Ectopic implantation of juvenile osteochondral tissues recapitulates endochondral ossification [PDF]
Journal of Tissue Engineering and Regenerative Medicine, 2017 Subcutaneous implantation in a mouse can be used to investigate tissue maturation in vivo. Here we demonstrate that this simple model can recapitulate endochondral ossification associated with native skeletal development. By histological and micro-computed tomography analysis we investigated morphological changes of immature bovine osteochondral ...
Johnathan Ng +6 more
openaire +2 more sources
Recommendations for Diagnosis and Treatment of Pseudohypoparathyroidism and Related Disorders : An Updated Practical Tool for Physicians and Patients [PDF]
, 2020 Patients affected by pseudohypoparathyroidism (PHP) or related disorders are characterized by physical findings that may include brachydactyly, a short stature, a stocky build, early-onset obesity, ectopic ossifications, and neurodevelopmental deficits ...
Á +55 more
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Multiple osteochondromas of the antlers and cranium in a free-ranging white-tailed deer (Odocoileus virginianus) [PDF]
, 2017 This paper reports a case of multiple osteochondromas affecting the antlers and the left zygomatic bone of a free-ranging adult white-tailed buck (Odocoileus virginianus) from Georgia, USA.
Flohr, Stefan +4 more
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Advanced Healthcare Materials, EarlyView.This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister +14 more
wiley +1 more source
Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration
Advanced Science, EarlyView.Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman +5 more
wiley +1 more source
ECTOPIC OSSIFICATION FOLLOWING TOTAL HIP ARTHROPLASTY: IS DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS A RISK FACTOR? [PDF]
, 2017 Total hip a≪hroplasty may be followed by ectopic bone formation. An increased frequency has been suspected in patients with diffuse idiopathic skeletal hypcrostosis (DISH).
BALLMER, P. +4 more
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Postoperative Exostosis: Ectopic Ossification After Pericardial Window Procedure
Annals of Thoracic Surgery Short Reports, 2023 A 58-year-old Hispanic man had persistent epigastric pain after pericardial window procedure for viral pericarditis several years earlier. After review of a computed tomography scan, a calcified epigastric subcutaneous mass was detected. The patient elected to undergo surgical excision of the mass, which revealed a heterotopic ossified lesion arising ...
Ahmed Mostafa +3 more
openaire +1 more source
Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction
Advanced Science, EarlyView.We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang +9 more
wiley +1 more source
Long-term outcome after traumatic anterior dislocation of the hip [PDF]
, 2018 Introduction: Traumatic anterior dislocation of the hip joint is rare. Additional injuries to the hip due to dislocation are even more infrequent. Outcome is limited by osteoarthritic joint degeneration or the occurrence of avascular necrosis of the ...
Bastian, Johannes +3 more
core
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source