Results 41 to 50 of about 15,580 (252)
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
Advanced Healthcare Materials, EarlyView.This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa +4 morewiley +1 more sourceSonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis
Advanced Science, EarlyView.Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin +11 morewiley +1 more sourcePharmacokinetics, efficacy and safety of dupilumab administered with prefilled pen devices in patients aged <12 years with atopic dermatitis
British Journal of Clinical Pharmacology, EarlyView.Aim
For children with atopic dermatitis (AD), dupilumab is available as a prefilled syringe (PFS) from the age of 6 months and as a prefilled pen (PFP) for patients aged ≥2 years, in 200‐ and 300‐mg devices. This substudy of an ongoing open‐label extension study evaluated the pharmacokinetics, efficacy and safety of switching from a dupilumab PFS ...Amy S. Paller, Elaine C. Siegfried, Ashish Bansal, Jing Xiao, Faisal A. Khokhar, Michael Van Spall, Xia Liu, Christine Xu, Ariane Dubost‐Brama, Matthew P. Kosloski +9 morewiley +1 more sourceChronic conditions associated with paediatric onset inflammatory bowel diseases: A population‐based study
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objective
Several conditions are associated with inflammatory bowel disease (IBD), including immune‐mediated inflammatory diseases (IMIDs), extraintestinal manifestations (EIMs), and psychiatric disorders. This study aimed to describe at population‐level the comorbidities and their relative burden in paediatric‐onset IBD (pIBD).Nicolas Richard, Ariane Leroyer, Hélène Sarter, Claire Dupont, Dominique Turck, Valérie Bertrand, Pauline Wils, Corinne Gower‐Rousseau, Guillaume Savoye, Nathalie Guillon, Delphine Ley, Mathurin Fumery, EPIMAD Study Group, R. Al Hameedi, M. Al Khatib, S. Al Turk, E. Agoute, J.M. Andre, M. Antonietti, A. Aouakli, A. Armand, L. Armengol‐Debeir, I. Aroichane, F. Assi, J.P. Aubet, E. Auxenfants, A. Avram, F. Ayafi‐Ramelot, K. Azzouzi, D. Bankovski, B. Barbry, N. Bardoux, P. Baron, A. Baudet, P. Bayart, B. Bazin, A. Bebahani, J.P. Becqwort, S. Bellati, V. Benet, H. Benali, C. Benard, C. Benguigui, E. Ben Soussan, A. Bental, I. Berkelmans, J. Bernet, K. Bernou, C. Bernou‐Dron, P. Bertot, N. Bertiaux‐Vandaële, V. Bertrand, E. Billoud, N. Biron, B. Bismuth, M. Bleuet, F. Blondel, V. Blondin, M. Bobula, P. Bohon, V. Bondjemah, E. Boniface, D. Bonkovski, P. Bonnière, E. Bonvarlet, P. Bonvarlet, A. Boruchowicz, R. Bostvironnois, M. Boualit, A. Bouazza, B. Bouche, C. Boudaillez, C. Bourgeaux, M. Bourgeois, A. Bourguet, A. Bourienne, H. Boutaleb, A. Bouthors, J. Branche, G. Bray, F. Brazier, P. Breban, M. Bridenne, H. Brihier, L. Bril, V. Brung‐Lefebvre, P. Bulois, P. Burgiere, J. Butel, J.Y. Canva, V. Canva‐Delcambre, J.P. Capron, F. Cardot, S. Carette, P. Carpentier, E. Cartier, J.F. Cassar, M. Cassagnou, J.F. Castex, P. Catala, S. Cattan, S. Catteau, B. Caujolle, G. Cayron, C. Chandelier, M. Chantre, J. Charles, T. Charneau, M. Chavance‐Thelu, A. Cheny, D. Chirita, A. Choteau, J.F. Claerbout, P.Y. Clergue, H. Coevoet, G. Cohen, R. Collet, M. Colin, J.F. Colombel, S. Coopman, L. Cordiez, J. Corvisart, A. Cortot, F. Couttenier, J.F. Crinquette, V. Crombe, I. Dadamessi, H. Daoudi, V. Dapvril, T. Davion, S. Dautreme, J. Debas, S. Decoster, N. Degrave, F. Dehont, C. Delatre, R. Delcenserie, D. Delesalle, O. Delette, T. Delgrange, L. Delhoustal, J.S. Delmotte, S. Demmane, G. Deregnaucourt, P. Descombes, J.P. Desechalliers, P. Desmet, P. Desreumaux, G. Desseaux, P. Desurmont, A. Devienne, E. Devouge, M. Devred, A. Devroux, A. Dewailly, S. Dharancy, A. Di Fiore, D. Djedir, R. Djedir, W. Doleh, Ml. Dreher‐Duwat, R. Dubois, C. Duburque, P. Ducatillon, J. Duclay, B. Ducrocq, F. Ducrot, P. Ducrotte, A. Dufilho, C. Duhamel, D. Dujardin, C. Dumant‐Forest, J.L. Dupas, F. Dupont, Y. Duranton, A. Duriez, N. Duveau, K. El Achkar, M. El Farisi, C. Elie, M.C. Elie‐Legrand, A. Elkhaki, M. Eoche, E. Essmaeel, D. Evrard, J.P. Evrard, A. Fatome, B. Filoche, L. Finet, M. Flahaut, C. Flamme, D. Foissey, P. Fournier, Mc. Foutrein‐ Comes, P. Foutrein, D. Fremond, T. Frere, M. Fumery, P. Gallais, C. Gamblin, S. Ganga, R. Gerard, G. Geslin, Y. Gheyssens, N. Ghossini, S. Ghrib, T Gilbert, B. Gillet, D. Godart, P. Godard, J.M. Godchaux, R. Godchaux, G. Goegebeur, O. Goria, F. Gottrand, P. Gower, B. Grandmaison, M. Groux, C. Guedon, L. Guerbeau, M. Gueroult‐Dero, J.F. Guillard, L. Guillem, F. Guillemot, D. Guimberd, B. Haddouche, S. Hakim, D. Hanon, V. Hautefeuille, P. Heckestweiller, G. Hecquet, J.P. Hedde, H. Hellal, P.E. Henneresse, B. Heyman, M. Heraud, S. Herve, P. Hochain, L. Houssin‐Bailly, P. Houcke, B. Huguenin, S. Iobagiu, S. Istanboli, A. Ivanovic, I. Iwanicki‐Caron, E. Janicki, M. Jarry, J. Jeu, Jp. Joly, C. Jonas, A. Jouvenet, F. Katherin, A. Kerleveo, A. Khachfe, A. Kiriakos, J. Kiriakos, O. Klein, M. Kohut, R. Kornhauser, D. Koutsomanis, Je. Laberenne, E. Lacotte, G. Laffineur, M. Lagarde, A. Lalanne, A. Lalieu, P. Lannoy, J. Lapchin, M. Laprand, D. Laude, R. Leblanc, P. Lecieux, S. Lecleire, N. Leclerc, C. Le Couteulx, J. Ledent, J. Lefebvre, P. Lefiliatre, C. Le Goffic, C. Legrand, A. Le Grix, P. Lelong, B. Leluyer, C. Lemaitre, C. Lenaerts, G. Lepeut, L. Lepileur, A. Leplat, E. Lepoutre‐Dujardin, H. Leroi, M.Y. Leroy, P. Le Roy, B. Lesage, Jp. Lesage, X. Lesage, J. Lesage, I. Lescanne‐Darchis, J. Lescut, D. Lescut, B. Leurent, P. Levy, M. Lhermie, L. Libier, A. Lion, B. Lisambert, I. Loge, F. Loire, J. Loreau, S. Louf, A. Louvet, L. Lubret, M. Luciani, D. Lucidarme, J. Lugand, O. Macaigne, D. Maetz, D. Maillard, H. Mancheron, O. Manolache, Ab. Marks‐Brunel, C. Marre, R. Marti, F. Martin, G. Martin, E. Marzloff, P. Mathurin, J. Mauillon, V. Maunoury, J.L. Maupas, Ma. Medam