Results 171 to 180 of about 199,968 (239)

A case of jejunal cancer arising from ectopic pancreas. [PDF]

open access: yesClin J Gastroenterol
Eizuka M   +9 more
europepmc   +1 more source

A rare case of adenocarcinoma of an ectopic pancreas: A case report. [PDF]

open access: yesInt J Surg Case Rep, 2022
Manhal K   +3 more
europepmc   +1 more source

RUNX1‐Driven CPXM1 Transcription Promotes Malignant Phenotypes and EMT in Gastric Cancer Cells

open access: yesCancer Science, Volume 117, Issue 11, Page 2938-2952, November 2026.
RUNX1 transcriptionally activates CPXM1, promotes EMT, and enhances the proliferation, invasion, and metastasis of gastric cancer cells. ABSTRACT Gastric cancer (GC) remains a leading cause of cancer‐related mortality worldwide, with current treatment strategies largely limited to surgery, chemotherapy, and targeted therapy.
Ping Jia   +8 more
wiley   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

open access: yesCancer Science, Volume 117, Issue 11, Page 2910-2923, November 2026.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang   +6 more
wiley   +1 more source

Efficacy and Safety of SGLT2 Inhibitors in Patients With Genetic Lipodystrophy: A Real‐Life Experience From a National Reference Network

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10318-10329, November 2026.
ABSTRACT Aim Lipodystrophy syndromes are rare diseases with metabolic and cardiovascular consequences. This study explores the metabolic and renal effects of sodium‐glucose cotransporter 2 inhibitors (SGLT2i) in patients with genetic lipodystrophy. Patients and Methods Patients with familial partial lipodystrophy (n = 57) or congenital generalised ...
Léna Robert   +12 more
wiley   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

open access: yesImmunology, Volume 179, Issue 3, Page 337-349, November 2026.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos   +5 more
wiley   +1 more source

Mitochondrial Dysfunction as a Context‐Dependent Driver and Amplifier of the SASP: Targeting the mtDNA–cGAS–STING Axis for Next‐Generation Senotherapeutics

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT Cellular senescence combines stable cell‐cycle arrest with mitochondrial and innate immune remodelling that shapes the senescence‐associated secretory phenotype (SASP). This narrative review evaluates mitochondrial dysfunction as a context‐dependent initiator or amplifier of senescence and examines mitochondrial DNA (mtDNA) sensing through ...
Hamza Kamaran Hama   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy