Results 81 to 90 of about 11,886 (196)
The Complement System in Post‐Transplant Kidney Injury
Organ Medicine, EarlyView.
Mengsi Hu
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta +2 more
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Patients receiving Eculizumab (Soliris\uae) at high risk for invasive meningococcal disease despite vaccination [PDF]
July 7, 2017, 11:00 ET (11:00 AM ET)CDCHAN-00404Summary: Eculizumab (Soliris\uae) recipients have a 1,000 to 2,000-fold greater risk of invasive meningococcal disease compared to the general U.S. population.
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Hemolysis in eculizumab-treated PNH patients [PDF]
, 2017 35 p.-3 fig.-4 tab. Subías, Marta et al.Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia characterized by complement-mediated intravascular hemolysis that is effectively treated with eculizumab. However, treatment responses are
Anter, Jaouad +5 more
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Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD
Annals of Clinical and Translational Neurology, Volume 13, Issue 7, Page 1488-1492, July 2026.ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6 ...
Sean J. Pittock +4 more
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Critical appraisal of eculizumab for atypical hemolytic uremic syndrome [PDF]
, 2016 Lilian M Pereira Palma,1 Craig B Langman2 1Pediatric Nephrology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil; 2The Feinberg School of Medicine, Northwestern University, and the Ann and Robert H.
Palma LMP, Langman CB
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Clinical Case Reports, Volume 14, Issue 7, July 2026.ABSTRACT Area postrema syndrome (APS) is a rare neurological syndrome that presents a significant diagnostic challenge due to its nonspecific clinical manifestations, most commonly persistent nausea and vomiting, which frequently lead to initial misdiagnosis as a gastrointestinal disorder.
Andreea‐Gabriela Manole +4 more
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Clinical Case Reports, Volume 14, Issue 7, July 2026.ABSTRACT Clinically suspected invasive meningococcal disease can deteriorate rapidly in previously well children. Prompt recognition of the petechial–purpuric rash with shock, early empirical antibiotics, and aggressive supportive pediatric intensive care are cornerstones of management as multiorgan dysfunction and Acute Respiratory Distress Syndrome ...
Shatha Omar +6 more
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Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab [PDF]
, 2019 Eculizumab is the first drug approved for the treatment of complement-mediated diseases, and current dosage schedules result in large interindividual drug concentrations.
Wetzels, J.F.M. +23 more
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