Djomo, C. Mechior, Z. Melki, B. Mesnard, P. Metayer, L. Methari, B. Meurisse, F. Meurisse, L. Michaud, X. Mirmaran, P. Modaine, A. Monthe, L. Morel, P.E. Mortier, E. Moulin, O. Mouterde, N. Mozziconaci, J. Mudry, M. Nachury, Md. Ngo, E. N'Guyen Khac, B. Notteghem, V. Ollevier, A. Ostyn, A. Ouraghi, B. Oussadou, D. Ouvry, B. Paillot, C. Painchart, N. Panien‐Claudot, C. Paoletti, A. Papazian, B. Parent, B. Pariente, Jc. Paris, P. Patrier, T. Paupard, B. Pauwels, M. Pauwels, E. Penninck, R. Petit, M. Piat, S. Piotte, C. Plane, B. Plouvier, E. Pollet, P. Pommelet, D. Pop, C. Pordes, G. Pouchain, P. Prades, A. Prevost, Jc. Prevost, G. Quartier, B. Quesnel, A.M. Queuniet, Jf. Quinton, A. Rabache, P. Rabelle, G. Raclot, S. Ratajczyk, D. Rault, V. Razemon, N. Reix, T. Renaut‐Vantroys, M. Revillion, G. Riachi, C. Richez, P. Robinson, J. Rodriguez, J. Roger, J.M. Roux, A. Rudelli, A. Saber, G. Savoye, P. Schlossberg, D. Sefrioui, M. Segrestin, D. Seguy, C. Seminur, M. Serin, A. Seryer, F. Sevenet, N. Shekh, J. Silvie, V. Simon, C. Spyckerelle, N. Talbodec, N. Tavernier, H. Tchandeu, A. Techy, J.L. Thelu, A. Thevenin, H. Thiebault, J. Thomas, J.M. Thorel, C. Thuillier, G. Tielman, M. Tode, J. Toisin, J. Tonnel, Jy. Touchais, P. Toumelin, Y. Touze, J.L. Tranvouez, C. Triplet, N. Triki, D. Turck, S. Uhlen, E. Vaillant, C. Valmage, D. Vanco, N. Vandaele‐Bertiaux, H. Vandamme, E. Vanderbecq, E. Vander Eecken, P. Vandermolen, P. Vandevenne, L. Vandeville, A. Vandewalle, C. Vandewalle, P. Vaneslander, J.P. Vanhoove, A. Vanrenterghem, C. Vanveuren, P. Varlet, I. Vasies, G. Verbiese, J. Verlynde, G. Vernier‐Massouille, P. Vermelle, C. Verne, P. Vezilier‐Cocq, B. Vigneron, M. Vincendet, J. Viot, Y.M. Voiment, A. Wacrenier, L. Waeghemaecker, J.Y. Wallez, M. Wantiez, F. Wartel, J. Weber, J.L. Willocquet, N. Wizla, E. Wolschies, O. Zaharia, S. Zaoui, A. Zalar, B. Zaouri, A. Zellweger, C. Ziade +480 morewiley +1 more sourceReport from the fourth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative) [PDF]
, 2016 This article is a report of the fourth meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in Malmö, Sweden on 23–24 April 2015 (HOME IV).Graff, A. L. B., Smirnova, J., Williams, H.C., Wahlgren, C. -F, Chalmers, J R, Leshem, Y. A.,, Sulzer, A.,, Spuls, P. I.,, Aoki, V.,, Mizutani, H, Synnøve Gjerde, E.,, Wollenberg, A., Synnøve Gjerde, E, Burton, T, Murrell, D F, Graff, A. L. B.,, Chalmers, J. R.,, Murota, H, Apfelbacher, C J, Schuttelaar, M. L A, Drucker, A., Massuel, M. A., Drucker, A.,, Takaoka, R.,, Svensson, Åke,, Svensson, Å., Shindo, S., Svensson, Åke, Simpson, E., Nograles, K, Prinsen, C.,, Bragg, A., Flohr, C.,, Williams, H