Results 41 to 50 of about 18,317 (173)

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Moderate sedation with single-dose remimazolam tosilate in elderly male patients undergoing transurethral resection of the prostate with spinal anesthesia: a prospective, single-arm, single-centre clinical trial

BMC Anesthesiology, 2022
Background Remimazolam tosilate (RT) is a newly listed benzodiazepine for sedation and anesthesia featuring quick onset of effects, short maintenance and recovery times, which is currently under research.
Tang-yuan-meng Zhao, Di Chen, Hu Sun, Zhi-xin Xu, Song Lyu, Tao Wang, Li-li Liu   +6 more
doaj   +1 more source

Applying the reinforcer pathology model to alcohol use and suicide risk: An initial test

Journal of the Experimental Analysis of Behavior, Volume 126, Issue 2, September 2026.
Abstract Alcohol use and suicide risk have a well‐established relation. In the United States, up to a third of suicide decedents have alcohol in their blood at the time of death and half of those have a blood alcohol level above the legal driving limit (i.e., 0.08% blood alcohol content). Despite the established relation, the mechanisms linking alcohol
Mark J. Rzeszutek, James G. Murphy, Julie Cerel, Christopher T. Franck, Mikhail N. Koffarnus   +4 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

The optimum sevoflurane concentration for supraglottic airway device Blockbuster™ insertion with spontaneous breathing in obese patients: a prospective observational study

BMC Anesthesiology, 2017
Background Airway management of the obese patient presenting for surgery is more likely to be a challenging problem. Supraglottic airway device has been adopted as a bridge to connect ventilation and tracheal intubation in obese patients who would be ...
Haixia Wang, Xue Gao, Wei Wei, Huihui Miao, Hua Meng, Ming Tian   +5 more
doaj   +1 more source

Goniothalamin as a Styryl‐Lactone Toxicophore in Cancer Models: Electrophile‐Driven DNA Damage, Reactive Oxygen Species–Endoplasmic Reticulum Stress Signaling and Detoxification‐Relevant Safety Considerations

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Goniothalamin (GTN) exerts anticancer effects by promoting reactive oxygen species (ROS) generation, glutathione (GSH) depletion, DNA damage, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction. These interconnected events trigger apoptosis, necroptosis, anoikis, and autophagy, while modulating mitogen‐activated protein kinase (MAPK ...
Nataša Joković, Strahinja Pešić, Marija Novaković, Anđela Dubroja Krstić, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Decoding Akkermansia muciniphila Effector Biology: From Microbial Molecules to Host Outcomes

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
Schematic overview of the proposed gut–brain axis mechanisms linking Akkermansia muciniphila to host outcomes. A. muciniphila‐derived signals, including SCFAs and P9/GLP‐1‐related endocrine pathways, may influence epithelial barrier integrity, inflammatory responses, systemic immune signaling, and neural communication through the enteric nervous system,
Amir Arsalan Ghahari, Ainur Sadykova, Salim Davlatov, Mukaddas Xusanova, Gulrukh Indiaminova, Furkat Sobirov, Mirzamakhmud Shadmanov, Umidjon Maxamatov, Patkhiddin Nishonov, Seyed Davar Siadat   +9 more
wiley   +1 more source

Targeting the Carotid Body Function With Big‐K+‐Channel Blocker ENA‐001 in Opioid‐Induced Respiratory Depression: A Scoping Review

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Opioids, most intravenous anesthetics and various illicit substances can cause fatal respiratory depression by depressing central respiratory networks. ENA‐001, a ventilatory modulator targeting the carotid bodies, has emerged as a potential countermeasure without impairing analgesia or hypnosis.
Jimmy J. Arevalo, Monique van Velzen, Simone C. Jansen, Maarten van Lemmen, Elise Sarton, Albert Dahan, Erik Olofsen, Joseph F. Cotten, Marieke Niesters, Rutger M. van der Schrier   +9 more
wiley   +1 more source

Multi‐Omics‐Guided Design and Safety Engineering of Nucleic Acid Therapeutics: From Molecular Perturbation to Predictive Toxicology and Precision Translation

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Multi‐omics (proteomics, metabolomics, and single‐cell/spatial transcriptomics) provides a systems framework to distinguish on‐target efficacy from off‐target and toxicity signatures of chemically modified nucleic acid therapeutics, enabling omics‐guided structure–activity and safety optimisation from discovery to clinical translation. ABSTRACT Nucleic
Gurjit Kaur Bhatti, Anushka Verma, Komal Devi, Naina Khullar, Inderpal Singh Sidhu, Umesh Chand Singh Yadav, Jasvinder Singh Bhatti   +6 more
wiley   +1 more source

Quantitative and Clinical Pharmacology Perspectives on Next‐Generation Malaria Prevention Using Vaccines and Long‐Acting Monoclonal Antibodies

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Malaria remains a significant global health burden, particularly among pediatric populations in endemic regions. Recent advances in preventive interventions highlight the complementary roles of vaccines and long‐acting monoclonal antibodies (mAbs) in reducing infection risk.
Sabiha R. Mim, Leonardo C. Xavier, Francine J. Azeredo, Sihem Ait‐Oudhia   +3 more
wiley   +1 more source