Results 61 to 70 of about 15,580 (252)

Biomarkers and patient-related factors associated with clinical outcomes in dupilumab-treated atopic dermatitis

Journal of Allergy and Clinical Immunology: Global
Background: Atopic dermatitis (AD) is a common chronic eczematous skin disease with severe pruritus. Several new therapeutic agents for AD such as dupilumab, an anti–IL-4Rα antibody, have been developed in recent years.
Makiko Kido-Nakahara, MD, Daisuke Onozuka, PhD, Kenji Izuhara, PhD, Hidehisa Saeki, MD, Satoshi Nunomura, PhD, Motoi Takenaka, MD, Mai Matsumoto, MD, Yoko Kataoka, MD, Rai Fujimoto, MD, Sakae Kaneko, MD, Eishin Morita, MD, Akio Tanaka, MD, Michihiro Hide, MD, Tatsuro Okano, MD, Tomomitsu Miyagaki, MD, Natsuko Aoki, MD, Kimiko Nakajima, MD, Susumu Ichiyama, MD, Kyoko Tonomura, MD, Yukinobu Nakagawa, MD, Risa Tamagawa-Mineoka, MD, Koji Masuda, MD, Takuya Takeichi, MD, Masashi Akiyama, MD, Yozo Ishiuji, MD, Michie Katsuta, MD, Yuki Kinoshita, MD, Chiharu Tateishi, MD, Aya Yamamoto, MD, Akimichi Morita, MD, Haruna Matsuda-Hirose, MD, Yutaka Hatano, MD, Hiroshi Kawasaki, MD, Keiji Tanese, MD, Mamitaro Ohtsuki, MD, Koji Kamiya, MD, Yudai Kabata, MD, Riichiro Abe, MD, Hiroshi Mitsui, MD, Tatsuyoshi Kawamura, MD, Gaku Tsuji, MD, Masutaka Furue, MD, Norito Katoh, MD, Takeshi Nakahara, MD   +43 more
doaj   +1 more source

Management of Atopic Dermatitis in Adults in Saudi Arabia: Consensus Recommendations from the Dermatological Expert Group

Clinical, Cosmetic and Investigational Dermatology, 2022
Abdullah Alakeel,1 Afaf Al Sheikh,2,3 Ali A Alraddadi,4– 6 Khalid Mohammed Alattas,7 Maha Aldayel,8 Mohammed Abdulaziz Alajlan,9 Mohammed Al-Haddab,1 Mohammad Almohideb,3,10 Mohamed Fatani,11 Issam R Hamadah,12 Ruaa Alharithy,13,14 Yousef Binamer,15,16 ...
Alakeel A, Al Sheikh A, Alraddadi AA, Alattas KM, Aldayel M, Alajlan MA, Al-Haddab M, Almohideb M, Fatani M, Hamadah IR, Alharithy R, Binamer Y, Papp K, Elaraby A   +13 more
doaj  

Artificial Intelligence in Dermatology: Current Applications and Future Directions

JEADV Clinical Practice, EarlyView.
This scoping review of 56 studies maps AI applications in dermatology. Image‐based classification for skin cancer detection dominates (48%), followed by clinical decision support (21%), teledermatology triage (11%), and predictive analytics (11%). While deep learning algorithms demonstrate diagnostic performance comparable to clinicians in controlled ...
Sofía Pérez‐Lalinde, Francisco Flores   +1 more
wiley   +1 more source

Netherton syndrome: effect on ichthyosis linearis circumflexa with dupilumab

Journal of Dermatological Treatment
Objectives To evaluate the efficacy of Dupilumab in treating Netherton Syndrome (SPINK5-sEDD).Methods We present a girl with SPINK5-sEDD who failed topical therapy.
Ashleigh Ka Ying Chu, James Wesley Ching-Hei Cheng, Ying Yin Lam, Kam Lun Ellis Hon, David Chi Kong Luk   +4 more
doaj   +1 more source

Atopic dermatitis:scoring severity and quality of life assessment

, 2011
To provide a comprehensive assessment of atopic dermatitis severity, it is important to measure a combination of parameters: objective visual skin changes (clinical signs), patient symptoms and quality of life, as all three measures provide different ...
Carolyn R. Charman, M. Susan Lewis-Jones, Lewis-Jones, M. Susan, Charman, Carolyn R.   +3 more
core   +1 more source

When Treatment Meets Natural History: Understanding Early Dermatitis‐Related Adverse Events in Systemic Atopic Dermatitis Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Biologics and Janus kinase (JAK) inhibitors have transformed the management of atopic dermatitis (AD), yet some patients experience early worsening of disease activity during treatment initiation. In clinical trials, these events are typically recorded as treatment‐emergent adverse events (TEAEs), most commonly coded as “atopic dermatitis”. We
Diego Ruiz Dasilva, Alondra Soto‐Gonzalez, Haya Alkiswani, Graham H. Litchman, Harrison Nguyen, Gil Yosipovitch, Firas George Hougeir, Matthew Zirwas, David Cotter, Brad Glick, E. James Song, Christopher G. Bunick, Neal Bhatia, Adam Friedman, Leon Kircik, Mona Shahriari, Peter Lio, James Del Rosso   +17 more
wiley   +1 more source

Case report on Ayurvedic management of Eczema with special reference to Charma Kushta [PDF]

Skin inflammation is referred to as eczema, also referred to as dermatitis. Erythema, vesiculation, and oozing are the symptoms of acute eczema, followed by subacute scaling and crusting and chronic lichenification.
Neethu KS, Ajay Paul
core   +1 more source

Serum Eosinophil Level Correlates With Atopic Dermatitis Severity: A Multicenter Cross‐Sectional Study in Chinese Patients With a Nested Cohort Analysis of Dupilumab Treatment Response

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Personalized treatment strategies for atopic dermatitis (AD) are limited. Although serum total IgE (tIgE) and blood eosinophil levels are proposed biomarkers for AD severity, their clinical utility requires validation. Objectives We aimed to identify biomarkers reflecting AD severity and their association with dupilumab efficacy ...
Zhuying Zhang, Jingwen Xue, Yi Zhao
wiley   +1 more source

Th2/Th17 Inflammation: Pathogenic Drivers and Therapeutic Targets in Darier and Hailey‐Hailey Diseases

JEADV Clinical Practice, EarlyView.
Skin samples of Hailey‐Hailey and Darier diseases were analyzed for inflammatory and barrier markers using indirect immunofluorescence and transcriptomic techniques. A mixed Th2/Th17 inflammatory pattern and altered expression of barrier markers were observed.
Ella Glodjajic, Darko Stojkov, Joanna Boros‐Majewska, Jeremy Di Domizio, Michel Gilliet, Christoph Schlapbach, Timothée Fettrelet, Luca Borradori, Hans‐Uwe Simon, Dagmar Simon, Susanne Radonjic‐Hoesli   +10 more
wiley   +1 more source

Nail Psoriasis in Pediatric Populations

JEADV Clinical Practice, EarlyView.
ABSTRACT Pediatric nail psoriasis is an under‐recognized yet clinically important manifestation of psoriasis with both diagnostic and prognostic implications. Nail involvement in children is associated with greater overall disease severity, poorer treatment outcomes, and is a predictor for the development of psoriatic arthritis.
Aditya K. Gupta, Elizabeth Teasell, Federico Quadrelli, Bianca Maria Piraccini   +3 more
wiley   +1 more source