 more
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Mineral content of the maternal diet influences ectopic mineralization in offspring of Abcc6−/− mice [PDF]
Cell Cycle, 2015 Ectopic mineralization disorders inflicting the connective tissues display a spectrum of severity, some developing in utero and being diagnosed by prenatal ultrasound. This study was designed to test the hypothesis that the mineral content of maternal diet can influence the mineralization in the offspring.
Qiaoli, Li +2 more
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The molecular and physiological roles of ABCC6: more than meets the eye
Frontiers in Genetics, 2012 Abnormal mineralization occurs in the context of several common conditions, including advanced age, diabetes, hypercholesterolemia, chronic renal failure and certain genetic conditions. Metabolic, mechanical, infectious, and inflammatory injuries promote
Olivier eLe Saux +5 more
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Frontiers in Cell and Developmental Biology, 2022 Chronic low back pain is a highly prevalent health condition intricately linked to intervertebral disc degeneration. One of the prominent features of disc degeneration that is commonly observed with aging is dystrophic calcification. ATP-binding cassette
Paige K. Boneski +5 more
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Osteopontin Inhibits Mineral Deposition and Promotes Regression of Ectopic Calcification [PDF]
The American Journal of Pathology, 2002 Ectopic calcification, the abnormal calcification of soft tissues, can have severe clinical consequences especially when localized to vital organs such as heart valves, arteries, and kidneys. Recent observations suggest that ectopic calcification, like bone biomineralization, is an actively regulated process.
Susan A, Steitz +6 more
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Ectopic mineralization in fibroblast cultures.
Archivum histologicum japonicum, 1984 A human gingival fibroblast cell line was cultured in a DM-153 medium supplemented with 10% bovine serum. The cells in culture showed both intracellular and extracellular ectopic mineralization. Ultrastructurally, mineralization began within the round and irregularly shaped vesicles contained in large cytoplasmic vacuoles of fibroblasts.
KUMEGAWA, Masayoshi +2 more
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The diagnosis and management of ectopic pregnancy [PDF]
, 2006 The increase in the number of women in whom a diagnosis of ectopic pregnancy is made presents challenges to the gynaecologist. It is important to follow diagnostic protocols to ensure that cases are not missed.
Moore, Judith
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