C, Weidinger, S, Chalmers, J.R., Ohya, Y., Spuls, P.I., Creswell-Melville, A., Thomas, K S, Aoki, V, Takaoka, R, Pander, J., Osterloh, I, on behalf of the long-term control of eczema working group for the HOME initiative, Zhao, C.Y., Schmitt, J, Marquort, B., Chalmers, J. R., Nograles, K., Schuttelaar, Marie L. A., Ohya, Y, Merhand, S.,, Simpson, E, Mizutani, H., Hanifin, J.,, von Kobyletzki, L., Spuls, P. I., Ridd, M.,, Ishii, H A, Ridd, M, Abuabara, K., Schuttelaar, M. L A,, Yamaga, K, Schuttelaar, M. -L. A.; id_orcid, Massuel, M. -A, Eckert, L., Awici-Rasmussen, M.,, Schuttelaar, M.-L. A., Thomas, K. S.,, Pander, Jan, Gerbens, L A A, Singh, J. A., Weidinger, S., Prinsen, C., Nasr, I, Simpson, Elizabeth M, Bjerring Clemmensen, K K, Wollenberg, A.,, Synnøve Gjerde, E., Ishii, H.A., Nakahara, T.,, Creswell-Melville, A, Ohya, Y.,, Dinesen, M, Thomas, K.S., Weisshaar, Elke, Bjerring Clemmensen, K. K.,, Graff, A.L.B., Heinl, D., Gjerde, E. Synnove, Torchet, F.,, Zhao, C. Y., Tauber, M., Shindo, S.,, Sulzer, A., Schmitt, J., Apfelbacher, C. J., Wahlgren, C. -F., Singh, J A, Wahlgren, C-F, Purkins, L., Williams, H. C.,, Berents, T.L., Vestby Talmo, H., von Kobyletzki, L, Schuttelaar, M. -LA., Kataoka, Y., Sach, T.,, Block, J., Graff, A. L B, Massuel, M. A.,, Kobyletzki, L., Sulzer, A, Ardeleanu, M.,, Sach, T, Bragg, A, Awici-Rasmussen, M, Wollenberg, A, von Kobyletzki, L.,, Torchet, F., Smirnova, J.,, Heinl, D, Schuttelaar, M-L A, Nograles, K.,, Volke, A.,, Hanifin, J., Ardeleanu, M, Svensson, Å, Gerbens, L. A. A., Tauber, M.,, Awici‐Rasmussen, M., Clemmensen, K. K. Bjerring, Flohr, C., Nakahara, T., Tauber, M, Eckert, L.,, Svensson, A.,, Massuel, M. -A., Yamaga, K.,, Heinl, D.,, Awici-Rasmussen, M., Wahlgren, C. F., Zhao, Z. Y., Leshem, Y. A., Vestby Talmo, H.,, Nakahara, T, Schmitt, J.,, Gerbens, L.A.A., Humphreys, R., Pander, J.,, Talmo, H. Vestby,, Bjerring Clemmensen, K.K., Gerbens, L. A. A.,, Leshem, Y.A., Ardeleanu, M., Hanifin, J, Merhand, S, Humphreys, R, Ishii, H. A., Volke, A, Burton, T., Svensson, Staffan, Lund University., Barbarot, S., Bragg, A.,, Ridd, M., Bjerring Clemmensen, K. K., Spuls, P I, Aoki, V., Prinsen, C, Kataoka, Y, Flohr, C, Murota, H., Leshem, Y A, Sach, T., Shindo, S, Purkins, L.,, Osterloh, I.,, Abuabara, K, Purkins, L, Merhand, S., Pander, J, Massuel, M.-A., Flohr, Carsten, Apfelbacher, C. J.,, Vestby Talmo, H, Schuttelaar, Marie-Louise A, Osterloh, I., Hanifin, Jon M, Weisshaar, E., Apfelbacher, C.J., Marquort, B, Gjerde, E. Synnove,, Yamaga, K., Murrell, D. F., Barbarot, S, Garg, M.,, Nasr, I., Garg, M, Berents, T L, Singh, J. A.,, Humphreys, R. D., Kataoka, Y.,, Eckert, L, Gerbens, L. A A, Massuel, M.