Results 101 to 110 of about 13,380 (189)

Eculizumab Therapy [PDF]

Biology of Blood and Marrow Transplantation, 2014
openaire   +2 more sources

The use of eculizumab in renal transplantation

, 2013
The complement system plays a vital role in mediating disease processes within renal allografts. Eculizumab is a humanized monoclonal antibody that targets complement protein C5, inhibiting cleavage into C5a and C5b, and therefore preventing formation of
Dorling, Anthony; id_orcid, Sacks, Steven H; id_orcid, Chowdhury, Paramit, Barnett, A Nicholas R, Asgari, Elham, Mamode, Nizam   +5 more
core   +1 more source

Life-threatening pregnancy-associated atypical haemolytic uraemic syndrome and its response to eculizumab

, 2017
Pregnancy-associated atypical haemolytic uraemic syndrome (P-aHUS) is a rare, potentially lethal condition that can complicate pregnancy in up to 1 in 25 000 cases. Without prompt diagnosis and initiation of appropriate treatment, this condition can lead
Kurtkoti, Jagadeesh, Aye San, Gately, Ryan, Alan Parnham, Parnham, Alan, Ryan Gately, San, Aye, Jagadeesh Kurtkoti   +7 more
core   +1 more source

Eculizumab or ravulizumab treatment effect in people with neuromyelitis optica spectrum disorder: a plain language summary of three studies

Journal of Comparative Effectiveness Research
What is this summary about? Neuromyelitis optica spectrum disorder (NMOSD for short) is a rare autoimmune health condition, meaning that the body’s natural defense system (the immune system) attacks the body’s own tissues.
Alfredo Damasceno, Mariano Marrodan
doaj   +1 more source

Successful Treatment of Posttransplant Recurrent Complement C3 Glomerulopathy with Eculizumab

, 2018
Two-thirds of complement C3 glomerulopathy (C3G) recur after transplantation and commonly cause graft loss. There is not a standard treatment protocol for these cases. We present a kidney transplant patient with recurrent C3G who was successfully treated
Atilgan, Gokhan, Ayli, Mehmet Deniz, Okyay, Gulay Ulusal, Akoglu, Hadim, Oguz, Ebru Gok, Gursoy, Guner Karaveli, Teymur, Tugba Kip, Sahin, Hatice, Canbakan, Basol, Ertoy, Dilek   +9 more
core  

Reduced dose maintenance eculizumab in atypical hemolytic uremic syndrome (aHUS): an update on a previous case report

Clinical Pharmacology: Advances and Applications, 2011
Maro Ohanian, Christian Cable, Kathleen Halka Department of Hematology/Oncology, Scott & White Healthcare and The Texas A&M Health Science Center, College of Medicine, Temple, TX, USA Objective: To describe how maintenance eculizumab ...
Halka K, Cable C, Ohanian M
doaj  

Disseminated cryptococcosis associated with administration of eculizumab.

, 2018
PURPOSE: A case report of fatal disseminated cryptococcosis in a patient treated with eculizumab is presented along with a review of literature suggesting a possible etiologic mechanism.
Iaderosa, Roberto, McGhan, Ryan, Aldrich, Christina, Gitomer, Jeremy, Stevens, Ryan, Clancy, Megan, Inocencio, Ana Marie   +6 more
core  

Astrocytic and Axonal Injury Biomarkers in AQP4 Antibody-Positive NMOSD: Insights From PREVENT and CHAMPION-NMOSD. [PDF]

Neurol Neuroimmunol Neuroinflamm
Wingerchuk DM, Bennett JL, Berthele A, Clardy SL, Kim HJ, Nakahara J, de Sèze J, Kinoshita M, Sharma B, Uchida CL, Deeb Bou-Chahine R, Parks B, Allen K, Stankowski JN, Pittock SJ.   +14 more
europepmc   +1 more source

Complement C5 inhibitor as a rescue therapy for acute NMOSD attacks: a multicenter retrospective cohort study in China. [PDF]

Front Immunol
Wu T, Tian D, Huang D, Wu L, Zhen J, Yin J, Guo J, Jiang J, Li F, Jin H, Zheng Y, Wang Z, Liu R, Gao F.   +13 more
europepmc   +1 more source

Case Report: A young female with co-morbid SLE and atypical hemolytic uremic syndrome carrying <i>IRF5</i> risk variants. [PDF]

Front Immunol
Zhou H, Liu W, Sun T, Zhang L, Sun W, Wang W.   +5 more
europepmc   +1 more source