Results 71 to 80 of about 15,580 (252)

Inducible Laryngeal Obstruction in Hypermobile Patients

The Laryngoscope, EarlyView.
Patients with hypermobile Ehlers‐Danlos syndrome (hEDS) or hypermobility spectrum disorders (HSD) who screened positive for inducible laryngeal obstruction (ILO) reported significantly greater voice, cough, swallowing, gastrointestinal, and mast cell‐related symptoms than those without ILO. Chronic cough, dysphagia, and elevated mast cell symptom score
Stacey M. Menton, DeLisa Fairweather, Frances C. Wilson, Derek J. Zangerle, Emma F. Murphy, Ashley A. Darakjian, Chandler C. Thompson, Shilpa N. Gajarawala, Dacre R. T. Knight, Katelyn A. Bruno, Amy L. Rutt   +10 more
wiley   +1 more source

Synthesis of Microbial‐Derived Octadecanoids

Lipids, EarlyView.
C18‐carbon containing dietary polyunsaturated fatty acids (e.g., linoleic acid, α‐linolenic acid, and γ‐linolenic acid) are metabolized by bacteria in the gut into oxygenated lipid mediators termed octadecanoids. To study the biological function of these compounds, we report here the chemical synthesis of multiple octadecanoids.
Johanna Revol‐Cavalier, Katarína Bankóová, Olivier Salamin, Alessandro Quaranta, Juan Du, Mats Hamberg, Craig E. Wheelock   +6 more
wiley   +1 more source

Severe atopic dermatitis treated with Dupilumab in a CTLA-4-deficient patient: A case report and review of the literature

SAGE Open Medical Case Reports
Atopic dermatitis is a chronic inflammatory skin disease associated with immune dysregulation, particularly overexpression of T helper 2 cytokines. Cytotoxic T lymphocyte-associated antigen 4 deficiency, a primary immune disorder, can exacerbate atopic ...
Ye-Jean Park, Jennifer Grossman, Lynne Robertson   +2 more
doaj   +1 more source

Effectiveness of dupilumab for the treatment of nummular eczema phenotype of atopic dermatitis in adults [PDF]

, 2020
Nummular eczema (NE) is currently considered as one of the clinical phenotypes of atopic dermatitis (AD) of the adult. In this multicentre study, 30 adult patients (age ≥ 18 years) affected with nummular-like AD were treated with dupilumab, a monoclonal ...
De Prezzo S., Hansel K., Tavecchio S., Napolitano M., Fabbrocini G., Nistico S. P., Stingeni L., Patruno C., Foti C., Ferrucci S. M., Napolitano, M., Tavecchio, Simona, Hansel, Katharina, Foti, C., Napolitano, Maddalena, Nisticò, Steven Paul, Fabbrocini, Gabriella, Patruno, Cataldo, Patruno, C., Stingeni, L., De Prezzo, Serena, Stingeni, Luca, Ferrucci, Silvia Mariel, Foti, Caterina   +23 more
core   +1 more source

Sodium Fluoride for Otosclerosis: A Systematic Review and Meta‐analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Sodium fluoride has historically been used to slow progression of hearing loss in patients with otosclerosis, yet the contemporary clinical benefit and optimal daily dose remain unclear. We performed a systematic review and meta‐analysis to evaluate audiologic outcomes associated with fluoride therapy.
Jonathan M. Hughes, Neeti Gandra, Shaun A. Nguyen, Ted A. Meyer, Robert F. Labadie   +4 more
wiley   +1 more source

Pathomechanisms of Atopic Eczema [PDF]

Atopic eczema is a chronic inflammatory skin condition with significant ethnic variability in clinical presentation and treatment response. Research has predominantly focused on Western populations, leaving a critical knowledge gap in understanding AE ...
Baruah, K
core   +3 more sources

Continuous Respiratory Oscillometry in Pediatric Laparoscopic Surgery—The COMET Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Laparoscopic appendectomy is the accepted surgical approach for appendicitis in centers worldwide. Laparoscopic surgery requires the creation of a pneumoperitoneum to facilitate surgical access. Laparoscopic surgery affects the respiratory mechanics of patients under general anesthesia.
Neil Hauser, Emanuela Zannin, Julie Nguyen, Anwen Taplin, Sara Vigevani, David Sommerfield, Raffaele Dellaca, R. Nazim Khan, Aine Sommerfield, Britta S. von Ungern‐Sternberg   +9 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease

Frontiers in Pharmacology, 2018
Cyclic adenosine monophosphate phosphodiesterases (PDEs) regulate pro-inflammatory cytokine production. One isoform, PDE4, is overactive in chronic relapsing inflammatory skin diseases: psoriasis and eczema/atopic dermatitis, and in several cancers. East
Manju Sharma, Corey Levenson, John C. Browning, Emily M. Becker, Ian Clements, Paul Castella, Michael E. Cox, Michael E. Cox   +7 more
doaj   +1 more source

Safety and Efficacy of Deucravacitinib in Japanese Patients With Moderate to Severe Plaque Psoriasis: 5‐Year Analysis of the Phase 3 POETYK PSO‐1, PSO‐4, and Long‐Term Extension Trials

The Journal of Dermatology, EarlyView.
ABSTRACT Deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, is approved in multiple countries for the treatment of moderate to severe plaque psoriasis, as well as generalized pustular and erythrodermic psoriasis in Japan. Deucravacitinib 6 mg once daily was efficacious and well tolerated through 3 years in the pooled population of ...
Yukari Okubo, Akimichi Morita, Yayoi Tada, Shinichi Imafuku, April W. Armstrong, Andrew Blauvelt, John Vaile, Zoran Popmihajlov, Janice Li, Rajesh Sawant, Katsuyoshi Habiro, Katsuki Tsuritani, Mamitaro Ohtsuki   +12 more
wiley   +1 more source