‐A., Creswell-Melville, A.,, Talmo, H. Vestby, Weisshaar, E.,, Mizutani, H.,, Dinesen, M.,, Dinesen, M., Thomas, K. S., Takaoka, R., Gerbens, L. A A,, Volke, A., Singh, J.A., Zhao, C. Y.,, Torchet, F, Berents, T. L.,, Wahlgren, C.‐F., Ishii, H. A.,, von Kobyletzki, Laura B.,, Wahlgren, C.-F., Williams, H. C., Weidinger, S.,, Singh, Jasvinder A, Block, J.,, Simpson, E.,, Clemmensen, K. K. Bjerring,, Wahlgren, C. F.,, Abuabara, K.,, Graff, A. L B,, Graff, A L B, Barbarot, S.,, Weisshaar, E, Garg, M., Massuel, M-A, Murrell, D. F.,, Murrell, D.F., Creswell‐Melville, A., Schuttelaar, M. -L. A., Smirnova, J, Zhao, C Y, Murota, H.,, Berents, T. L., Humphreys, R.,, Block, J, Drucker, A, Svensson, Graff, A. L.B., Singh, JA, Flohr, C.; id_orcid, von, Kobyletzki L, Gerbens, L. A.A., Williams, HC, Chalmers, JR, Thomas, KS, Schuttelaar, M. L.A., Apfelbacher, CJ +260 morecore +2 more sourcesDupilumab Provides Rapid and Sustained Clinically Meaningful Responses in Adults with Moderate-to-severe Atopic Dermatitis
Acta Dermato-Venereologica, 2021 Optimal management of atopic dermatitis requires a comprehensive assessment of response to treatment in order to inform therapeutic decisions. In a real-world setting, successful response to atopic dermatitis treatment is measured by sustained ...Jonathan I. Silverberg, Eric L. Simpson, Mark Boguniewicz, Marjolein S. De Bruin-Weller, Peter Foley, Yoko Kataoka, Gaëlle Bégo-Le-Bagousse, Zhen Chen, Brad Shumel, Jingdong Chao, Ana B. Rossi +10 moredoaj +1 more sourceShaping the research agenda of pediatric gastroenterology, hepatology, and nutrition: The proposal from an Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) expert group
JPGN Reports, EarlyView.Abstract
The Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) recognized the need to define research priorities and identify knowledge gaps to guide future investigations in pediatric digestive health. Following international examples, SIGENP aimed to provide a structured framework that aligns scientific innovation with ...Carlo Agostoni, Daniele Alberti, Renata Auricchio, Maria Elisabetta Baldassarre, Osvaldo Borrelli, Matteo Bramuzzo, Teresa Capriati, Carlo Catassi, Sabrina Cenni, Marco Crocco, Salvatore Cucchiara, Luigi Dall'Oglio, Paola De Angelis, Marco Deganello Saccomani, Fabiola Di Dato, Angelo Di Giorgio, Antonella Diamanti, Valeria Dipasquale, Enrico Felici, Ruggiero Francavilla, Valentina Giorgio, Luigi Greco, Raffaele lorio, Flavio Labriola, Paolo Lionetti, Elena Lionetti, Giuseppe Maggiore, Monica Malamisura, Claudia Mandato, Antonio Marseglia, Emanuele Nicastro, Lorenzo Norsa, Salvatore Oliva, Licia Pensabene, Elena Sofia Pieri, Paolo Quitadamo, Giusy Ranucci, Sara Renzo, Claudio Romano, Silvia Salvatore, Luca Scarallo, Maria Immacolata Spagnuolo, Annamaria Staiano, Caterina Strisciuglio, Renato Tambucci, Riccardo Troncone, Pietro Vajro +46 morewiley +1 more source
