Results 1 to 10 of about 188 (67)

Inflammation-Associated Ectopic Mineralization

Fundamental Research, 2023
Ectopic mineralization refers to the deposition of mineralized complexes in the extracellular matrix of soft tissues. Calcific aortic valve disease, vascular calcification, gallstones, kidney stones, and abnormal mineralization in arthritis are common ...
Yu-Xuan Ma, Li-Na Niu, Jing-Han Song
exaly   +3 more sources

Impact of the ENPP1 Mutation on Bone Mineralization and Ectopic Calcification: Evidence From in Vitro and in Vivo Models

Frontiers in Endocrinology
BackgroundEctonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) plays a key role in mineralization processes, and mutations in this gene are associated with various severe diseases.
Yingzhou Shi, Luna Liu, Wanhong Wu
exaly   +3 more sources

Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization

Advanced Science, 2022
Although deoxyribonucleic acid (DNA) is the genetic coding for the very essence of life, these macromolecules or components thereof are not necessarily lost after a cell dies.
Min‐juan Shen, Kai Jiao, Chen‐yu Wang, Hermann Ehrlich, Mei‐chen Wan, Dong‐xiao Hao, Jing Li, Qian‐qian Wan, Lige Tonggu, Jian‐fei Yan, Kai‐yan Wang, Yu‐xuan Ma, Ji‐hua Chen, Franklin R. Tay, Li‐na Niu   +14 more
doaj   +2 more sources

The Abcc6a Knockout Zebrafish Model as a Novel Tool for Drug Screening for Pseudoxanthoma Elasticum

Frontiers in Pharmacology, 2022
Pseudoxanthoma elasticum (PXE) is a multisystem ectopic mineralization disorder caused by pathogenic variants in the ABCC6 gene. Though complications of the disease can be treated, PXE itself remains currently intractable.
M. Van Gils, M. Van Gils, A. Willaert, A. Willaert, P. J. Coucke, P. J. Coucke, O. M. Vanakker, O. M. Vanakker   +7 more
doaj   +1 more source

Apoptosis in the Extraosseous Calcification Process

Cells, 2021
Extraosseous calcification is a pathologic mineralization process occurring in soft connective tissues (e.g., skin, vessels, tendons, and cartilage). It can take place on a genetic basis or as a consequence of acquired chronic diseases. In this last case,
Federica Boraldi, Francesco Demetrio Lofaro, Daniela Quaglino   +2 more
doaj   +1 more source

Case report: A rare homozygous variation in the ENPP1 gene, presenting with generalized arterial calcification of infancy in a Chinese infant

Frontiers in Cardiovascular Medicine, 2023
Generalized arterial calcification of infancy (GACI) is a rare genetic disease characterized by arterial calcifications or stenoses and hypertension.
Pengtao Lu, Jinglong Chen, Mei Chen, Ling Wang, Dandan Xiang, Jie Yin, Shiwei Yang   +6 more
doaj   +1 more source

Atherogenic Diet Accelerates Ectopic Mineralization in a Mouse Model of Pseudoxanthoma Elasticum

International Journal of Dermatology and Venerology, 2020
. Objective:. Pseudoxanthoma elasticum (PXE) is a multisystem heritable disorder caused by mutations in the Abcc6 gene. The disease is characterized by ectopic mineralization of the skin, eyes, and arterial blood vessels. Previous studies have suggested
Jing-Yi Zhao, Joshua Kingman, Ida Joely Jacobs, Jouni Uitto, Yi Cao, Qiao-Li Li   +5 more
doaj   +1 more source

Serum biomarkers for arterial calcification in humans: A systematic review

Bone Reports, 2022
Aim: To clarify the role of mediators of ectopic mineralization as biomarkers for arterial calcifications. Methods: MEDLINE and Embase were searched for relevant literature, until January 4th 2022.
Nienke M.S. Golüke, Marit A. Schoffelmeer, Annemarieke De Jonghe, Mariëlle H. Emmelot-Vonk, Pim A. De Jong, Huiberdina L. Koek   +5 more
doaj   +1 more source

MYC promotes fibroblast osteogenesis by regulating ALP and BMP2 to participate in ectopic ossification of ankylosing spondylitis

Arthritis Research & Therapy, 2023
Background Ectopic ossification is an important cause of disability in patients with ankylosing spondylitis (AS). Whether fibroblasts can transdifferentiate into osteoblasts and contribute to ossification remains unknown.
Qianmei Jin, Yaoyang Liu, Zhiguo Zhang, Xingzhu Wen, Ziqiang Chen, Haijun Tian, Zijian Kang, Xin Wu, Huji Xu   +8 more
doaj   +1 more source

Mouse models for pseudoxanthoma elasticum: genetic and dietary modulation of the ectopic mineralization phenotypes.

PLoS ONE, 2014
Pseudoxanthoma elasticum (PXE), a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene. Null mice (Abcc6(-/-) ) recapitulate the genetic, histopathologic and ultrastructural features of PXE, and they demonstrate early and ...
Qiaoli Li, Haitao Guo, David W Chou, Annerose Berndt, John P Sundberg, Jouni Uitto   +5 more
doaj   +1 more source