Results 31 to 40 of about 18,084 (203)

A Study Investigating the Synergistic Analgesic Effects of Nefopam and Medetomidine in a Multimodal Pain Management Approach in Mice [PDF]

Journal of Applied Veterinary Sciences
This study explored the type of analgesic interaction between nefopam and medetomidine and evaluated their safety profiles in a mouse model as no previous studies had examined their pharmacological interaction at the antinociceptive level. Adult male and
Hazem Khalil, Gada Faris
doaj   +1 more source

When less is more – efficacy with less toxicity at the ED50 [PDF]

British Journal of Clinical Pharmacology, 2017
The individualization of drug dosage to maximize benefit and minimize risk is always a challenge since desired benefit is often associated with many dose‐related adverse effects. Most disease is subacute and mild to moderate in severity. Doses that give around 50% of the maximum possible drug effect [the effective dose 50 (ED50)] often prove to be ...
Dimmitt, Simon, Stampfer, Hans, Martin, Jennifer H.   +2 more
openaire   +2 more sources

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, EarlyView.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, EarlyView.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source

Avaliação da eficácia do antiveneno botrópico administrado no local da inoculação intramuscular do veneno de Bothrops jararaca: estudo experimental em camundongos Assessment of the efficacy of antivenom injection at the site of the intramuscular inoculation of Bothrops jararaca venom in mice

Revista do Instituto de Medicina Tropical de São Paulo, 1994
Foi determinada, em camundongos de 18 a 20 g, a dose efetiva 50% do antiveneno botrópico, por via intraperitoneal (ip), imediatamente (DE50 Oh) e 30 minutos (DE50 30') após a inoculação de 2 DL50 do veneno de B. jararaca, por via intramuscular (im).
Carla Lilian Agostini Utescher, Silvia Lucia Paro Vieira, Sara Fensterseifer, Liodioneza Adriano Ribeiro, Miguel Tanús Jorge   +4 more
doaj   +1 more source

Moderate sedation with single-dose remimazolam tosilate in elderly male patients undergoing transurethral resection of the prostate with spinal anesthesia: a prospective, single-arm, single-centre clinical trial

BMC Anesthesiology, 2022
Background Remimazolam tosilate (RT) is a newly listed benzodiazepine for sedation and anesthesia featuring quick onset of effects, short maintenance and recovery times, which is currently under research.
Tang-yuan-meng Zhao, Di Chen, Hu Sun, Zhi-xin Xu, Song Lyu, Tao Wang, Li-li Liu   +6 more
doaj   +1 more source

Selenium‐Containing Tea‐Derived Peptides Activate Alcohol Dehydrogenase and Ameliorate Alcohol‐Induced Liver Injury by Modulating Oxidative Stress Homeostasis

Food Frontiers, EarlyView.
The graphical abstract summarizes the experimental workflow: (1) Preparation of selenium‐containing tea‐derived peptides (TSE‐PP) guided by ADH activation; (2) Purification and LC‐MS/MS identification of selenium‐modified peptides; (3) Molecular docking to reveal peptide‐ADH interactions; (4) Evaluation of hangover‐alleviating and hepatoprotective ...
Lixia Zan, Wenyi Zhang, Ning Gao, Jing Fu, Wengang Jin, Xiaoning Zhao, Xinsheng Li, Tianli Yue   +7 more
wiley   +1 more source

Minimum effective dose of intrathecal hyperbaric bupivacaine for cesarean section with and without prophylactic norepinephrine infusion: Randomized triple-blinded trial

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Vasopressor usage can affect the rostral spread of intrathecal drug and, hence, its requirement during cesarean delivery. Although a decreased spread is evidenced with phenylephrine, there is no data for norepinephrine usage.
Asha Tyagi, Monika Mathur, Rashmi Salhotra, Rajesh S. Rautela   +3 more
doaj   +1 more source

Steaming soil is effective in eliminating invasive alien plants (IAPs) – part I: effect of exposure method

Pest Management Science, Volume 81, Issue 4, Page 2032-2039, April 2025.
As regulations on chemical pesticides become more stringent, it is likely that there will be interest in water steam as an alternative approach for soil disinfestation. This study investigated the feasibility of utilizing a soil steaming device for thermal control of selected invasive alien plants and showed a promising mortality rate for their ...
Zahra Bitarafan, Wiktoria Kaczmarek‐Derda, Therese With Berge, Carl Emil Øyri, Inger Sundheim Fløistad   +4 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source