Inflammation-associated ectopic mineralization [PDF]
Fundamental Research, 2023 Ectopic mineralization refers to the deposition of mineralized complexes in the extracellular matrix of soft tissues. Calcific aortic valve disease, vascular calcification, gallstones, kidney stones, and abnormal mineralization in arthritis are common ...
Lina Niu
exaly +7 more sources
FAM20A Gene Mutation: Amelogenesis or Ectopic Mineralization? [PDF]
Frontiers in Physiology, 2017 Background and objective:FAM20A gene mutations result in enamel renal syndrome (ERS) associated with amelogenesis imperfecta (AI), nephrocalcinosis, gingival fibromatosis, and impaired tooth eruption.
Guilhem Lignon +10 more
doaj +7 more sources
Extracellular DNA: A Missing Link in the Pathogenesis of Ectopic Mineralization [PDF]
Advanced Science, 2022 Although deoxyribonucleic acid (DNA) is the genetic coding for the very essence of life, these macromolecules or components thereof are not necessarily lost after a cell dies.
Min‐juan Shen +14 more
doaj +7 more sources
Genetic heterogeneity of heritable ectopic mineralization disorders in a large international cohort [PDF]
Genetics in Medicine, 2022 Heritable ectopic mineralization disorders comprise a group of conditions with a broad range of clinical manifestations in nonskeletal connective tissues. We report the genetic findings from a large international cohort of 478 patients afflicted with ectopic mineralization.Sequence variations were identified using a next-generation sequencing panel ...
Adam E Snook +2 more
exaly +6 more sources
Atherogenic Diet Accelerates Ectopic Mineralization in a Mouse Model of Pseudoxanthoma Elasticum [PDF]
International Journal of Dermatology and Venerology, 2020 . Objective:. Pseudoxanthoma elasticum (PXE) is a multisystem heritable disorder caused by mutations in the Abcc6 gene. The disease is characterized by ectopic mineralization of the skin, eyes, and arterial blood vessels. Previous studies have suggested
Jing-Yi Zhao +5 more
doaj +4 more sources
HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization. [PDF]
PLoS ONE, 2016 Numerous clinical conditions have been linked to ectopic mineralization (EM). This process of pathological biomineralization is complex and not fully elucidated, but thought to be started within matrix vesicles (MVs).
Qiang Chen +8 more
doaj +5 more sources
The Role of Vitamin K and Its Related Compounds in Mendelian and Acquired Ectopic Mineralization Disorders [PDF]
International Journal of Molecular Sciences, 2019 Ectopic mineralization disorders comprise a broad spectrum of inherited or acquired diseases characterized by aberrant deposition of calcium crystals in multiple organs, such as the skin, eyes, kidneys, and blood vessels.
Shana Verschuere +2 more
exaly +5 more sources
Editorial: Ectopic Mineralization of Tissues: Mechanisms, Risk Factors, Diseases, and Prevention [PDF]
Frontiers in Cell and Developmental Biology, 2021 Hervé Kempf +5 more
doaj +5 more sources
Frontiers in EndocrinologyBackgroundEctonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) plays a key role in mineralization processes, and mutations in this gene are associated with various severe diseases.
Luna Liu
exaly +3 more sources
The liver regulates ectopic calcification in Abcc6-deficient models of pseudoxanthoma elasticum [PDF]
The Journal of Clinical InvestigationPseudoxanthoma Elasticum (PXE) is a rare disease caused by loss of function of the ATP-binding cassette C (ABC) member 6 (Abcc6) gene and characterized by ectopic calcification of multiple tissues, but the physiological reasons underlying ectopic ...
Yijie Wang +19 more
doaj +2 more sources